[{"slug":"semaglutide","name":"Semaglutide","fullName":"Semaglutide (GLP-1 receptor agonist)","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Semaglutide has a huge record of human trials.","band":"strong","bandWhy":"12 completed trials, 42,363 people given it","nulls":2,"nullsWorthShowing":false,"reports":10,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2026},{"slug":"retatrutide","name":"Retatrutide","fullName":"Retatrutide (triple GLP-1/GIP/glucagon agonist)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"As of September 2026, almost everything published on retatrutide comes from mid-stage trials.","band":"strong","bandWhy":"5 completed trials, 1,345 people given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"tirzepatide","name":"Tirzepatide","fullName":"Tirzepatide (dual GIP/GLP-1 receptor agonist)","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Tirzepatide has been tested in tens of thousands of people.","band":"strong","bandWhy":"9 completed trials, 22,802 people given it","nulls":0,"nullsWorthShowing":false,"reports":11,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2025},{"slug":"cotadutide","name":"Cotadutide","fullName":"Cotadutide (MEDI0382), GLP-1 and glucagon receptor dual agonist","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A large mid-stage record and no final-stage study.","band":"strong","bandWhy":"6 completed trials, 1,221 people given it","nulls":1,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2024},{"slug":"insulin","name":"Insulin","fullName":"Insulin (human regular insulin and the analogues)","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"The deepest record of any peptide on this site.","band":"strong","bandWhy":"5 completed trials, 29,691 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2023},{"slug":"melanotan-2","name":"Melanotan II","fullName":"Melanotan II (melanocortin receptor agonist)","category":"Melanocortin","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Melanotan II has almost no controlled human data for what people buy it for.","band":"strong","bandWhy":"5 completed trials, 1,310 people given it","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2020},{"slug":"tesamorelin","name":"Tesamorelin","fullName":"Tesamorelin (stabilized GHRH analogue)","category":"Growth Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Tesamorelin is one of the few drugs that boost growth hormone to go all the way through the large trials needed for approval.","band":"strong","bandWhy":"8 completed trials, 1,729 people given it","nulls":3,"nullsWorthShowing":true,"reports":10,"reportedSideEffects":7,"isPeptide":true,"newestStudy":2025},{"slug":"thymosin-beta-4","name":"Thymosin Beta-4","fullName":"Thymosin Beta-4 (TB4)","category":"Healing & Recovery","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Thymosin beta 4's real record in people is eye drops, and they mostly failed.","band":"strong","bandWhy":"5 completed trials, 1,382 people given it","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2026},{"slug":"rapastinel","name":"Rapastinel","fullName":"Rapastinel (GLYX-13), intravenous NMDA receptor glycine site partial agonist tetrapeptide","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A lot of people.","band":"strong","bandWhy":"5 completed trials, 2,614 people given it","nulls":1,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2022},{"slug":"survodutide","name":"Survodutide","fullName":"Survodutide (GLP-1 / glucagon dual agonist)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Survodutide has a large, standard drug company record in people.","band":"strong","bandWhy":"5 completed trials, 2,034 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"taspoglutide","name":"Taspoglutide","fullName":"Taspoglutide (R1583, BIM-51077), once-weekly GLP-1 receptor agonist, development halted in phase 3","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A large final-stage programme.","band":"strong","bandWhy":"3 completed trials, 2,181 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2013},{"slug":"bnp-nesiritide","name":"BNP and nesiritide","fullName":"B-type natriuretic peptide (BNP) and nesiritide (Natrecor), the recombinant drug","category":"Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"The record is unusually complete, and mostly negative.","band":"strong","bandWhy":"3 completed trials, 7,149 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2018},{"slug":"cagrisema","name":"CagriSema","fullName":"CagriSema (cagrilintide + semaglutide)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"CagriSema has large final-stage trial data for a drug that is not yet approved.","band":"strong","bandWhy":"3 completed trials, 4,954 people given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"liraglutide","name":"Liraglutide","fullName":"Liraglutide (GLP-1 receptor agonist)","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Liraglutide has a deep record of human trials: a heart trial in 9,340 patients, four weight-loss trials, a three-year trial on preventing diabetes an…","band":"strong","bandWhy":"6 completed trials, 16,760 people given it","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2022},{"slug":"cagrilintide","name":"Cagrilintide","fullName":"Cagrilintide (long-acting amylin receptor agonist)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nearly everyone who has taken cagrilintide took it as half of a combination with semaglutide.","band":"strong","bandWhy":"5 completed trials, 5,752 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"mazdutide","name":"Mazdutide","fullName":"Mazdutide (GLP-1 / glucagon dual agonist)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Mazdutide has finished its large final-stage trials and has two approvals.","band":"strong","bandWhy":"5 completed trials, 2,372 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"tesamorelin-ipamorelin","name":"Tesamorelin / Ipamorelin","fullName":"Tesamorelin and Ipamorelin blend (approved GHRH analogue plus ghrelin mimetic)","category":"Growth Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"One half of this blend has some of the strongest human evidence in this database.","band":"strong","bandWhy":"5 completed trials, 1,507 people given it","nulls":1,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2026},{"slug":"cerebrolysin","name":"Cerebrolysin","fullName":"Cerebrolysin (porcine brain-derived neuropeptides)","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Cerebrolysin has been used in hospitals for decades and has many trials behind it.","band":"strong","bandWhy":"3 completed trials, 1,591 people given it","nulls":1,"nullsWorthShowing":true,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2023},{"slug":"pegcetacoplan","name":"Pegcetacoplan","fullName":"Pegcetacoplan (Empaveli, Syfovre), PEGylated cyclic peptide complement C3 inhibitor","category":"Immune","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Two finished sets of final-stage studies, in two unrelated diseases.","band":"strong","bandWhy":"3 completed trials, 1,258 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2025},{"slug":"pt-141","name":"PT-141","fullName":"Bremelanotide (melanocortin receptor agonist)","category":"Melanocortin","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Bremelanotide (PT-141) has a well-recorded safety record: 3,500 people across 43 finished studies.","band":"strong","bandWhy":"4 completed trials, 2,355 people given it","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2024},{"slug":"retatrutide-cagrilintide","name":"Retatrutide with cagrilintide","fullName":"Retatrutide with cagrilintide (grey-market blend)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Each drug has early-stage data in people on its own.","band":"strong","bandWhy":"4 completed trials, 4,557 people given it","nulls":1,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2025},{"slug":"semaglutide-cagrilintide","name":"Semaglutide with cagrilintide","fullName":"Grey-market semaglutide with cagrilintide blend","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"This pair has its own large final-stage study in people.","band":"strong","bandWhy":"4 completed trials, 4,219 people given it","nulls":1,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2025},{"slug":"triptorelin","name":"Triptorelin","fullName":"Triptorelin (Trelstar, Triptodur, Decapeptyl), GnRH receptor agonist","category":"Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Big and steady on hormone suppression.","band":"strong","bandWhy":"4 completed trials, 1,388 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2020},{"slug":"enlicitide","name":"Enlicitide","fullName":"Enlicitide decanoate (oral macrocyclic peptide PCSK9 inhibitor)","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Large and recent.","band":"strong","bandWhy":"3 completed trials, 2,909 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"relaxin-2","name":"Relaxin-2","fullName":"Relaxin-2, and serelaxin as its recombinant form","category":"Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two large final-stage trials in sudden heart failure, with almost 7,700 people between them.","band":"strong","bandWhy":"2 completed trials, 7,706 people given it","nulls":2,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2025},{"slug":"thymosin-alpha-1","name":"Thymosin Alpha-1","fullName":"Thymosin Alpha-1 (Thymalfasin)","category":"Immune","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Thymosin alpha-1 has been given to thousands of people in controlled trials.","band":"strong","bandWhy":"2 completed trials, 1,204 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"thymosin-alpha-1-kpv-ll-37","name":"Thymosin alpha-1 with KPV and LL-37","fullName":"Thymosin alpha-1 with KPV and LL-37 (immune and gut blend)","category":"Immune","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One ingredient has a large final-stage study that found no benefit.","band":"strong","bandWhy":"3 completed trials, 1,140 people given it","nulls":1,"nullsWorthShowing":true,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2025},{"slug":"vk2735","name":"VK2735","fullName":"VK2735 (dual GLP-1 / GIP agonist)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An experimental weekly shot from Viking Therapeutics that works on two appetite signals, GLP-1 and GIP.","band":"strong","bandWhy":"3 completed trials, 4,650 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"exenatide","name":"Exenatide","fullName":"Exenatide (GLP-1 receptor agonist)","category":"Metabolic","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"The first approved drug in the GLP-1 family.","band":"strong","bandWhy":"2 completed trials, 15,088 people given it","nulls":1,"nullsWorthShowing":true,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2017},{"slug":"lixisenatide","name":"Lixisenatide","fullName":"Lixisenatide (GLP-1 receptor agonist)","category":"Metabolic","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"An FDA-approved daily shot for type 2 diabetes in the GLP-1 family.","band":"strong","bandWhy":"2 completed trials, 6,068 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2015},{"slug":"plecanatide","name":"Plecanatide","fullName":"Plecanatide (Trulance), uroguanylin analogue and guanylate cyclase-C agonist","category":"Healing & Recovery","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A finished set of final-stage studies in long-term constipation and in IBS with constipation.","band":"strong","bandWhy":"2 completed trials, 1,337 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2023},{"slug":"thymalin-epitalon","name":"Thymalin with epitalon","fullName":"Thymalin with epitalon or epithalamin (Khavinson bioregulator protocol)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is a real study of the pair with amazing numbers.","band":"strong","bandWhy":"2 completed trials, 1,106 people given it","nulls":1,"nullsWorthShowing":true,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2025},{"slug":"argireline","name":"Argireline","fullName":"Acetyl Hexapeptide-8 (Argireline)","category":"Cosmetic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Argireline has been tested in six small studies in people.","band":"moderate","bandWhy":"4 completed trials, 155 people given it","nulls":1,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"hexarelin","name":"Hexarelin","fullName":"Hexarelin (growth hormone secretagogue)","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Hexarelin was given to people in a string of small hormone studies in the 1990s.","band":"moderate","bandWhy":"6 completed trials, 105 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2002},{"slug":"rusfertide","name":"Rusfertide","fullName":"Rusfertide (PTG-300), synthetic cyclic peptide hepcidin mimetic","category":"Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"One large final-stage study of 293 people against a dummy injection (VERIFY, 32 weeks, so far reported only on the FDA label).","band":"moderate","bandWhy":"5 completed trials, 166 people given it","nulls":1,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"anp","name":"ANP","fullName":"Atrial natriuretic peptide (ANP), and carperitide as the recombinant form","category":"Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is a lot of human dosing experience.","band":"moderate","bandWhy":"4 completed trials, 188 people given it","nulls":2,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2025},{"slug":"brimapitide","name":"Brimapitide","fullName":"Brimapitide (XG-102, AM-111, D-JNKI-1), cell penetrating JNK inhibitor peptide","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Roughly 1,200 people have had brimapitide across seven studies in hearing loss, eye swelling and healthy men.","band":"moderate","bandWhy":"4 completed trials, 510 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2019},{"slug":"epitalon","name":"Epitalon","fullName":"Epitalon (Epithalon, pineal tetrapeptide)","category":"Anti-aging","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is human data on Epitalon and its parent pineal extract, Epithalamin, going back decades.","band":"moderate","bandWhy":"5 completed trials, 266 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"glepaglutide","name":"Glepaglutide","fullName":"Glepaglutide (ZP1848), long-acting GLP-2 receptor agonist","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One large study of 106 people over 24 weeks against a dummy injection.","band":"moderate","bandWhy":"3 completed trials, 230 people given it","nulls":2,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"io102-io103","name":"IO102-IO103","fullName":"IO102-IO103, two peptide immune modulatory cancer vaccine targeting IDO1 and PD-L1 expressing cells","category":"Immune","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A lot for a test vaccine.","band":"moderate","bandWhy":"3 completed trials, 470 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2026},{"slug":"melanotan-1","name":"Melanotan I","fullName":"Afamelanotide (Melanotan I)","category":"Melanocortin","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Afamelanotide, the approved form of Melanotan I, has the strongest record in people of any compound in this group.","band":"moderate","bandWhy":"2 completed trials, 170 people given it","nulls":1,"nullsWorthShowing":true,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2025},{"slug":"angiotensin-ii","name":"Angiotensin II","fullName":"Angiotensin II (Giapreza, LJPC-501)","category":"Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"One large study in 344 very sick adults, compared with a dummy drip.","band":"moderate","bandWhy":"1 completed trial, 344 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2023},{"slug":"bofanglutide","name":"Bofanglutide","fullName":"Bofanglutide, long-acting GLP-1 receptor agonist (development code GZR18)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two mid-stage studies are published.","band":"moderate","bandWhy":"5 completed trials, 750 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2026},{"slug":"elamipretide","name":"Elamipretide","fullName":"Elamipretide (SS-31, mitochondrial-targeted peptide)","category":"Anti-aging","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Elamipretide has a large, well-reported record in people, and most of it is negative.","band":"moderate","bandWhy":"5 completed trials, 487 people given it","nulls":3,"nullsWorthShowing":true,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2025},{"slug":"icatibant","name":"Icatibant","fullName":"Icatibant (Firazyr), bradykinin B2 receptor antagonist","category":"Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Strong for the approved use, and clearly mixed outside it.","band":"moderate","bandWhy":"5 completed trials, 306 people given it","nulls":2,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2023},{"slug":"kisspeptin-54","name":"Kisspeptin-54","fullName":"Kisspeptin-54, the 54 residue KISS1 gene product","category":"Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Plenty of controlled human studies, almost all about fertility hormones.","band":"moderate","bandWhy":"5 completed trials, 122 people given it","nulls":1,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2025},{"slug":"melittin","name":"Melittin","fullName":"Melittin, the principal pore forming peptide of honey bee (Apis mellifera) venom","category":"Healing & Recovery","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"For melittin on its own: one study, where it was injected into forearms to cause pain.","band":"moderate","bandWhy":"5 completed trials, 658 people given it","nulls":1,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2020},{"slug":"nemifitide","name":"Nemifitide","fullName":"Nemifitide (INN 00835), subcutaneous pentapeptide antidepressant, development ceased","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"188 patients took part in three small studies that compared it with a dummy shot.","band":"moderate","bandWhy":"5 completed trials, 177 people given it","nulls":1,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2008},{"slug":"carbetocin-intranasal","name":"Carbetocin (intranasal)","fullName":"Intranasal carbetocin, a long-acting oxytocin receptor agonist","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two large final-stage studies against a dummy spray, 305 people between them, plus an extension study of 168 that was stopped.","band":"moderate","bandWhy":"3 completed trials, 343 people given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"cjc-1295-ipamorelin-ghrp-2","name":"CJC-1295 with ipamorelin and GHRP-2","fullName":"CJC-1295 (with DAC) with ipamorelin and GHRP-2","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No study of the three together.","band":"moderate","bandWhy":"2 completed trials, 117 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2014},{"slug":"ghrp-2","name":"GHRP-2","fullName":"Pralmorelin (Growth Hormone Releasing Peptide 2)","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"GHRP-2 is approved in Japan as a one-dose test for growth hormone problems, and that is where the solid human data sit.","band":"moderate","bandWhy":"3 completed trials, 102 people given it","nulls":2,"nullsWorthShowing":true,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2007},{"slug":"peg-loxenatide","name":"PEG-loxenatide","fullName":"Polyethylene glycol loxenatide, PEGylated exendin-4 analogue","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two large studies at many hospitals, with a dummy-shot group and nobody knowing who got what.","band":"moderate","bandWhy":"4 completed trials, 590 people given it","nulls":2,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"pramlintide","name":"Pramlintide","fullName":"Pramlintide (amylin analogue)","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"The only amylin drug ever approved for diabetes.","band":"moderate","bandWhy":"3 completed trials, 684 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2015},{"slug":"risuteganib","name":"Risuteganib","fullName":"Risuteganib (ALG-1001, Luminate), intravitreal integrin regulating peptide","category":"Healing & Recovery","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"About 435 people have had risuteganib injected into the eye across six early and mid-stage studies between 2012 and 2019.","band":"moderate","bandWhy":"2 completed trials, 263 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2022},{"slug":"semax","name":"Semax","fullName":"Semax (synthetic ACTH 4-10 analogue)","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Semax has real studies in people, and almost all of them are Russian.","band":"moderate","bandWhy":"4 completed trials, 354 people given it","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"thymalin","name":"Thymalin","fullName":"Thymalin (thymic peptide bioregulator)","category":"Immune","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Thymalin has more human use behind it than almost any compound on this site that no Western regulator has ever reviewed.","band":"moderate","bandWhy":"4 completed trials, 308 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"visepegenatide","name":"Visepegenatide","fullName":"Visepegenatide, PEGylated exenatide for once-weekly injection (development code PB-119)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One published large final-stage study with a dummy-shot group, in 273 Chinese adults on no diabetes drug yet.","band":"moderate","bandWhy":"4 completed trials, 572 people given it","nulls":1,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2024},{"slug":"amycretin","name":"Amycretin","fullName":"Amycretin (unimolecular GLP-1 / amylin agonist)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Novo Nordisk's single drug that works on both GLP-1 and amylin, a fullness hormone.","band":"moderate","bandWhy":"1 completed trial, 125 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"beinaglutide","name":"Beinaglutide","fullName":"Beinaglutide, recombinant human GLP-1 (7-36) amide","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A 427-person final-stage study for weight loss where nobody knew who got the drug.","band":"moderate","bandWhy":"2 completed trials, 443 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2024},{"slug":"degarelix","name":"Degarelix","fullName":"Degarelix (Firmagon), GnRH receptor antagonist","category":"Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"One large study showing it pushes testosterone down as well as leuprolide, faster and with no flare.","band":"moderate","bandWhy":"2 completed trials, 610 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2021},{"slug":"ecnoglutide","name":"Ecnoglutide","fullName":"Ecnoglutide (long-acting GLP-1 agonist)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A long-acting GLP-1 shot, approved in China in 2026 for type 2 diabetes and weight loss.","band":"moderate","bandWhy":"3 completed trials, 664 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"efinopegdutide","name":"Efinopegdutide","fullName":"Efinopegdutide (MK-6024), GLP-1 and glucagon receptor dual agonist","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One head-to-head study against another drug, which is a stronger design than most drugs have at this stage.","band":"moderate","bandWhy":"1 completed trial, 145 people given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"gonadorelin","name":"Gonadorelin","fullName":"Gonadorelin (synthetic GnRH)","category":"Hormone","tier":"many","usLegal":"rx","usLabel":"Prescription","humanLine":"Gonadorelin has a solid record in people for one job.","band":"moderate","bandWhy":"3 completed trials, 110 people given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"ipamorelin","name":"Ipamorelin","fullName":"Ipamorelin Acetate","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Ipamorelin's only published human trial of a benefit missed its goal.","band":"moderate","bandWhy":"2 completed trials, 157 people given it","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2014},{"slug":"larazotide","name":"Larazotide","fullName":"Larazotide Acetate (AT-1001)","category":"Healing & Recovery","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A gut barrier peptide for celiac disease that is still being tested.","band":"moderate","bandWhy":"2 completed trials, 526 people given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2022},{"slug":"ll-37","name":"LL-37","fullName":"LL-37 (human cathelicidin antimicrobial peptide)","category":"Immune","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"LL-37 has been given to people in two trials for leg ulcers caused by poor vein circulation.","band":"moderate","bandWhy":"2 completed trials, 182 people given it","nulls":1,"nullsWorthShowing":true,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2021},{"slug":"nnc0165-1875","name":"NNC0165-1875","fullName":"NNC0165-1875 (PYY1875), long-acting PYY(3-36) analogue","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A first study in people and a mid-stage trial are done, and both were published together with the rat work.","band":"moderate","bandWhy":"3 completed trials, 120 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2025},{"slug":"nnc0480-0389","name":"NNC0480-0389","fullName":"NNC0480-0389, long-acting GIP receptor agonist","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A registered early and mid-stage programme with no published results.","band":"moderate","bandWhy":"1 completed trial, 500 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2026},{"slug":"selank","name":"Selank","fullName":"Selank (synthetic tuftsin analogue)","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Selank has been tested in 192 people across three published studies.","band":"moderate","bandWhy":"3 completed trials, 192 people given it","nulls":1,"nullsWorthShowing":true,"reports":8,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2021},{"slug":"sermorelin","name":"Sermorelin","fullName":"Sermorelin (GHRH 1-29 analogue)","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Sermorelin was an approved drug and has real trial data.","band":"moderate","bandWhy":"3 completed trials, 139 people given it","nulls":1,"nullsWorthShowing":true,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2013},{"slug":"sermorelin-ipamorelin","name":"Sermorelin with ipamorelin","fullName":"Sermorelin acetate with ipamorelin","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The pair has no study.","band":"moderate","bandWhy":"1 completed trial, 117 people given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2018},{"slug":"thymopentin","name":"Thymopentin","fullName":"Thymopentin (TP-5, thymopoietin fragment)","category":"Immune","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A five-part piece of a thymus hormone, used in some countries to tune the immune system.","band":"moderate","bandWhy":"3 completed trials, 306 people given it","nulls":1,"nullsWorthShowing":true,"reports":3,"reportedSideEffects":1,"isPeptide":true,"newestStudy":1994},{"slug":"abaloparatide","name":"Abaloparatide","fullName":"Abaloparatide (PTHrP analogue)","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"An FDA-approved bone-building shot for women past menopause with bone thinning.","band":"moderate","bandWhy":"1 completed trial, 2,463 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2018},{"slug":"amylin","name":"Amylin","fullName":"Amylin (islet amyloid polypeptide)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Deep for the copies, almost nothing for the hormone itself.","band":"moderate","bandWhy":"2 completed trials, 651 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2025},{"slug":"cetrorelix","name":"Cetrorelix","fullName":"Cetrorelix (GnRH antagonist)","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"An FDA-approved drug used in fertility treatment to stop ovulation from happening too early.","band":"moderate","bandWhy":"1 completed trial, 564 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2016},{"slug":"cgrp","name":"CGRP","fullName":"Calcitonin gene-related peptide, alpha-CGRP","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Lots of evidence, running two ways, and neither way supports taking CGRP.","band":"moderate","bandWhy":"2 completed trials, 968 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2025},{"slug":"davunetide","name":"Davunetide","fullName":"Davunetide (NAP, ADNP-derived peptide)","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A brain-protecting peptide tested in people for brain diseases.","band":"moderate","bandWhy":"1 completed trial, 313 people given it","nulls":1,"nullsWorthShowing":true,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2014},{"slug":"desmopressin","name":"Desmopressin","fullName":"Desmopressin (DDAVP, vasopressin analogue)","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"An FDA-approved copy of vasopressin for diabetes insipidus, bedwetting and some bleeding disorders.","band":"moderate","bandWhy":"1 completed trial, 261 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2025},{"slug":"efocipegtrutide","name":"Efocipegtrutide","fullName":"Efocipegtrutide (HM15211, GLP-1/GIP/glucagon triple agonist)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An experimental shot that works on three signals, GLP-1, GIP and glucagon.","band":"moderate","bandWhy":"2 completed trials, 215 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"glucagon","name":"Glucagon","fullName":"Glucagon (pancreatic hormone)","category":"Metabolic","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"The hormone that raises blood sugar.","band":"moderate","bandWhy":"2 completed trials, 141 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2020},{"slug":"icotrokinra","name":"Icotrokinra","fullName":"Icotrokinra (oral IL-23 receptor targeting peptide)","category":"Immune","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Strong, and unusually complete for a newly approved drug.","band":"moderate","bandWhy":"2 completed trials, 311 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2026},{"slug":"leuprolide","name":"Leuprolide","fullName":"Leuprolide (GnRH agonist)","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A prescription medicine, not a research peptide.","band":"moderate","bandWhy":"2 completed trials, 199 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":1,"isPeptide":true,"newestStudy":1990},{"slug":"matrixyl","name":"Matrixyl","fullName":"Palmitoyl Pentapeptide-4 (Matrixyl)","category":"Cosmetic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There are two studies in people.","band":"moderate","bandWhy":"2 completed trials, 114 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2023},{"slug":"mk-677-ipamorelin","name":"MK-677 with ipamorelin","fullName":"MK-677 (ibutamoren) with ipamorelin, run as one protocol","category":"Growth Hormone","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Each one has been studied alone.","band":"moderate","bandWhy":"2 completed trials, 182 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2018},{"slug":"octreotide","name":"Octreotide","fullName":"Octreotide (somatostatin analogue)","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"An FDA-approved, long-lasting copy of somatostatin, used for acromegaly and hormone-making tumors.","band":"moderate","bandWhy":"2 completed trials, 140 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2005},{"slug":"oxytocin","name":"Oxytocin","fullName":"Oxytocin","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A natural hormone that is FDA-approved to help with childbirth.","band":"moderate","bandWhy":"2 completed trials, 290 people given it","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2021},{"slug":"petrelintide","name":"Petrelintide","fullName":"Petrelintide (long-acting amylin analogue)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A once a week shot from Zealand and Roche that copies amylin, a fullness hormone.","band":"moderate","bandWhy":"1 completed trial, 493 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"semax-selank","name":"Semax / Selank","fullName":"Semax and Selank blend (Russian nootropic peptide pair)","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Each peptide has Russian data in people, at a level this site rates Moderate at best.","band":"moderate","bandWhy":"2 completed trials, 172 people given it","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2020},{"slug":"teriparatide","name":"Teriparatide","fullName":"Teriparatide (parathyroid hormone 1-34)","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"An FDA-approved bone-building shot.","band":"moderate","bandWhy":"1 completed trial, 1,637 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2018},{"slug":"vasopressin","name":"Vasopressin","fullName":"Vasopressin (antidiuretic hormone, AVP)","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"The natural hormone that makes you hold on to water.","band":"moderate","bandWhy":"1 completed trial, 778 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2016},{"slug":"ziconotide","name":"Ziconotide","fullName":"Ziconotide (Prialt), synthetic omega-conotoxin MVIIA","category":"Nootropic & CNS","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Two studies with a dummy group back the approval.","band":"moderate","bandWhy":"2 completed trials, 111 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2017},{"slug":"ct-868","name":"CT-868","fullName":"CT-868, once-daily biased dual GLP-1 and GIP receptor agonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One published mid-stage study in 103 adults with type 2 diabetes who were also overweight or obese.","band":"moderate","bandWhy":"1 completed trial, 103 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"kisspeptin-10","name":"Kisspeptin-10","fullName":"Kisspeptin-10","category":"Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Kisspeptin-10 has been given to people in body chemistry experiments, not treatment trials.","band":"limited","bandWhy":"4 completed trials, 44 people given it","nulls":1,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2019},{"slug":"mots-c","name":"MOTS-c","fullName":"Mitochondrial ORF of the 12S rRNA type-c","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nobody has published a study giving MOTS-c to people as a drug.","band":"limited","bandWhy":"1 completed trial, 30 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"angiotensin-1-7","name":"Angiotensin-(1-7)","fullName":"Angiotensin-(1-7), the Mas receptor arm of the renin-angiotensin system","category":"Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"People have been given this peptide in at least four published studies, plus a set of small registered studies.","band":"limited","bandWhy":"5 completed trials, 76 people given it","nulls":1,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2024},{"slug":"bpc-157","name":"BPC-157","fullName":"Body Protection Compound 157","category":"Healing & Recovery","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Five published studies have given BPC-157 to people, with fewer than 110 people in all.","band":"limited","bandWhy":"3 completed trials, 31 people given it","nulls":1,"nullsWorthShowing":true,"reports":10,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2026},{"slug":"ghk-cu","name":"GHK-Cu","fullName":"Copper Tripeptide-1 (GHK-Cu)","category":"Healing & Recovery","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"GHK-Cu has been used on more than 20,000 people in published studies.","band":"limited","bandWhy":"2 completed trials, 99 people given it","nulls":2,"nullsWorthShowing":true,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"apelin","name":"Apelin","fullName":"Apelin (endogenous ligand of the APJ receptor; apelin-36, apelin-17 and pyroglutamated apelin-13)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Short drip studies in about 50 people across two published Edinburgh papers.","band":"limited","bandWhy":"3 completed trials, 68 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2024},{"slug":"ara-290","name":"ARA-290","fullName":"Cibinetide (ARA-290)","category":"Healing & Recovery","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"ARA-290, also called cibinetide, has been through a handful of small trials with a dummy treatment, from 9 to 64 people each.","band":"limited","bandWhy":"5 completed trials, 95 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2020},{"slug":"dsip","name":"DSIP","fullName":"Delta Sleep-Inducing Peptide","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"DSIP has been given to people in small studies published between 1981 and 1998, always into a vein.","band":"limited","bandWhy":"6 completed trials, 7 people given it","nulls":1,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"gip","name":"GIP","fullName":"Glucose-dependent insulinotropic polypeptide","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Lots of studies of how the body handles it, and no treatment trials.","band":"limited","bandWhy":"2 completed trials, 10 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2025},{"slug":"ghrp-6","name":"GHRP-6","fullName":"Growth Hormone Releasing Peptide 6","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"GHRP-6 has been given to people in published studies since 1990.","band":"limited","bandWhy":"5 completed trials, 42 people given it","nulls":3,"nullsWorthShowing":true,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"humanin","name":"Humanin","fullName":"Humanin (mitochondrial-derived peptide)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No published study has given humanin, or a drug based on it, to a person.","band":"limited","bandWhy":"1 completed trial, 30 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2024},{"slug":"mecasermin","name":"Mecasermin","fullName":"Mecasermin (Increlex), recombinant human IGF-1","category":"Growth Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"A good deal of evidence in people, in one rare condition.","band":"limited","bandWhy":"1 completed trial, 76 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2023},{"slug":"nad-b-complex","name":"NAD+ / B Complex","fullName":"Injectable NAD+ blended with vitamin B12 and sometimes B6","category":"Longevity","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"There is real human evidence for fixing a B12 shortage.","band":"limited","bandWhy":"5 completed trials, 34 people given it","nulls":2,"nullsWorthShowing":true,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2020},{"slug":"sermorelin-ghrp","name":"Sermorelin / GHRP","fullName":"Sermorelin combined with GHRP-2 or GHRP-6 (compounding pharmacy growth hormone blend)","category":"Growth Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"This is the one blend in this group where the pairing has been given to people and measured.","band":"limited","bandWhy":"4 completed trials, 56 people given it","nulls":1,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2005},{"slug":"bradykinin","name":"Bradykinin","fullName":"Bradykinin, the kinin system mediator","category":"Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is real human data on bradykinin, and none of it is about giving it as a treatment.","band":"limited","bandWhy":"2 completed trials, 47 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2024},{"slug":"cjc-1295","name":"CJC-1295","fullName":"CJC-1295 (GHRH analogue)","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"CJC-1295 has real data in people, and all of it is about hormone levels in healthy volunteers.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":1,"nullsWorthShowing":true,"reports":9,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"galanin","name":"Galanin","fullName":"Galanin, the 30 residue human GAL gene product","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A solid set of controlled studies going back to 1986, all about hormones and the heart: growth hormone, insulin, noradrenaline, heart rate, blood pre…","band":"limited","bandWhy":"4 completed trials, 21 people given it","nulls":3,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2020},{"slug":"oxyntomodulin","name":"Oxyntomodulin","fullName":"Oxyntomodulin (glucagon-37)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Small, old and real.","band":"limited","bandWhy":"1 completed trial, 13 people given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2023},{"slug":"sermorelin-ghrp-2-ghrp-6","name":"Sermorelin with GHRP-2 and GHRP-6","fullName":"Sermorelin with GHRP-2 and GHRP-6 (compounded triple blend)","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No study of the triple.","band":"limited","bandWhy":"2 completed trials, 9 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2013},{"slug":"berobenatide","name":"Berobenatide","fullName":"Berobenatide (MET-097i, PF-08653944)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A very long-lasting GLP-1 shot, built to be given once a month.","band":"limited","bandWhy":"3 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"bgm1812","name":"BGM1812","fullName":"BGM1812, dual amylin and calcitonin receptor agonist","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None published.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"cjc-1295-ipamorelin","name":"CJC-1295 / Ipamorelin","fullName":"CJC-1295 and Ipamorelin blend (GHRH analogue plus ghrelin mimetic)","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is human evidence for CJC-1295 alone, and for ipamorelin alone.","band":"limited","bandWhy":"2 completed trials, 20 people given it","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2026},{"slug":"cjc-1295-ghrp-2","name":"CJC-1295 with GHRP-2","fullName":"CJC-1295 (no DAC) with GHRP-2","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"People have been given these two kinds of drugs together, and the pair worked on growth hormone.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2018},{"slug":"cjc-1295-ghrp-6","name":"CJC-1295 with GHRP-6","fullName":"CJC-1295 (no DAC) with GHRP-6","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nobody has studied the pair.","band":"limited","bandWhy":"2 completed trials, 9 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2018},{"slug":"dermorphin","name":"Dermorphin","fullName":"Dermorphin, frog skin heptapeptide mu-opioid agonist (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2)","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"22 people, all in Italian hormone studies in 1983 and 1985 that used dermorphin as a tool to study the pituitary gland.","band":"limited","bandWhy":"1 completed trial, 11 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2020},{"slug":"dsip-selank-epitalon","name":"DSIP with selank and epitalon","fullName":"Delta sleep-inducing peptide with selank and epitalon (sleep blend)","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The sleep evidence is two studies from the 1980s, for one ingredient.","band":"limited","bandWhy":"1 completed trial, 62 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2025},{"slug":"eloralintide","name":"Eloralintide","fullName":"Eloralintide (LY3841136)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Lilly's weekly shot that copies amylin, a fullness hormone.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"enicepatide","name":"Enicepatide","fullName":"Enicepatide (CT-388, RO7795068)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Roche's weekly shot that works on GLP-1 and GIP.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"glow","name":"GLOW blend","fullName":"GLOW (GHK-Cu + BPC-157 + TB-500)","category":"Cosmetic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for the mix.","band":"limited","bandWhy":"2 completed trials, 22 people given it","nulls":1,"nullsWorthShowing":true,"reports":9,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2026},{"slug":"melanotan-2-pt-141","name":"Melanotan II with PT-141","fullName":"Melanotan II with bremelanotide (PT-141)","category":"Melanocortin","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Each drug has studies in people.","band":"limited","bandWhy":"3 completed trials, 10 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2019},{"slug":"neuropeptide-y","name":"Neuropeptide Y","fullName":"Neuropeptide Y (NPY)","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One large year-long study of a pill that blocks an NPY receptor, which failed.","band":"limited","bandWhy":"3 completed trials, 20 people given it","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2018},{"slug":"pemvidutide","name":"Pemvidutide","fullName":"Pemvidutide (GLP-1 / glucagon dual agonist)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An experimental weekly shot from Altimmune that works on GLP-1 and glucagon.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"pyy","name":"Peptide YY","fullName":"Peptide YY (PYY, including the circulating fragment PYY3-36)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A handful of small studies gave PYY by drip and measured eating over a few hours.","band":"limited","bandWhy":"3 completed trials, 12 people given it","nulls":1,"nullsWorthShowing":true,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2017},{"slug":"pinealon","name":"Pinealon","fullName":"Pinealon (Glu-Asp-Arg peptide bioregulator)","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Pinealon's human record is three small Russian studies.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2020},{"slug":"pt-141-oxytocin","name":"PT-141 with oxytocin","fullName":"Bremelanotide (PT-141) with oxytocin acetate","category":"Melanocortin","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One half is an approved drug with two large studies.","band":"limited","bandWhy":"3 completed trials, 10 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2019},{"slug":"ribupatide","name":"Ribupatide","fullName":"Ribupatide (HRS9531, KAI-9531)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A weekly shot that works on GLP-1 and GIP, like tirzepatide.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"teduglutide","name":"Teduglutide","fullName":"Teduglutide (GLP-2 analogue)","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"An FDA-approved shot that helps the gut grow in short bowel syndrome, so people need less feeding through a vein.","band":"limited","bandWhy":"2 completed trials, 83 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2016},{"slug":"ahk-cu-ghk-cu","name":"AHK-Cu with GHK-Cu","fullName":"AHK-Cu with GHK-Cu (topical copper peptide pair)","category":"Cosmetic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One ingredient has one small skin study that failed.","band":"limited","bandWhy":"1 completed trial, 13 people given it","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2026},{"slug":"apraglutide","name":"Apraglutide","fullName":"Apraglutide (FE 203799), once-weekly GLP-2 analogue","category":"Healing & Recovery","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two published studies in short bowel syndrome with gut failure.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2024},{"slug":"at673","name":"AT673","fullName":"AT673, GIP receptor antagonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No published human data for this drug.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"azd6234","name":"AZD6234","fullName":"AZD6234, long-acting amylin analog","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"AstraZeneca's weekly amylin shot.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"bgm0504","name":"BGM0504","fullName":"BGM0504, dual GLP-1 and GIP receptor agonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An early safety study in 40 volunteers and a mid-stage study in 64 people with type 2 diabetes, both published.","band":"limited","bandWhy":"1 completed trial, 64 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"dapiglutide","name":"Dapiglutide","fullName":"Dapiglutide, GLP-1 and GLP-2 receptor dual agonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One 12-week first test in 54 people, against a dummy injection, and it missed its main goal.","band":"limited","bandWhy":"1 completed trial, 54 people given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"ghk-cu-zinc-thymulin","name":"GHK-Cu with zinc thymulin","fullName":"Topical GHK-Cu with zinc thymulin scalp serum","category":"Cosmetic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No proper study of either ingredient for hair growth in people, and none of the mix.","band":"limited","bandWhy":"1 completed trial, 13 people given it","nulls":1,"nullsWorthShowing":true,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"ghrelin","name":"Ghrelin","fullName":"Ghrelin (endogenous growth hormone secretagogue)","category":"Growth Hormone","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The body's own hunger hormone.","band":"limited","bandWhy":"2 completed trials, 27 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2004},{"slug":"glow-capsules","name":"GLOW capsules","fullName":"GLOW oral capsules (GHK-Cu + BPC-157 + TB-500 with hyaluronic acid)","category":"Cosmetic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for the capsule, none for the mix, and none for any of the three peptides taken by mouth.","band":"limited","bandWhy":"1 completed trial, 13 people given it","nulls":1,"nullsWorthShowing":true,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"glp-1","name":"GLP-1","fullName":"Glucagon-Like Peptide-1 (native incretin hormone)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The natural gut hormone behind the whole GLP-1 drug family.","band":"limited","bandWhy":"2 completed trials, 8 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2023},{"slug":"klow","name":"KLOW blend","fullName":"KLOW (GHK-Cu + KPV + BPC-157 + TB-500)","category":"Healing & Recovery","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for the mix, and no registered study of it.","band":"limited","bandWhy":"1 completed trial, 13 people given it","nulls":0,"nullsWorthShowing":false,"reports":11,"reportedSideEffects":7,"isPeptide":true,"newestStudy":2026},{"slug":"kn069","name":"KN069","fullName":"KN069, dual GLP-1 receptor agonist and GIP receptor antagonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One first study in people, in 48 men.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"mod-grf-1-29","name":"Modified GRF 1-29","fullName":"Modified GRF 1-29, tetrasubstituted human growth hormone releasing factor 1-29","category":"Growth Hormone","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for this compound.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"nad-glutathione","name":"NAD+ with glutathione","fullName":"NAD+ with glutathione (clinic infusion or injection protocol)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One ingredient raises a blood number.","band":"limited","bandWhy":"1 completed trial, 21 people given it","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2026},{"slug":"neurotensin","name":"Neurotensin","fullName":"Neurotensin, the 13 residue NTS gene product","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Neurotensin has been given to people, in a handful of gut studies from the 1980s.","band":"limited","bandWhy":"1 completed trial, 6 people given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2025},{"slug":"noiiglutide","name":"Noiiglutide","fullName":"Noiiglutide (SHR20004), long-acting GLP-1 receptor agonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Published results from a small repeat-dose study in obesity, and a finished final-stage study in type 2 diabetes.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"semaglutide-b12","name":"Semaglutide with B12","fullName":"Compounded semaglutide with cyanocobalamin","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Semaglutide has large studies in people.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"setmelanotide","name":"Setmelanotide","fullName":"Setmelanotide (MC4R agonist)","category":"Melanocortin","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"An FDA-approved shot for rare genetic types of obesity, where a broken gene stops the brain from feeling full.","band":"limited","bandWhy":"1 completed trial, 38 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2022},{"slug":"snap-8","name":"SNAP-8","fullName":"Acetyl Octapeptide-3 (SNAP-8)","category":"Cosmetic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No study has tested SNAP-8 on its own in people.","band":"limited","bandWhy":"1 completed trial, 24 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2024},{"slug":"tirzepatide-b12","name":"Tirzepatide with B12","fullName":"Compounded tirzepatide with cyanocobalamin","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No study of the premix in people.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"ubt251","name":"UBT251","fullName":"UBT251 (GLP-1/GIP/glucagon triple agonist)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A shot that works on three signals, GLP-1, GIP and glucagon, licensed by Novo Nordisk.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"vip","name":"VIP","fullName":"Vasoactive Intestinal Peptide","category":"Healing & Recovery","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A signalling peptide with wide effects on the immune system, swelling and blood flow.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2022},{"slug":"aod-9604","name":"AOD-9604","fullName":"AOD-9604 (modified growth hormone fragment)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"AOD-9604 is one of the few compounds on this site that a company took through real weight-loss studies and finished.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2026},{"slug":"argireline-matrixyl-snap-8","name":"Argireline with Matrixyl and SNAP-8","fullName":"Acetyl hexapeptide-8 with palmitoyl peptides and acetyl octapeptide-3 (topical serum)","category":"Cosmetic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One of the three has a proper study in people.","band":"limited","bandWhy":"1 completed trial, 60 people given it","nulls":1,"nullsWorthShowing":true,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"cortexin","name":"Cortexin","fullName":"Cortexin (polypeptide brain preparation)","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A mix of small brain peptides from cattle, used in Russia for stroke, brain injury and memory problems.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2021},{"slug":"foxo4-dri","name":"FOXO4-DRI","fullName":"FOXO4-DRI (senolytic peptide)","category":"Anti-aging","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No person has been given FOXO4-DRI.","band":"limited","bandWhy":"1 completed trial, 74 people given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2023},{"slug":"lanreotide","name":"Lanreotide","fullName":"Lanreotide (Somatuline), long-acting somatostatin analogue","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A big record as an approved drug for three uses, anchored by a large final-stage trial that tracked how long tumours went without growing.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2014},{"slug":"linaclotide","name":"Linaclotide","fullName":"Linaclotide (Linzess), guanylate cyclase-C agonist","category":"Healing & Recovery","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Several final-stage trials back two adult uses and one use in children.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2018},{"slug":"met-233i","name":"MET-233i","fullName":"MET-233i, once-monthly amylin analog","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Pfizer's monthly amylin shot, from Metsera.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"orexin-a","name":"Orexin-A","fullName":"Orexin-A (hypocretin-1)","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Orexin-A is the brain chemical that keeps you awake.","band":"limited","bandWhy":"1 completed trial, 14 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2014},{"slug":"quad-healing-blend","name":"Quad healing blend","fullName":"Quad healing blend (TB-500 + BPC-157 + KPV + GHK-Cu, low copper ratio)","category":"Healing & Recovery","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for any mix of these four peptides.","band":"limited","bandWhy":"1 completed trial, 13 people given it","nulls":1,"nullsWorthShowing":true,"reports":8,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"semaglutide-bpc-157","name":"Semaglutide with BPC-157","fullName":"Semaglutide with BPC-157 (clinic and grey-market stack)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Only one half has evidence in people, and it was gathered without the other half there.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"semax-selank-dihexa","name":"Semax with selank and dihexa","fullName":"Semax with selank and dihexa (cognitive stack)","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One ingredient has a small study in people against another drug.","band":"limited","bandWhy":"1 completed trial, 62 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2014},{"slug":"testosterone-blends","name":"Testosterone blends","fullName":"Multi-ester testosterone blends (four-ester and similar preparations)","category":"Hormone","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Long use in countries where these are licensed.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":10,"reportedSideEffects":7,"isPeptide":true,"newestStudy":2026},{"slug":"tirzepatide-bpc-157","name":"Tirzepatide with BPC-157","fullName":"Tirzepatide with BPC-157 (clinic and grey-market stack)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One half has a big study in people.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"vosoritide","name":"Vosoritide","fullName":"Vosoritide (Voxzogo), C-type natriuretic peptide analogue","category":"Growth Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A final-stage trial, with a dummy shot for comparison and nobody knowing who got what, showed children grew faster.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2020},{"slug":"endoluten","name":"Endoluten","fullName":"Endoluten, retail pineal peptide complex capsule","category":"Anti-aging","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is human data in this family, and none of it used Endoluten.","band":"preliminary","bandWhy":"3 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2025},{"slug":"bi-1820237","name":"BI 1820237","fullName":"BI 1820237, neuropeptide Y receptor type 2 agonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One published first study in people, with single doses in 95 men.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"bi-3034701","name":"BI 3034701","fullName":"BI 3034701, GLP-1/GIP/NPY2 triple receptor agonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Boehringer Ingelheim's drug that works on three signals: GLP-1, GIP and NPY2, a fullness signal from the gut.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"goserelin","name":"Goserelin","fullName":"Goserelin (GnRH agonist)","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A prescription medicine, not a research peptide.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2010},{"slug":"navepegritide","name":"Navepegritide","fullName":"Navepegritide (TransCon CNP, Yuviwel)","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A weekly shot that slowly releases C-type natriuretic peptide, or CNP.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2026},{"slug":"osteocalcin","name":"Osteocalcin","fullName":"Osteocalcin, bone gamma-carboxyglutamate protein (BGLAP), including undercarboxylated osteocalcin","category":"Hormone","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"All the human data are measurements or genetics.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2021},{"slug":"pl8177","name":"PL8177","fullName":"PL8177, oral MC1R agonist peptide","category":"Melanocortin","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Palatin's peptide pill that switches on MC1R, for ulcerative colitis.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2025},{"slug":"shlp-2","name":"SHLP2","fullName":"SHLP2, small humanin-like peptide 2","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Measuring only.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2024},{"slug":"tb-500","name":"TB-500","fullName":"TB-500 (N-acetylated thymosin beta-4 fragment 17 to 23, Ac-LKKTETQ)","category":"Healing & Recovery","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No published study has given TB-500 to a person.","band":"preliminary","bandWhy":"1 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2026},{"slug":"adropin","name":"Adropin","fullName":"Adropin, the secreted product of the ENHO (energy homeostasis associated) gene","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is a fair amount of human data, and all of it only measures adropin.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2025},{"slug":"calcitonin","name":"Calcitonin","fullName":"Calcitonin (salmon calcitonin)","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A hormone that lowers blood calcium.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2008},{"slug":"gubamy","name":"GUBamy","fullName":"GUB014295 (GUBamy), long-acting amylin analogue","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One finished early safety study in 76 healthy, overweight or obese volunteers, paid for by AbbVie, with no results posted or published.","band":"preliminary","bandWhy":"1 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2026},{"slug":"igf-1-lr3","name":"IGF-1 LR3","fullName":"Long R3 Insulin-like Growth Factor 1","category":"Growth Hormone","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is no evidence in people for IGF-1 LR3.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"mgf","name":"MGF","fullName":"Mechano Growth Factor (IGF-1Ec E-peptide)","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No person has been given lab-made MGF in any published study.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"mitochondrial-plus","name":"Mitochondrial+ blend","fullName":"SS-31 with TB-500 and MOTS-c (Mitochondrial+ blend vial)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The smallest ingredient by weight is the only one with a study in people, and that study failed its main test.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2025},{"slug":"mots-c-ss-31","name":"MOTS-c with SS-31","fullName":"MOTS-c with SS-31 (elamipretide) mitochondrial blend","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One ingredient failed its large final-stage study, with hints of benefit in rare genetic groups.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"pancragen","name":"Pancragen","fullName":"Pancragen (Lys-Glu-Asp-Trp, KEDW)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Pancragen is a four building block peptide from Khavinson's institute in Russia, sold to support the pancreas.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2020},{"slug":"peg-mgf","name":"PEG-MGF","fullName":"Pegylated Mechano Growth Factor","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No person has been given PEG-MGF in any published study, and FDA says so plainly.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"thymogen","name":"Thymogen","fullName":"Thymogen (Glu-Trp dipeptide)","category":"Immune","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A tiny lab-made immune peptide from thymus research, used in Russia to support the immune system.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2024},{"slug":"wolverine","name":"Wolverine blend","fullName":"Wolverine (BPC-157 + TB-500)","category":"Healing & Recovery","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for the pair.","band":"preliminary","bandWhy":"1 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":6,"isPeptide":true,"newestStudy":2026},{"slug":"n-acetyl-semax-amidate","name":"N-Acetyl Semax Amidate","fullName":"N-Acetyl Semax Amidate (NASA)","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is no evidence in people for N-Acetyl Semax Amidate.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2021},{"slug":"5-amino-1mq-slu-pp-332","name":"5-amino-1MQ with SLU-PP-332","fullName":"5-amino-1MQ with SLU-PP-332 (oral metabolic blend)","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is none, for either compound, by any route.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"ac-sdkp","name":"Ac-SDKP","fullName":"N-acetyl-seryl-aspartyl-lysyl-proline (thymosin beta-4 fragment 1-4)","category":"Healing & Recovery","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Ac-SDKP is the first four building blocks of thymosin beta-4.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2021},{"slug":"adipotide","name":"Adipotide","fullName":"Adipotide (FTPP, fat-targeted proapoptotic peptide)","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An experimental peptide that attacks the blood supply of white fat.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2011},{"slug":"ahk-cu","name":"AHK-Cu","fullName":"AHK-Cu (alanine-histidine-lysine copper)","category":"Cosmetic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"AHK-Cu is a copper peptide sold as the hair growth cousin of GHK-Cu.","band":"preclinical","bandWhy":"1 animal study, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2007},{"slug":"alpha-msh","name":"Alpha-MSH","fullName":"Alpha-Melanocyte-Stimulating Hormone","category":"Melanocortin","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The natural hormone behind skin colour, appetite and swelling.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2005},{"slug":"b7-33","name":"B7-33","fullName":"B7-33, single-chain relaxin analog","category":"Healing & Recovery","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"B7-33 is a simpler, lab-made version of the hormone relaxin.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2019},{"slug":"bpc-157-kpv","name":"BPC-157 with KPV","fullName":"BPC-157 with KPV (gut and inflammation blend)","category":"Healing & Recovery","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for the pair.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"bronchogen","name":"Bronchogen","fullName":"Bronchogen (Ala-Glu-Asp-Leu, AEDL)","category":"Immune","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Bronchogen is a four building block peptide from Khavinson's institute, sold for lung health.","band":"preclinical","bandWhy":"2 lab studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2016},{"slug":"brp","name":"BRP","fullName":"BRP (BRINP2-related peptide)","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"BRP is a 12 building block peptide found at Stanford with an AI search of larger hormone proteins.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2025},{"slug":"cartalax","name":"Cartalax","fullName":"Cartalax (Ala-Glu-Asp), cartilage peptide bioregulator","category":"Anti-aging","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No study of Cartalax in people has been found.","band":"preclinical","bandWhy":"4 lab studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2023},{"slug":"chonluten","name":"Chonluten","fullName":"Chonluten (Glu-Asp-Gly, EDG)","category":"Immune","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Chonluten is a three building block peptide from Khavinson's institute, sold for lung and gut lining health.","band":"preclinical","bandWhy":"2 lab studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2022},{"slug":"cortagen","name":"Cortagen","fullName":"Cortagen (Ala-Glu-Asp-Pro, AEDP)","category":"Nootropic & CNS","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Cortagen is a four building block peptide from Khavinson's institute in Russia.","band":"preclinical","bandWhy":"1 animal study, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2020},{"slug":"deadpool-blend","name":"Deadpool blend","fullName":"Deadpool blend (BPC-157 + TB-500 + KPV)","category":"Healing & Recovery","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for the mix.","band":"preclinical","bandWhy":"1 animal study, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"dihexa","name":"Dihexa","fullName":"Dihexa (angiotensin IV analogue)","category":"Nootropic & CNS","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An experimental peptide made from angiotensin, a blood pressure hormone.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2015},{"slug":"dnsp-11","name":"DNSP-11","fullName":"Dopamine neuron stimulating peptide-11, an 11 amino acid peptide from the GDNF pro-region","category":"Nootropic & CNS","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None.","band":"preclinical","bandWhy":"4 animal studies, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2018},{"slug":"fgl","name":"FGL","fullName":"FG Loop Peptide (NCAM-derived)","category":"Nootropic & CNS","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A peptide from a protein that helps nerve cells stick together.","band":"preclinical","bandWhy":"3 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2007},{"slug":"gb-115","name":"GB-115","fullName":"GB-115, cholecystokinin-4 dipeptide analog","category":"Nootropic & CNS","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"GB-115 is a Russian anti-anxiety pill made of two building blocks.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2013},{"slug":"ghrp-1","name":"GHRP-1","fullName":"Growth Hormone Releasing Peptide 1","category":"Growth Hormone","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One of the first lab-made peptides that make the body release growth hormone.","band":"preclinical","bandWhy":"1 animal study, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":1998},{"slug":"glp-2","name":"GLP-2","fullName":"Glucagon-Like Peptide-2 (native intestinal hormone)","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A natural gut hormone that helps the gut lining grow and heal.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2014},{"slug":"hgh-fragment-176-191","name":"HGH Fragment 176-191","fullName":"Growth Hormone Fragment 176-191","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No study of this fragment in people has ever been published under this name.","band":"preclinical","bandWhy":"4 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2026},{"slug":"igf-1-des","name":"IGF-1 DES","fullName":"Des(1-3)IGF-1","category":"Muscle & Performance","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"IGF-1 DES is IGF-1 with its first three building blocks cut off.","band":"preclinical","bandWhy":"2 lab studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":true,"newestStudy":1996},{"slug":"kpv","name":"KPV","fullName":"KPV (lysine-proline-valine, alpha-MSH fragment)","category":"Healing & Recovery","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is no evidence in people for KPV.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2026},{"slug":"livagen","name":"Livagen","fullName":"Livagen (Lys-Glu-Asp-Ala, KEDA)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Livagen is a four building block peptide from Khavinson's institute, sold for liver and gut health.","band":"preclinical","bandWhy":"2 lab studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":true,"newestStudy":2020},{"slug":"nesfatin-1","name":"Nesfatin-1","fullName":"Nesfatin-1, the 82 residue NUCB2-derived peptide","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Sold as a weight-loss peptide, but no published study has ever given it to a person.","band":"preclinical","bandWhy":"1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":true,"newestStudy":2024},{"slug":"ovagen","name":"Ovagen","fullName":"Ovagen, marketed liver and gastrointestinal peptide bioregulator","category":"Anti-aging","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is no evidence in people for Ovagen, and none in animals either.","band":"preclinical","bandWhy":"1 animal study, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2023},{"slug":"p21","name":"P21","fullName":"P21 (P021, CNTF-derived peptide)","category":"Nootropic & CNS","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No person has ever been given P21.","band":"preclinical","bandWhy":"5 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"pda-tb-500","name":"PDA with TB-500","fullName":"Pentadeca arginate with TB-500","category":"Healing & Recovery","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for the blend, none for PDA under its own name, and none for the TB-500 piece in the other half.","band":"preclinical","bandWhy":"1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2026},{"slug":"pe-22-28","name":"PE-22-28","fullName":"PE-22-28 (spadin analogue)","category":"Nootropic & CNS","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An experimental peptide studied in mice for fast antidepressant effects and new brain cell growth.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2017},{"slug":"pentadeca-arginate","name":"Pentadeca Arginate","fullName":"Pentadeca Arginate (PDA, pentadecapeptide arginate)","category":"Healing & Recovery","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nothing has been measured under this name, in people or in any animal.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":true,"newestStudy":2026},{"slug":"pnc-27","name":"PNC-27","fullName":"PNC-27, p53-derived membrane-active peptide","category":"Immune","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"PNC-27 is a peptide that bursts cancer cells in a dish.","band":"preclinical","bandWhy":"1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2019},{"slug":"ptd-dbm","name":"PTD-DBM","fullName":"PTD-DBM (protein transduction domain, Dishevelled-binding motif)","category":"Cosmetic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"PTD-DBM is a peptide you put on the scalp.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2017},{"slug":"somatostatin","name":"Somatostatin","fullName":"Somatostatin (growth hormone inhibiting hormone)","category":"Growth Hormone","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The body's natural off switch for growth hormone.","band":"preclinical","bandWhy":"1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":1999},{"slug":"ss-20","name":"SS-20","fullName":"SS-20 (Phe-D-Arg-Phe-Lys-NH2), Szeto-Schiller mitochondria-targeted peptide","category":"Antioxidant","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"SS-20 has never been given to a person in a published study.","band":"preclinical","bandWhy":"4 animal studies, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2018},{"slug":"thymulin","name":"Thymulin","fullName":"Thymulin (zinc-dependent thymic hormone)","category":"Immune","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A thymus hormone that needs zinc to work.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":true,"newestStudy":2014},{"slug":"vilon","name":"Vilon","fullName":"Vilon (Lys-Glu dipeptide bioregulator)","category":"Anti-aging","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A tiny lab-made peptide from Khavinson's group, studied for the immune system and ageing.","band":"preclinical","bandWhy":"1 animal study, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":true,"newestStudy":2013},{"slug":"cardiogen","name":"Cardiogen","fullName":"Cardiogen (Ala-Glu-Asp-Arg peptide bioregulator)","category":"Anti-aging","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A lab-made peptide from Russian research, aimed at the heart and blood vessels as they age.","band":"none","bandWhy":"no study cited on this page yet","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":true,"newestStudy":2022},{"slug":"nattokinase","name":"Nattokinase","fullName":"Nattokinase (Subtilisin NAT)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nattokinase has more human data than almost anything else on this site.","band":"strong","bandWhy":"9 completed trials, 1,795 people given it","nulls":3,"nullsWorthShowing":true,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2026},{"slug":"orforglipron","name":"Orforglipron","fullName":"Orforglipron (Foundayo, oral non-peptide GLP-1 agonist)","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Orforglipron is by far the most tested compound in this group.","band":"strong","bandWhy":"8 completed trials, 17,383 people given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2026},{"slug":"albiglutide","name":"Albiglutide","fullName":"Albiglutide (Tanzeum, Eperzan), once-weekly GLP-1 receptor agonist fused to human albumin","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"One of the largest human records of any drug on this site.","band":"strong","bandWhy":"2 completed trials, 10,304 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2024},{"slug":"niacin","name":"Niacin","fullName":"Nicotinic acid, niacin, the acid form of vitamin B3","category":"Longevity","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"By far the biggest body of human evidence of anything in the NAD pathway.","band":"strong","bandWhy":"2 completed trials, 29,087 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2024},{"slug":"omega-3","name":"Omega-3","fullName":"Long-chain omega-3 fatty acids (EPA and DHA)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A very large set of human studies, with results that depend on the dose and the product.","band":"strong","bandWhy":"3 completed trials, 34,050 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2021},{"slug":"vitamin-d","name":"Vitamin D","fullName":"Cholecalciferol (vitamin D3)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One of the biggest sets of human studies for any supplement, from tens of thousands of people in several countries.","band":"strong","bandWhy":"2 completed trials, 25,871 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2022},{"slug":"empagliflozin","name":"Empagliflozin","fullName":"Empagliflozin (sodium-glucose cotransporter 2 inhibitor)","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Strong for heart, kidney and blood sugar disease.","band":"strong","bandWhy":"3 completed trials, 16,738 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2024},{"slug":"erythropoietin","name":"Erythropoietin","fullName":"Erythropoietin (EPO), epoetin alfa and darbepoetin alfa","category":"Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Large studies, and mostly a warning.","band":"strong","bandWhy":"3 completed trials, 4,641 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2023},{"slug":"zoledronic-acid","name":"Zoledronic acid","fullName":"Zoledronic acid, an intravenous nitrogen-containing bisphosphonate","category":"Longevity","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Zoledronic acid has a lot of human data from proper studies, all gathered to answer a question about bones.","band":"strong","bandWhy":"4 completed trials, 7,176 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2023},{"slug":"botulinum-toxin-type-a","name":"Botulinum toxin type A","fullName":"Botulinum neurotoxin type A (Botox, Dysport, Xeomin, Jeuveau, Daxxify)","category":"Cosmetic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"One of the most tested shots in medicine.","band":"strong","bandWhy":"2 completed trials, 1,681 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2024},{"slug":"egcg","name":"EGCG","fullName":"Epigallocatechin-3-gallate, the principal catechin of green tea","category":"Antioxidant","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A lot of human data, and unusually useful about harm.","band":"strong","bandWhy":"3 completed trials, 1,172 people given it","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2018},{"slug":"enalapril","name":"Enalapril","fullName":"Enalapril maleate (angiotensin-converting enzyme inhibitor)","category":"Longevity","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Lots for heart failure and blood pressure, none for ageing.","band":"strong","bandWhy":"2 completed trials, 2,822 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2024},{"slug":"everolimus","name":"Everolimus","fullName":"Everolimus, mTOR inhibitor and rapamycin analogue","category":"Longevity","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"A large record as an approved cancer and transplant drug.","band":"strong","bandWhy":"3 completed trials, 1,024 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2021},{"slug":"hydralazine","name":"Hydralazine","fullName":"Hydralazine, vasodilator and NRF2 pathway activator","category":"Longevity","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"A long record as an approved drug for high blood pressure and heart failure, with one well-known immune risk.","band":"strong","bandWhy":"3 completed trials, 1,724 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2017},{"slug":"lorecivivint","name":"Lorecivivint","fullName":"Lorecivivint (SM04690)","category":"Healing & Recovery","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A knee shot for arthritis that aims to slow cartilage loss.","band":"strong","bandWhy":"2 completed trials, 1,011 people given it","nulls":1,"nullsWorthShowing":true,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"dulaglutide","name":"Dulaglutide","fullName":"Dulaglutide (GLP-1 receptor agonist)","category":"Metabolic","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A once-a-week shot for type 2 diabetes.","band":"strong","bandWhy":"2 completed trials, 10,500 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2019},{"slug":"efpeglenatide","name":"Efpeglenatide","fullName":"Efpeglenatide (long-acting GLP-1 receptor agonist)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An experimental long-lasting GLP-1 drug that lowered heart and kidney problems in a large study.","band":"strong","bandWhy":"2 completed trials, 4,076 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2022},{"slug":"methotrexate","name":"Methotrexate","fullName":"Methotrexate, folate antimetabolite and anti-inflammatory","category":"Immune","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A very large record in inflammatory disease, plus one big heart trial in people that came up empty.","band":"strong","bandWhy":"2 completed trials, 5,022 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2026},{"slug":"pioglitazone","name":"Pioglitazone","fullName":"Pioglitazone (Actos), thiazolidinedione PPAR-gamma agonist","category":"Metabolic","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Lots.","band":"strong","bandWhy":"2 completed trials, 9,114 people given it","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2026},{"slug":"simvastatin","name":"Simvastatin","fullName":"Simvastatin, HMG-CoA reductase inhibitor","category":"Longevity","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"One of the best-tested drugs in medicine for heart attacks and strokes.","band":"strong","bandWhy":"2 completed trials, 24,980 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2011},{"slug":"trametinib","name":"Trametinib","fullName":"Trametinib, MEK inhibitor","category":"Longevity","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A large cancer record, with well known and serious side effects.","band":"strong","bandWhy":"2 completed trials, 1,192 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2025},{"slug":"resveratrol","name":"Resveratrol","fullName":"Resveratrol (trans-3,5,4'-trihydroxystilbene)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Resveratrol has one of the biggest human trial records of anything on this site.","band":"moderate","bandWhy":"14 completed trials, 403 people given it","nulls":8,"nullsWorthShowing":true,"reports":7,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2026},{"slug":"cebranopadol","name":"Cebranopadol","fullName":"Cebranopadol (GRT-6005), oral dual nociceptin/orphanin FQ peptide receptor and mu-opioid receptor agonist (a small molecule, not a peptide)","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Several thousand people, in studies from early safety tests to final-stage trials.","band":"moderate","bandWhy":"5 completed trials, 300 people given it","nulls":2,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"leptin","name":"Leptin","fullName":"Leptin (with metreleptin, Myalept, the approved recombinant analogue)","category":"Metabolic","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"There is a lot of human evidence, but it splits by who was studied.","band":"moderate","bandWhy":"6 completed trials, 844 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2018},{"slug":"metformin","name":"Metformin","fullName":"Metformin hydrochloride (biguanide)","category":"Longevity","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Huge for diabetes, almost none for ageing.","band":"moderate","bandWhy":"3 completed trials, 489 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2023},{"slug":"sulforaphane","name":"Sulforaphane","fullName":"Sulforaphane, an isothiocyanate released from broccoli glucoraphanin","category":"Antioxidant","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Large for a supplement.","band":"moderate","bandWhy":"7 completed trials, 423 people given it","nulls":1,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2025},{"slug":"therapeutic-plasma-exchange","name":"Therapeutic Plasma Exchange","fullName":"Therapeutic plasma exchange (plasmapheresis with albumin or albumin plus immunoglobulin replacement)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A lot, by this site's standards.","band":"moderate","bandWhy":"5 completed trials, 389 people given it","nulls":1,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2025},{"slug":"gdf-15","name":"GDF15","fullName":"Growth/differentiation factor 15","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Both directions have been tested in people.","band":"moderate","bandWhy":"2 completed trials, 313 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2025},{"slug":"oveporexton","name":"Oveporexton","fullName":"Oveporexton (TAK-861), oral orexin receptor 2 selective agonist","category":"Nootropic & CNS","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Two 12 week studies of 273 people against a dummy pill, one earlier 8 week study of 112 people, and an FDA label built on them.","band":"moderate","bandWhy":"6 completed trials, 441 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"idebenone","name":"Idebenone","fullName":"Idebenone, short-chain synthetic benzoquinone analogue of coenzyme Q10","category":"Antioxidant","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Idebenone has been through several proper studies against a dummy.","band":"moderate","bandWhy":"5 completed trials, 732 people given it","nulls":2,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2024},{"slug":"telaglenastat","name":"Telaglenastat","fullName":"Telaglenastat (CB-839), oral glutaminase 1 inhibitor","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A lot of data, from proper studies, all in cancer.","band":"moderate","bandWhy":"3 completed trials, 513 people given it","nulls":1,"nullsWorthShowing":true,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"creatine","name":"Creatine","fullName":"Creatine monohydrate","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Huge.","band":"moderate","bandWhy":"3 completed trials, 168 people given it","nulls":2,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2025},{"slug":"fgf21","name":"FGF21","fullName":"Fibroblast growth factor 21 (native hormone)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The human studies tested lab-built versions, not the natural hormone.","band":"moderate","bandWhy":"2 completed trials, 350 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2026},{"slug":"landogrozumab","name":"Landogrozumab","fullName":"Landogrozumab (LY2495655), anti-myostatin monoclonal antibody","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The best-designed test of blocking myostatin, in the people the idea is meant to help.","band":"moderate","bandWhy":"3 completed trials, 726 people given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2015},{"slug":"low-dose-lithium","name":"Low-dose lithium","fullName":"Lithium at subtherapeutic and trace doses, including lithium orotate","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two very different kinds of human data that often get blended.","band":"moderate","bandWhy":"3 completed trials, 106 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2025},{"slug":"mib-626","name":"MIB-626","fullName":"MIB-626, a microcrystalline polymorph of beta-nicotinamide mononucleotide","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Three studies with a dummy pill group, about 104 people in all.","band":"moderate","bandWhy":"4 completed trials, 107 people given it","nulls":2,"nullsWorthShowing":true,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"mitoglitazone","name":"Mitoglitazone","fullName":"Mitoglitazone (MSDC-0160, PPAR-gamma-sparing thiazolidinedione, mitochondrial pyruvate carrier modulator)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two finished mid-stage trials, both run by the maker, both with results posted.","band":"moderate","bandWhy":"2 completed trials, 385 people given it","nulls":1,"nullsWorthShowing":true,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"myostatin","name":"Myostatin","fullName":"Myostatin (growth/differentiation factor 8)","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A lot of human trials, and mostly a record of failure for the obvious approach.","band":"moderate","bandWhy":"3 completed trials, 188 people given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2025},{"slug":"navitoclax","name":"Navitoclax","fullName":"Navitoclax (ABT-263), oral BCL-2, BCL-xL and BCL-w inhibitor","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is a lot of data in people, all of it in cancer patients, and none about ageing or worn-out cells.","band":"moderate","bandWhy":"2 completed trials, 137 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"nicotinamide","name":"Nicotinamide","fullName":"Nicotinamide, the amide form of vitamin B3","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Unusually good for a vitamin, and almost all of it is about something other than ageing.","band":"moderate","bandWhy":"4 completed trials, 591 people given it","nulls":4,"nullsWorthShowing":true,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2023},{"slug":"pqq","name":"PQQ","fullName":"Pyrroloquinoline quinone, usually sold as the disodium salt","category":"Antioxidant","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"PQQ has been tested in people several times, in studies of 23 to 64 people, mostly paid for by industry.","band":"moderate","bandWhy":"3 completed trials, 116 people given it","nulls":2,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2024},{"slug":"spermidine","name":"Spermidine","fullName":"Spermidine","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A year-long memory study missed.","band":"moderate","bandWhy":"2 completed trials, 130 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2024},{"slug":"ubx0101","name":"UBX0101","fullName":"UBX0101, intra-articular MDM2 to p53 interaction inhibitor (Unity Biotechnology)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Four registered studies in knee arthritis: two early safety studies, one larger study with results posted to the US registry, and a long-term follow-…","band":"moderate","bandWhy":"1 completed trial, 183 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2026},{"slug":"berberine","name":"Berberine","fullName":"Berberine hydrochloride","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The biggest set of human studies of any blood sugar supplement on this site.","band":"moderate","bandWhy":"3 completed trials, 186 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2023},{"slug":"betaine","name":"Betaine","fullName":"Betaine (trimethylglycine), a methyl donor and osmolyte","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A lot of data, and it contradicts itself in a useful way.","band":"moderate","bandWhy":"3 completed trials, 170 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2021},{"slug":"bromantane","name":"Bromantane","fullName":"N-(2-adamantyl)-N-(para-bromophenyl)amine","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There are real human studies with a dummy-pill comparison.","band":"moderate","bandWhy":"3 completed trials, 728 people given it","nulls":1,"nullsWorthShowing":true,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2012},{"slug":"coq10","name":"CoQ10","fullName":"Coenzyme Q10 (ubiquinone and ubiquinol)","category":"Antioxidant","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One strong study in a specific group of sick people, and a clear failure for the most common reason people take it.","band":"moderate","bandWhy":"2 completed trials, 162 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2020},{"slug":"curcumin","name":"Curcumin","fullName":"Curcumin (diferuloylmethane from Curcuma longa)","category":"Antioxidant","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A large set of human studies with steady effects on swelling and blood sugar markers.","band":"moderate","bandWhy":"3 completed trials, 195 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2024},{"slug":"dhea","name":"DHEA","fullName":"Dehydroepiandrosterone, adrenal androgen precursor","category":"Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Tested a lot as an anti-ageing pill, with weak results.","band":"moderate","bandWhy":"3 completed trials, 267 people given it","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2019},{"slug":"ecdysterone","name":"Ecdysterone","fullName":"Ecdysterone (20-hydroxyecdysone), plant and insect ecdysteroid","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Good for a supplement in this group.","band":"moderate","bandWhy":"3 completed trials, 233 people given it","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2025},{"slug":"efimosfermin","name":"Efimosfermin alfa","fullName":"Efimosfermin alfa (BOS-580)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"GSK's monthly copy of FGF21, a liver hormone.","band":"moderate","bandWhy":"2 completed trials, 186 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"enobosarm","name":"Enobosarm","fullName":"Enobosarm (ostarine, GTx-024, MK-2866)","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The drug sold on the grey market as ostarine.","band":"moderate","bandWhy":"1 completed trial, 159 people given it","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"hrs-7535","name":"HRS-7535","fullName":"HRS-7535 (KAI-7535), oral GLP-1 receptor agonist","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Hengrui's daily GLP-1 pill.","band":"moderate","bandWhy":"2 completed trials, 235 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"nrpt","name":"NRPT","fullName":"Nicotinamide riboside with pterostilbene, sold as Basis","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Three published studies with a dummy pill group, 176 people in all.","band":"moderate","bandWhy":"3 completed trials, 176 people given it","nulls":2,"nullsWorthShowing":true,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2022},{"slug":"rtb101","name":"RTB101","fullName":"RTB101 (dactolisib, BEZ235), low-dose TORC1 inhibitor","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An unusually complete human programme.","band":"moderate","bandWhy":"1 completed trial, 1,024 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2021},{"slug":"stamulumab","name":"Stamulumab","fullName":"Stamulumab (MYO-029), anti-myostatin monoclonal antibody","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One study in 116 adults, built to check safety rather than prove benefit.","band":"moderate","bandWhy":"2 completed trials, 122 people given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2009},{"slug":"supaglutide","name":"Supaglutide","fullName":"Supaglutide, GLP-1 and IgG2 Fc fusion protein, approved as efsubaglutide alfa","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two diabetes studies with more than 700 adults in total, each with a dummy-shot group.","band":"moderate","bandWhy":"3 completed trials, 190 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"taurine","name":"Taurine","fullName":"Taurine (2-aminoethanesulfonic acid)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Thin, and the starting idea is in dispute.","band":"moderate","bandWhy":"1 completed trial, 120 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2025},{"slug":"azithromycin-roxithromycin","name":"Azithromycin and roxithromycin","fullName":"Azithromycin and roxithromycin, macrolide antibiotics proposed as senolytics","category":"Anti-aging","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"No person has been given either drug to clear zombie cells in a study.","band":"moderate","bandWhy":"1 completed trial, 480 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2018},{"slug":"bimagrumab","name":"Bimagrumab","fullName":"Bimagrumab (anti-activin receptor antibody)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An antibody shot that takes the brake off muscle growth.","band":"moderate","bandWhy":"2 completed trials, 507 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"bio101","name":"BIO101","fullName":"BIO101, pharmaceutical-grade 20-hydroxyecdysone and MAS receptor activator","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One well-run study in 233 older adults, measuring walking speed, hurt by Covid.","band":"moderate","bandWhy":"1 completed trial, 233 people given it","nulls":1,"nullsWorthShowing":true,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2025},{"slug":"bptes","name":"BPTES","fullName":"BPTES, allosteric inhibitor of glutaminase 1 (GLS1)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for BPTES.","band":"moderate","bandWhy":"2 completed trials, 513 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2025},{"slug":"cardiac-glycosides","name":"Cardiac glycosides","fullName":"Cardiac glycosides as senolytics (ouabain, digoxin, digitoxin, proscillaridin A)","category":"Longevity","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Two separate things that must not be mixed up.","band":"moderate","bandWhy":"1 completed trial, 6,800 people given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"carnosine","name":"Carnosine","fullName":"Carnosine (beta-alanyl-L-histidine), endogenous dipeptide sold as a supplement","category":"Antioxidant","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One large study of carnosine itself that found no difference on any planned test, with a couple of wins only inside age and sex groups.","band":"moderate","bandWhy":"2 completed trials, 299 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2026},{"slug":"dersimelagon","name":"Dersimelagon","fullName":"Dersimelagon (MT-7117)","category":"Melanocortin","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A daily pill that switches on MC1R, the skin's tanning receptor.","band":"moderate","bandWhy":"1 completed trial, 165 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"efruxifermin","name":"Efruxifermin","fullName":"Efruxifermin (EFX, AKR-001)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A weekly shot that copies FGF21, a liver hormone.","band":"moderate","bandWhy":"1 completed trial, 181 people given it","nulls":1,"nullsWorthShowing":true,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"green-tea-extract","name":"Green tea extract","fullName":"Green tea extract (Camellia sinensis catechin concentrate, EGCG-rich)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A lot, and mostly about weight and safety, not ageing.","band":"moderate","bandWhy":"1 completed trial, 1,075 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2024},{"slug":"mifepristone","name":"Mifepristone","fullName":"Mifepristone (RU-486), glucocorticoid and progesterone receptor antagonist","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A long record as an approved drug for two unrelated uses, and nothing at all on ageing.","band":"moderate","bandWhy":"2 completed trials, 320 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2026},{"slug":"minocycline","name":"Minocycline","fullName":"Minocycline, second-generation tetracycline antibiotic","category":"Longevity","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A lot of human data, and mostly bad news outside skin care.","band":"moderate","bandWhy":"2 completed trials, 966 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2020},{"slug":"mycophenolic-acid","name":"Mycophenolic acid","fullName":"Mycophenolic acid, inosine monophosphate dehydrogenase inhibitor","category":"Immune","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A large record as an approved drug in transplants and autoimmune disease, with serious known harms.","band":"moderate","bandWhy":"2 completed trials, 227 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2024},{"slug":"oxaloacetate","name":"Oxaloacetate","fullName":"Oxaloacetate, anhydrous enol-oxaloacetic acid","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two small, short studies with about 112 people in total.","band":"moderate","bandWhy":"2 completed trials, 112 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2024},{"slug":"ruxolitinib","name":"Ruxolitinib","fullName":"Ruxolitinib, a JAK1 and JAK2 inhibitor used as a senomorphic","category":"Anti-aging","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"There is a lot of human evidence, and none of it is about ageing.","band":"moderate","bandWhy":"1 completed trial, 309 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2017},{"slug":"sodium-phenylbutyrate","name":"Sodium phenylbutyrate","fullName":"Sodium phenylbutyrate (4-phenylbutyrate), chemical chaperone and HDAC inhibitor","category":"Longevity","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Approved for a rare metabolic disease, with a separate and telling history in ALS.","band":"moderate","bandWhy":"2 completed trials, 148 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2024},{"slug":"testosterone","name":"Testosterone","fullName":"Testosterone, the principal androgen","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Some of the best proof on this site.","band":"moderate","bandWhy":"1 completed trial, 5,246 people given it","nulls":0,"nullsWorthShowing":false,"reports":10,"reportedSideEffects":6,"isPeptide":false,"newestStudy":2026},{"slug":"aicar","name":"AICAR","fullName":"AICAR (acadesine)","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"AICAR was the first exercise in a pill, from a 2008 mouse paper.","band":"moderate","bandWhy":"1 completed trial, 3,080 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2012},{"slug":"exosomes","name":"Exosomes","fullName":"Exosomes and small extracellular vesicles","category":"Healing & Recovery","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One well-run study in people with a strong result, for one product used one way.","band":"moderate","bandWhy":"1 completed trial, 110 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2025},{"slug":"mct-oil","name":"MCT oil","fullName":"Medium-chain triglyceride oil","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A fair amount of human research on body make-up, and one sizable Alzheimer's study where the benefit showed up mostly in people without a certain gen…","band":"moderate","bandWhy":"1 completed trial, 152 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2015},{"slug":"selenium","name":"Selenium","fullName":"Selenium (selenomethionine and related salts)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The biggest prevention trial here found no benefit.","band":"moderate","bandWhy":"1 completed trial, 35,533 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2009},{"slug":"testosterone-cypionate","name":"Testosterone cypionate","fullName":"Testosterone cypionate, long-chain injectable ester","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Decades of approved use, and it is well known how the drug moves through the body.","band":"moderate","bandWhy":"1 completed trial, 5,246 people given it","nulls":0,"nullsWorthShowing":false,"reports":9,"reportedSideEffects":6,"isPeptide":false,"newestStudy":2026},{"slug":"clenbuterol","name":"Clenbuterol","fullName":"Clenbuterol hydrochloride, selective beta-2 adrenergic agonist","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is real human data: one controlled study where healthy men took the drug and a dummy in turn, one small study in heart failure patients, a stud…","band":"limited","bandWhy":"2 completed trials, 11 people given it","nulls":2,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2025},{"slug":"epicatechin","name":"Epicatechin","fullName":"Epicatechin (cocoa flavan-3-ol)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Real but small.","band":"limited","bandWhy":"4 completed trials, 44 people given it","nulls":2,"nullsWorthShowing":true,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"danazol","name":"Danazol","fullName":"Danazol (synthetic attenuated androgen, ethisterone derivative)","category":"Hormone","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"One small study in inherited telomere disease that found longer telomeres.","band":"limited","bandWhy":"3 completed trials, 63 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2026},{"slug":"nicotinamide-riboside","name":"Nicotinamide Riboside","fullName":"Nicotinamide Riboside (NR)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"NR reliably raises NAD in the blood.","band":"limited","bandWhy":"4 completed trials, 90 people given it","nulls":1,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2024},{"slug":"nomlabofusp","name":"Nomlabofusp","fullName":"Nomlabofusp (CTI-1601), recombinant frataxin fused to a cell penetrating peptide, for Friedreich ataxia","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"55 adults took part in two early studies that compared it with a dummy shot.","band":"limited","bandWhy":"2 completed trials, 28 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"tudca","name":"TUDCA","fullName":"Tauroursodeoxycholic acid, the taurine conjugate of ursodeoxycholic acid","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Real but narrow.","band":"limited","bandWhy":"3 completed trials, 54 people given it","nulls":2,"nullsWorthShowing":true,"reports":7,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2024},{"slug":"17-dmag","name":"17-DMAG","fullName":"17-Dimethylaminoethylamino-17-demethoxygeldanamycin (alvespimycin, HSP90 inhibitor)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Early cancer studies only.","band":"limited","bandWhy":"2 completed trials, 49 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2024},{"slug":"ard-101","name":"ARD-101","fullName":"ARD-101, gut-restricted bitter taste receptor (TAS2R) agonist","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One published study showing less hunger in people, and one small finished study, against two stopped final-stage studies in the main target disorder.","band":"limited","bandWhy":"1 completed trial, 20 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"bivamelagon","name":"Bivamelagon","fullName":"Bivamelagon (LB54640), oral melanocortin-4 receptor agonist","category":"Melanocortin","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"At least 140 people have taken bivamelagon across two studies.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"danuglipron","name":"Danuglipron","fullName":"Danuglipron (oral small-molecule GLP-1 agonist)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Pfizer's daily GLP-1 pill.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2025},{"slug":"dasatinib","name":"Dasatinib","fullName":"Dasatinib (senolytic; approved leukemia drug)","category":"Longevity","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"An approved leukemia drug also tried, with quercetin, to clear worn-out cells.","band":"limited","bandWhy":"3 completed trials, 74 people given it","nulls":1,"nullsWorthShowing":true,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2024},{"slug":"dt2216","name":"DT2216","fullName":"DT2216, VHL-recruiting PROTAC degrader of BCL-xL","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One published first study in 20 people with solid cancers, plus registry records for two more cancer studies.","band":"limited","bandWhy":"1 completed trial, 20 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"irisin","name":"Irisin","fullName":"Irisin (cleaved ectodomain of fibronectin type III domain-containing protein 5, FNDC5)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nobody has ever given irisin to a person.","band":"limited","bandWhy":"1 completed trial, 7 people given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"mibavademab","name":"Mibavademab","fullName":"Mibavademab (REGN4461), leptin receptor agonist antibody","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An early human study, compared with a dummy shot, with a clear result that depended on who got it.","band":"limited","bandWhy":"2 completed trials, 1 person given it","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"nmn","name":"NMN","fullName":"Nicotinamide Mononucleotide","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"NAD in the blood goes up.","band":"limited","bandWhy":"4 completed trials, 94 people given it","nulls":3,"nullsWorthShowing":true,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2023},{"slug":"quercetin","name":"Quercetin","fullName":"Quercetin (senolytic flavonoid)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A plant compound in many foods, used with the drug dasatinib to clear worn-out cells.","band":"limited","bandWhy":"3 completed trials, 60 people given it","nulls":1,"nullsWorthShowing":true,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2024},{"slug":"1-3-butanediol","name":"(R/S)-1,3-Butanediol","fullName":"(R/S)-1,3-Butanediol (racemic ketone precursor, beta-hydroxybutyrate prodrug)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Short-term studies of metabolism and how well people handle it.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2024},{"slug":"ambroxol","name":"Ambroxol","fullName":"Ambroxol (mucolytic, glucocerebrosidase pharmacological chaperone)","category":"Anti-aging","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two studies in Parkinson's disease, with 55 and 23 people.","band":"limited","bandWhy":"2 completed trials, 73 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2025},{"slug":"collagen-peptides","name":"Collagen peptides","fullName":"Hydrolysed collagen peptides","category":"Cosmetic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Lots of studies, with the same hole in how they were built.","band":"limited","bandWhy":"2 completed trials, 69 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2020},{"slug":"dimethyl-fumarate","name":"Dimethyl fumarate","fullName":"Dimethyl fumarate (Tecfidera), NRF2 pathway activator","category":"Antioxidant","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"A solid record as an approved drug for multiple sclerosis and psoriasis.","band":"limited","bandWhy":"3 completed trials, 54 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2024},{"slug":"domagrozumab","name":"Domagrozumab","fullName":"Domagrozumab (PF-06252616), anti-myostatin monoclonal antibody","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A well-built study with a real-world main test that found nothing.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2020},{"slug":"methylene-blue","name":"Methylene Blue","fullName":"Methylene blue (methylthioninium chloride)","category":"Antioxidant","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Methylene blue is an FDA-approved antidote for a rare blood problem called methemoglobinemia.","band":"limited","bandWhy":"1 completed trial, 26 people given it","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2018},{"slug":"mk-677","name":"MK-677","fullName":"Ibutamoren (oral ghrelin receptor agonist)","category":"Growth Hormone","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A daily pill that raises growth hormone and IGF-1.","band":"limited","bandWhy":"2 completed trials, 65 people given it","nulls":1,"nullsWorthShowing":true,"reports":11,"reportedSideEffects":7,"isPeptide":false,"newestStudy":2011},{"slug":"nac","name":"NAC","fullName":"N-Acetylcysteine","category":"Antioxidant","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"NAC is what the body uses to make glutathione.","band":"limited","bandWhy":"2 completed trials, 15 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2025},{"slug":"nandrolone-decanoate","name":"Nandrolone decanoate","fullName":"Nandrolone decanoate, injectable 19-nortestosterone ester","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Studies in people across three groups whose bodies were wasting, plus a review that pooled studies in women with thin bones after menopause.","band":"limited","bandWhy":"3 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2025},{"slug":"rapamycin","name":"Rapamycin","fullName":"Rapamycin (Sirolimus, mTOR inhibitor)","category":"Longevity","tier":"many","usLegal":"approved","usLabel":"Approved","humanLine":"Two small studies of rapamycin itself in older adults, plus a flu shot study of a related drug.","band":"limited","bandWhy":"2 completed trials, 25 people given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2025},{"slug":"trontinemab","name":"Trontinemab","fullName":"Trontinemab (RG6102), Brainshuttle anti-amyloid antibody","category":"Nootropic & CNS","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Roche's anti-amyloid antibody with a shuttle that carries it into the brain.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2025},{"slug":"urolithin-a","name":"Urolithin A","fullName":"Urolithin A","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Three studies in people.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2022},{"slug":"young-plasma-infusion","name":"Young Plasma Infusion","fullName":"Young donor plasma infusion (transfusion of plasma from young adult donors)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One small proper trial exists, and it was sized to check safety, not benefit.","band":"limited","bandWhy":"1 completed trial, 18 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2022},{"slug":"ace-031","name":"ACE-031","fullName":"ACE-031 (soluble activin receptor type IIB)","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A decoy that traps myostatin and activin, studied for muscular dystrophy.","band":"limited","bandWhy":"1 completed trial, 48 people given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2017},{"slug":"aleniglipron","name":"Aleniglipron","fullName":"Aleniglipron (GSBR-1290)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A daily GLP-1 pill from Structure Therapeutics.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"alpha-2-macroglobulin","name":"Alpha-2-Macroglobulin","fullName":"Alpha-2-macroglobulin (A2M)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One proper trial exists, and its comparison between groups found nothing.","band":"limited","bandWhy":"1 completed trial, 75 people given it","nulls":1,"nullsWorthShowing":true,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2024},{"slug":"alpha-lipoic-acid","name":"Alpha-Lipoic Acid","fullName":"Alpha-Lipoic Acid (ALA, thioctic acid)","category":"Antioxidant","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An antioxidant studied for nerve pain in diabetes and for metabolic health.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2011},{"slug":"ashwagandha","name":"Ashwagandha","fullName":"Ashwagandha (Withania somnifera root extract)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There are trials, tested against a dummy pill, showing standardized root extracts help how people feel.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2019},{"slug":"bge-102","name":"BGE-102","fullName":"BGE-102, oral NLRP3 inflammasome inhibitor","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"BioAge's daily pill that blocks NLRP3, a trigger of long-term inflammation.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"buntanetap","name":"Buntanetap","fullName":"Buntanetap (posiphen, ANVS401)","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A pill that cuts how much amyloid, tau and alpha-synuclein the brain makes, all at once.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"elecoglipron","name":"Elecoglipron","fullName":"Elecoglipron (AZD5004, ECC5004)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"AstraZeneca's daily GLP-1 pill.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"follistatin","name":"Follistatin","fullName":"Follistatin (myostatin/activin antagonist)","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A natural protein that blocks myostatin and activin, two brakes on muscle growth.","band":"limited","bandWhy":"2 completed trials, 12 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2017},{"slug":"forskolin","name":"Forskolin","fullName":"Forskolin, labdane diterpene from Coleus forskohlii","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two 12-week studies from 2005 with 53 people in total, each with a dummy-pill group.","band":"limited","bandWhy":"2 completed trials, 53 people given it","nulls":1,"nullsWorthShowing":true,"reports":5,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2026},{"slug":"foselutoclax","name":"Foselutoclax","fullName":"Foselutoclax (UBX1325)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An eye shot that clears worn-out cells.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2025},{"slug":"ginsenoside-rg3","name":"Ginsenoside Rg3","fullName":"20(S)-Ginsenoside Rg3, triterpenoid saponin from Panax ginseng","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is data in people, but it only shows how the compound is absorbed and cleared after a shot into the muscle in healthy volunteers.","band":"limited","bandWhy":"1 completed trial, 24 people given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2020},{"slug":"glutathione","name":"Glutathione","fullName":"Glutathione (GSH, gamma-glutamyl-cysteinyl-glycine)","category":"Antioxidant","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The body's main antioxidant inside cells, made of three amino acids.","band":"limited","bandWhy":"1 completed trial, 54 people given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2026},{"slug":"glynac","name":"GlyNAC","fullName":"GlyNAC (Glycine + N-Acetylcysteine)","category":"Antioxidant","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A mix of glycine and NAC, two building blocks the body uses to make its main antioxidant, glutathione.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2023},{"slug":"hcg","name":"HCG","fullName":"Human Chorionic Gonadotropin","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"An FDA-approved hormone used in fertility, and to keep the testicles working in men on testosterone.","band":"limited","bandWhy":"2 completed trials, 55 people given it","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2020},{"slug":"ketone-esters","name":"Ketone esters","fullName":"Ketone monoesters, exogenous beta-hydroxybutyrate donors","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A fair number of studies, mostly on one dose before exercise.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2023},{"slug":"lamivudine","name":"Lamivudine","fullName":"Lamivudine (3TC), nucleoside reverse transcriptase inhibitor","category":"Anti-aging","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Thirty years of use in HIV and hepatitis B, with a large, well-known safety record.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2025},{"slug":"lanifibranor","name":"Lanifibranor","fullName":"Lanifibranor, pan-PPAR agonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A daily pill for fatty liver disease that works on all three PPAR switches.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"maritide","name":"MariTide","fullName":"Maridebart Cafraglutide (MariTide, AMG 133)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Amgen's once a month obesity shot.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2025},{"slug":"monlunabant","name":"Monlunabant","fullName":"Monlunabant (INV-202)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Novo Nordisk's CB1 blocker pill, built to act mostly outside the brain.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2025},{"slug":"nimacimab","name":"Nimacimab","fullName":"Nimacimab, peripherally restricted CB1 antibody","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An antibody that blocks the cannabinoid CB1 receptor outside the brain.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"nnz-2591","name":"NNZ-2591","fullName":"NNZ-2591, cyclic glycine-proline analog","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A pill that copies a natural breakdown product of IGF-1, from the makers of trofinetide (Daybue).","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"pegozafermin","name":"Pegozafermin","fullName":"Pegozafermin (BIO89-100)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A long-acting copy of FGF21, a liver hormone, given every week or two.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2024},{"slug":"plasma-dilution","name":"Plasma Dilution","fullName":"Plasma dilution (neutral blood exchange with saline and albumin)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nobody has had the neutral blood exchange described in the mouse work, and no trial of it is registered under that name.","band":"limited","bandWhy":"2 completed trials, 42 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2025},{"slug":"pterostilbene","name":"Pterostilbene","fullName":"Pterostilbene, the dimethyl ether analogue of resveratrol","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One study of 80 adults, reported in two papers, one on effects and one on safety.","band":"limited","bandWhy":"1 completed trial, 80 people given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2014},{"slug":"somatropin","name":"Somatropin","fullName":"Somatropin (recombinant human growth hormone)","category":"Growth Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Lab-made human growth hormone, the same as the one your body makes.","band":"limited","bandWhy":"2 completed trials, 84 people given it","nulls":1,"nullsWorthShowing":true,"reports":9,"reportedSideEffects":6,"isPeptide":false,"newestStudy":2012},{"slug":"tern-601","name":"TERN-601","fullName":"TERN-601, oral small-molecule GLP-1 receptor agonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Two studies in people, published together, both against a dummy pill.","band":"limited","bandWhy":"1 completed trial, 3 people given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"tesofensine","name":"Tesofensine","fullName":"Tesofensine (triple monoamine reuptake inhibitor)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An experimental weight-loss pill, not a peptide.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2012},{"slug":"trevogrumab","name":"Trevogrumab","fullName":"Trevogrumab (REGN1033) with garetosmab (REGN2477)","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Regeneron's antibody that blocks myostatin, used alone or with garetosmab, which blocks activin A.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2025},{"slug":"vitamin-b12","name":"Vitamin B12","fullName":"Vitamin B12 (Cobalamin)","category":"Metabolic","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"An essential vitamin given as a shot for a shortage.","band":"limited","bandWhy":"2 completed trials, none stating how many people","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2020},{"slug":"fisetin","name":"Fisetin","fullName":"Fisetin (senolytic flavonoid)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There are no results in people yet.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"hec88473","name":"HEC88473","fullName":"HEC88473, dual GLP-1 and FGF21 receptor agonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One first study in people, giving a single dose at rising amounts.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2025},{"slug":"inulin","name":"Inulin","fullName":"Inulin, chicory-derived fructan and soluble fibre","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A fair amount of human research on blood sugar and bowel habits.","band":"limited","bandWhy":"1 completed trial, 39 people given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2025},{"slug":"l-carnitine","name":"L-Carnitine","fullName":"L-Carnitine","category":"Muscle & Performance","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A compound your body needs to burn fat.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2018},{"slug":"l-leucine","name":"L-leucine","fullName":"L-leucine, branched-chain essential amino acid","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A fair amount of human research on body make-up in older adults.","band":"limited","bandWhy":"1 completed trial, 30 people given it","nulls":1,"nullsWorthShowing":true,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2022},{"slug":"magnesium","name":"Magnesium","fullName":"Magnesium (various salts)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Plenty of human studies for blood pressure and blood sugar, with small effects.","band":"limited","bandWhy":"1 completed trial, 46 people given it","nulls":1,"nullsWorthShowing":true,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2021},{"slug":"mitoq","name":"MitoQ","fullName":"MitoQ (mitoquinone mesylate), mitochondria-targeted antioxidant","category":"Antioxidant","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One study in healthy older adults, with a dummy pill for comparison, showed better blood vessel function.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2024},{"slug":"nad-plus","name":"NAD+","fullName":"Nicotinamide Adenine Dinucleotide","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One study in people, and it measured blood chemistry, not benefit.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2021},{"slug":"nmnh","name":"NMNH","fullName":"Reduced nicotinamide mononucleotide, dihydronicotinamide mononucleotide","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Raises NAD in cells and mouse tissue faster and higher than NMN, by a route that skips two slow enzyme steps.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2023},{"slug":"noopept","name":"Noopept","fullName":"Noopept (Omberacetam)","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A memory drug approved in Russia, built from a two amino acid piece.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2008},{"slug":"nrh","name":"NRH","fullName":"Dihydronicotinamide riboside, the reduced form of nicotinamide riboside","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"In cells grown in a dish, NRH raised NAD 2.","band":"limited","bandWhy":"1 completed trial, 65 people given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"rtr242","name":"RTR242","fullName":"RTR242, oral autophagy and lysosomal enhancer (Retro Biosciences)","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The first drug in people from Retro Biosciences, the longevity company backed by Sam Altman.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"srt2104","name":"SRT2104","fullName":"SRT2104, small-molecule SIRT1 activator","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Several early human trials against a dummy, in different groups of people, with modest results.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2013},{"slug":"testosterone-enanthate","name":"Testosterone enanthate","fullName":"Testosterone enanthate, long-chain injectable ester","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Long approved use, and it moves through the body the same way as cypionate.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"urolithin-b","name":"Urolithin B","fullName":"Urolithin B, gut microbial metabolite of ellagitannins","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Sold on the good name of urolithin A, which has human studies.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":1,"nullsWorthShowing":true,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2025},{"slug":"ursodeoxycholic-acid","name":"Ursodeoxycholic acid","fullName":"Ursodeoxycholic acid (ursodiol), bile acid and mitochondrial stabiliser","category":"Longevity","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Decades of approved use in liver diseases where bile backs up.","band":"limited","bandWhy":"1 completed trial, 30 people given it","nulls":1,"nullsWorthShowing":true,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2023},{"slug":"ursolic-acid","name":"Ursolic acid","fullName":"Ursolic acid, pentacyclic triterpenoid from apple peel","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One study in 16 men over eight weeks.","band":"limited","bandWhy":"1 completed trial, 16 people given it","nulls":1,"nullsWorthShowing":true,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2019},{"slug":"zinc-l-carnosine","name":"Zinc-L-carnosine","fullName":"Zinc-L-carnosine (polaprezinc), zinc and carnosine chelate","category":"Healing & Recovery","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A long record as an approved drug in Japan for stomach ulcers, plus a trial that assigned people by chance in lining injury from radiotherapy.","band":"limited","bandWhy":"1 completed trial, none stating how many people","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2020},{"slug":"halofuginone","name":"Halofuginone","fullName":"Halofuginone (febrifugine derivative, prolyl-tRNA synthetase inhibitor)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Very little.","band":"preliminary","bandWhy":"3 human studies where nobody was given it, 1 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"adiponectin","name":"Adiponectin","fullName":"Adiponectin (ADIPOQ)","category":"Metabolic","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No person has been given adiponectin, or a drug that switches on its receptors, in any study we could find.","band":"preliminary","bandWhy":"3 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2020},{"slug":"clusterin","name":"Clusterin","fullName":"Clusterin (apolipoprotein J, CLU)","category":"Longevity","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nobody has been given clusterin.","band":"preliminary","bandWhy":"2 human studies where nobody was given it, 1 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2021},{"slug":"gym329","name":"GYM329","fullName":"GYM329 (RO7204239), anti-latent myostatin sweeping antibody","category":"Muscle & Performance","tier":"many","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No published results in people.","band":"preliminary","bandWhy":"2 human studies where nobody was given it, 1 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"abt-737","name":"ABT-737","fullName":"ABT-737, injectable BH3 mimetic inhibitor of BCL-2, BCL-xL and BCL-w","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2024},{"slug":"acarbose","name":"Acarbose","fullName":"Acarbose (alpha-glucosidase inhibitor)","category":"Longevity","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Plenty for diabetes and blood sugar, close to none for ageing.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2019},{"slug":"alpha-ketobutyrate","name":"Alpha-ketobutyrate","fullName":"Alpha-ketobutyrate, an intermediate of the transsulfuration pathway","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No person has been given alpha-ketobutyrate in any published study that could be found.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2023},{"slug":"apitegromab","name":"Apitegromab","fullName":"Apitegromab (SRK-015)","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An antibody that blocks myostatin, a brake on muscle.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"azelaprag","name":"Azelaprag","fullName":"Azelaprag (BGE-105), oral small-molecule apelin receptor agonist","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There are two registered human studies: a mid-stage study of 204 people that was stopped, and an early study of 16 people on how the body handles the…","band":"preliminary","bandWhy":"2 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"ccl11-blockade","name":"CCL11 Blockade","fullName":"CCL11 / eotaxin-1 blockade (lowering a pro-ageing chemokine)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Observation only.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2021},{"slug":"er-100","name":"ER-100","fullName":"ER-100, partial epigenetic reprogramming gene therapy (OSK)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The first test in people of partial cell reprogramming.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"folate","name":"Folate","fullName":"Folate (folic acid and 5-MTHF)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The number moves.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2006},{"slug":"gpld1","name":"Gpld1","fullName":"Gpld1 (glycosylphosphatidylinositol-specific phospholipase D1)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Watching only, and small.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2026},{"slug":"klotho","name":"Klotho","fullName":"Alpha-Klotho (secreted s-KL) and klotho-based therapies","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nobody has given klotho to a person in a published study.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"metformin-plus-rapamycin","name":"Metformin plus rapamycin","fullName":"Metformin plus rapamycin (Interventions Testing Program combination arm)","category":"Longevity","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"None for the pair.","band":"preliminary","bandWhy":"2 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2025},{"slug":"remternetug","name":"Remternetug","fullName":"Remternetug (LY3372993)","category":"Nootropic & CNS","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Lilly's follow-up to donanemab, made to be self-injected at home.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"rls-1496","name":"RLS-1496","fullName":"RLS-1496, topical GPX4-modulating senolytic","category":"Anti-aging","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Rubedo's skin cream meant to clear worn-out skin cells.","band":"preliminary","bandWhy":"1 human study where nobody was given it, 1 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2026},{"slug":"taldefgrobep-alfa","name":"Taldefgrobep alfa","fullName":"Taldefgrobep alfa (BHV-2000)","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Biohaven's drug that blocks myostatin and activin, two brakes on muscle.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"vitamin-k2","name":"Vitamin K2","fullName":"Vitamin K2 (menaquinone, MK-7 and MK-4)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One useful bone-density trial for MK-7, plus a large food survey linking K2 to less heart disease.","band":"preliminary","bandWhy":"2 human studies where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2013},{"slug":"25-hydroxycholesterol","name":"25-Hydroxycholesterol","fullName":"25-Hydroxycholesterol (25-HC), oxysterol product of cholesterol 25-hydroxylase","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None as a treatment.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2025},{"slug":"apigenin","name":"Apigenin","fullName":"Apigenin, a flavone found in parsley, celery and chamomile","category":"Antioxidant","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One study in 11 healthy adults, measuring how much apigenin reaches the blood after eating it in food.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2018},{"slug":"atx-304","name":"ATX-304","fullName":"ATX-304 (O-304), pan-AMPK activator","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"ATX-304 is a pill that switches on AMPK, the cell's fuel sensor.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2025},{"slug":"beta-2-microglobulin","name":"Beta-2 Microglobulin","fullName":"Beta-2 microglobulin (B2M)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"From watching, and fairly large for this field.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2025},{"slug":"calcium-akg","name":"Calcium AKG","fullName":"Calcium Alpha-Ketoglutarate (Ca-AKG)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The only study in people is a look back at 42 people who already bought the pill, with no comparison group.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"cardarine","name":"Cardarine","fullName":"GW501516 (cardarine)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Cardarine is a drug GSK stopped developing, reportedly after long rodent studies found cancers in many organs.","band":"preliminary","bandWhy":"1 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":7,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2012},{"slug":"enclomiphene","name":"Enclomiphene","fullName":"Enclomiphene citrate","category":"Hormone","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Enclomiphene is one half of the fertility drug clomiphene.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2025},{"slug":"ergothioneine","name":"Ergothioneine","fullName":"L-Ergothioneine","category":"Antioxidant","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An antioxidant from food, mainly mushrooms, that your body pulls into its cells.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2020},{"slug":"fgf17","name":"FGF17","fullName":"FGF17 (fibroblast growth factor 17)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nobody has been given FGF17.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2026},{"slug":"flgr-242","name":"FLGR-242","fullName":"FLGR-242 (recombinant truncated follistatin construct)","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"FLGR-242 is a lab-made piece of follistatin, sold on the gray market since late 2025.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2017},{"slug":"gdf11","name":"GDF11","fullName":"Growth/differentiation factor 11","category":"Anti-aging","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One measuring study and no trials.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2023},{"slug":"iron","name":"Iron","fullName":"Iron (ferrous salts and hidden multi iron)","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The human evidence this page needs is about harm from high ferritin, and how doctors check for it.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2012},{"slug":"lotiglipron","name":"Lotiglipron","fullName":"Lotiglipron (PF-07081532), oral small-molecule GLP-1 receptor agonist","category":"Metabolic","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One large study that clearly worked for both diabetes and obesity, and was stopped early for safety before it could finish.","band":"preliminary","bandWhy":"1 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2025},{"slug":"metreleptin","name":"Metreleptin","fullName":"Metreleptin (Myalept), recombinant human leptin analogue","category":"Hormone","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"An approved drug for a rare disease.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2022},{"slug":"osk-partial-reprogramming","name":"OSK Partial Reprogramming","fullName":"OSK partial reprogramming (transient expression of Oct4, Sox2 and Klf4)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nobody has had OSK given to their whole body.","band":"preliminary","bandWhy":"1 registered with no result","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2026},{"slug":"oxandrolone","name":"Oxandrolone","fullName":"Oxandrolone, oral 17-alpha-alkylated anabolic androgen","category":"Muscle & Performance","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"A strong set of results in people with a serious disease, followed for years, measuring bones and growth.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2016},{"slug":"rilmenidine","name":"Rilmenidine","fullName":"Rilmenidine (I1-imidazoline receptor agonist antihypertensive)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Many years of use as a blood pressure pill where it is sold.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2023},{"slug":"skq1","name":"SkQ1","fullName":"SkQ1 (plastoquinonyl decyltriphenylphosphonium, Visomitin)","category":"Antioxidant","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"SkQ1 is an antioxidant aimed at mitochondria, the cell's power plants.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2016},{"slug":"stanozolol","name":"Stanozolol","fullName":"Stanozolol, 17-alpha-alkylated anabolic androgen","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"One real medical use with long-term safety data, in a rare disease, working in a way that has nothing to do with muscle.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2007},{"slug":"timp2","name":"TIMP2","fullName":"TIMP2 (tissue inhibitor of metalloproteinases 2)","category":"Longevity","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Nobody has been given TIMP2 as a treatment.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2023},{"slug":"verteporfin","name":"Verteporfin","fullName":"Verteporfin (Visudyne), YAP inhibitor","category":"Healing & Recovery","tier":"few","usLegal":"approved","usLabel":"Approved","humanLine":"Verteporfin is an approved eye drug.","band":"preliminary","bandWhy":"1 human study where nobody was given it","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"17-alpha-estradiol","name":"17-alpha-estradiol","fullName":"17-alpha-estradiol, non-feminising estradiol stereoisomer","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for ageing.","band":"preclinical","bandWhy":"4 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2021},{"slug":"5-amino-1mq","name":"5-Amino-1MQ","fullName":"5-Amino-1-Methylquinolinium (NNMT inhibitor)","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An experimental small molecule that blocks an enzyme linked to fat storage.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2018},{"slug":"anti-il-11","name":"Anti-IL-11","fullName":"Interleukin-11 signalling inhibition (anti-IL-11 antibody)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for ageing.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2024},{"slug":"astaxanthin","name":"Astaxanthin","fullName":"Astaxanthin, marine carotenoid","category":"Antioxidant","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"It is widely sold, and many studies in people look at blood markers and short-term results.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2026},{"slug":"bam15","name":"BAM15","fullName":"BAM15, mitochondrial uncoupler","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"BAM15 makes cells burn fuel as heat.","band":"preclinical","bandWhy":"3 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2024},{"slug":"cape","name":"Caffeic acid phenethyl ester","fullName":"Caffeic acid phenethyl ester (CAPE, propolis constituent)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None.","band":"preclinical","bandWhy":"4 animal studies, 2 lab studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2024},{"slug":"chemical-reprogramming","name":"Chemical Reprogramming Cocktails","fullName":"Chemical reprogramming cocktails (small-molecule induced pluripotency and partial reprogramming)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None.","band":"preclinical","bandWhy":"1 animal study, 3 lab studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2025},{"slug":"cms-121","name":"CMS-121","fullName":"CMS-121, fisetin derivative","category":"Nootropic & CNS","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"CMS-121 is a lab-made cousin of fisetin, from the Salk Institute.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2024},{"slug":"e5-plasma-fraction","name":"E5 Plasma Fraction","fullName":"E5 (purified plasma fraction from young pigs)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None.","band":"preclinical","bandWhy":"4 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2024},{"slug":"gw0742","name":"GW0742","fullName":"GW0742, selective PPAR-beta/delta agonist","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The sibling of GW501516 (cardarine), sold on the same endurance story with none of the same evidence.","band":"preclinical","bandWhy":"3 animal studies, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":3,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2019},{"slug":"isrib","name":"ISRIB","fullName":"ISRIB, integrated stress response inhibitor","category":"Anti-aging","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"ISRIB is not an approved medicine anywhere.","band":"preclinical","bandWhy":"3 animal studies, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2020},{"slug":"loy-002","name":"LOY-002","fullName":"LOY-002, canine lifespan-extension drug (Loyal)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A daily pill for older dogs that could become the first drug the FDA approves to extend lifespan.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"meclizine","name":"Meclizine","fullName":"Meclizine, antihistamine and motion sickness drug","category":"Longevity","tier":"zero","usLegal":"approved","usLabel":"Approved","humanLine":"A long record as a travel sickness and dizziness pill you can buy over the counter.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2026},{"slug":"ndga","name":"NDGA","fullName":"Nordihydroguaiaretic acid, lignan from creosote bush","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"No ageing data in people.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2016},{"slug":"o-vanillin","name":"o-Vanillin","fullName":"o-Vanillin (2-hydroxy-3-methoxybenzaldehyde), a natural senolytic aldehyde","category":"Anti-aging","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A natural cousin of vanillin, the vanilla smell chemical.","band":"preclinical","bandWhy":"1 animal study, 3 lab studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2025},{"slug":"oskm-cyclic-partial-reprogramming","name":"OSKM Cyclic Partial Reprogramming","fullName":"OSKM cyclic partial reprogramming (short cycles of Oct4, Sox2, Klf4 and c-Myc)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None.","band":"preclinical","bandWhy":"6 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2024},{"slug":"piperlongumine","name":"Piperlongumine","fullName":"Piperlongumine (piplartine), alkaloid amide from Piper longum","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None found.","band":"preclinical","bandWhy":"1 animal study, 3 lab studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"platelet-factor-4","name":"Platelet Factor 4","fullName":"Platelet factor 4 (CXCL4)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None as a treatment.","band":"preclinical","bandWhy":"3 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2023},{"slug":"procyanidin-c1","name":"Procyanidin C1","fullName":"Procyanidin C1 (PCC1), trimeric proanthocyanidin from grape seed","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"protandim","name":"Protandim","fullName":"Protandim, botanical Nrf2-activating mixture","category":"Antioxidant","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None for ageing.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2016},{"slug":"rapamycin-plus-acarbose","name":"Rapamycin plus acarbose","fullName":"Rapamycin plus acarbose (Interventions Testing Program combination arm, RaAc)","category":"Longevity","tier":"zero","usLegal":"approved","usLabel":"Approved","humanLine":"None.","band":"preclinical","bandWhy":"7 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":5,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2023},{"slug":"senolytic-car-t","name":"Senolytic CAR T cells","fullName":"Senolytic chimeric antigen receptor T cells directed at uPAR","category":"Immune","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Living immune cells, called T cells, engineered to find and kill worn-out 'zombie' cells by a marker on their surface called uPAR.","band":"preclinical","bandWhy":"3 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2024},{"slug":"senolytic-vaccine-gpnmb","name":"Senolytic vaccine (anti-GPNMB)","fullName":"Senolytic vaccination against glycoprotein nonmetastatic melanoma protein B (GPNMB)","category":"Immune","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A vaccine that trains the immune system to attack GPNMB, a protein found in high amounts on worn-out 'zombie' cells.","band":"preclinical","bandWhy":"3 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2025},{"slug":"sg1002","name":"SG1002","fullName":"SG1002, oral hydrogen sulfide prodrug","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Early work in people with heart failure.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2024},{"slug":"slu-pp-332","name":"SLU-PP-332","fullName":"SLU-PP-332 (ERR agonist exercise mimetic)","category":"Muscle & Performance","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"An experimental compound sold as exercise in a pill.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":8,"reportedSideEffects":5,"isPeptide":false,"newestStudy":2024},{"slug":"sr9009","name":"SR9009","fullName":"SR9009 (stenabolic)","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"SR9009 is sold as exercise in a pill.","band":"preclinical","bandWhy":"1 animal study, 1 lab study, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2018},{"slug":"srk-439","name":"SRK-439","fullName":"SRK-439, subcutaneous selective myostatin inhibitor","category":"Muscle & Performance","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Scholar Rock's follow-up to apitegromab, built to be self-injected alongside GLP-1 drugs.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2026},{"slug":"trigonelline","name":"Trigonelline","fullName":"Trigonelline (coffee and fenugreek alkaloid)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Trigonelline is a natural compound in coffee and fenugreek that the body can turn into NAD+.","band":"preclinical","bandWhy":"1 animal study, no human study","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2026},{"slug":"trodusquemine","name":"Trodusquemine","fullName":"Trodusquemine (MSI-1436)","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"Trodusquemine is a compound first found in dogfish sharks.","band":"preclinical","bandWhy":"2 animal studies, no human study","nulls":0,"nullsWorthShowing":false,"reports":4,"reportedSideEffects":3,"isPeptide":false,"newestStudy":2017},{"slug":"turkesterone","name":"Turkesterone","fullName":"Turkesterone, ecdysteroid from Ajuga turkestanica","category":"Muscle & Performance","tier":"few","usLegal":"notapproved","usLabel":"Not approved","humanLine":"None.","band":"none","bandWhy":"no study cited on this page yet","nulls":0,"nullsWorthShowing":false,"reports":6,"reportedSideEffects":4,"isPeptide":false,"newestStudy":2024},{"slug":"bergamot","name":"Bergamot","fullName":"Citrus bergamia polyphenol extract","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"A small set of human studies reports strikingly big changes in blood fats.","band":"none","bandWhy":"no study cited on this page yet","nulls":0,"nullsWorthShowing":false,"reports":0,"reportedSideEffects":0,"isPeptide":false,"newestStudy":2022},{"slug":"electrolytes","name":"Electrolytes","fullName":"Electrolytes (sodium, potassium, magnesium education)","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"This page explains a blood test.","band":"none","bandWhy":"no study cited on this page yet","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2017},{"slug":"melatonin","name":"Melatonin","fullName":"Melatonin (N-acetyl-5-methoxytryptamine)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"There is evidence of a small effect on sleep.","band":"none","bandWhy":"no study cited on this page yet","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2013},{"slug":"psyllium","name":"Psyllium","fullName":"Psyllium (Plantago ovata husk)","category":"Metabolic","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The evidence that it lowers cholesterol, as an add-on to diet, is real and old.","band":"none","bandWhy":"no study cited on this page yet","nulls":0,"nullsWorthShowing":false,"reports":2,"reportedSideEffects":2,"isPeptide":false,"newestStudy":2000},{"slug":"zinc","name":"Zinc","fullName":"Zinc (elemental zinc salts)","category":"Longevity","tier":"zero","usLegal":"notapproved","usLabel":"Not approved","humanLine":"The human evidence that matters is about zinc shortage and fixing it.","band":"none","bandWhy":"no study cited on this page yet","nulls":0,"nullsWorthShowing":false,"reports":1,"reportedSideEffects":1,"isPeptide":false,"newestStudy":2014}]