Legal status · United States
Is Angiotensin II legal in the United States?
Written by Aaron CuhaReviewed Sep 2026
Direct answer
Yes. Angiotensin II is an approved medicine in the United States. Its legal category is "FDA-approved, prescription only". The approval covers the use on its label. It is given out on prescription, not sold over the counter. Products labeled "research use only" are not covered by that approval, and that label does not make them legal to use in people. On the evidence, 1 completed human trial is cited on its profile.
- People given it
- 344
- Found nothing
- 0
Legal category
FDA-approved, prescription only
GIAPREZA, NDA 209360, approved 21 December 2017. When we checked the FDA drug database (Drugs@FDA) on 11 September 2026, two forms were listed as Prescription and one as Discontinued. A generic was approved in June 2025.
Reviewed Sep 2026. This is a legal category, not legal advice.
A "research use only" label on a vial does not make it legal to use on people.
Angiotensin II in the United States at a glance
| Legal category | FDA-approved, prescription only |
|---|---|
| Note | GIAPREZA, NDA 209360, approved 21 December 2017. When we checked the FDA drug database (Drugs@FDA) on 11 September 2026, two forms were listed as Prescription and one as Discontinued. A generic was approved in June 2025. |
| FDA approval status | FDA approved 21 December 2017 (GIAPREZA, NDA 209360) to raise blood pressure in adults in shock from a severe infection (septic shock) or other shock where the blood vessels open too wide. Prescription only, given by drip into a vein. A generic angiotensin II acetate injection was approved 3 June 2025 (ANDA 216966). |
| Studies in people | 5 of 6 sources on the profile |
| Reviewed | Sep 2026 |
The legal category and note come from the Angiotensin II profile. We checked them against U.S. Food and Drug Administration (FDA) listings on the reviewed date.
What this means
- 01
FDA has approved Angiotensin II for at least one use named on its label. So a proper pharmacy-grade product exists in the United States, and pharmacies hand it out on prescription.
- 02
Approval covers only the uses named on the label. Any other use is a prescriber's call. The approval itself does not cover it.
- 03
Unlicensed vials sold online, including those labeled "research use only", are not the approved product. The approval does not cover them.
What Angiotensin II is
Angiotensin II is the body's main hormone for raising blood pressure. It is approved as a drip for shock, when blood pressure will not hold even on standard drugs. In the main study of 344 people, it raised blood pressure. By day 28, 46 percent on the drug had died, against 54 percent on a dummy drip. That gap was too small to rule out chance.
Angiotensin II is a small hormone, 8 building blocks long. The body cuts it from a bigger protein in two steps, using renin and then ACE.
How it works: In people, angiotensin II docks on the AT1 receptor on blood vessel muscle and squeezes the vessels. It also docks on the adrenal glands and releases aldosterone, which makes the body hold on to salt and water.
Approval history: FDA approved 21 December 2017 (GIAPREZA, NDA 209360) to raise blood pressure in adults in shock from a severe infection (septic shock) or other shock where the blood vessels open too wide. Prescription only, given by drip into a vein. A generic angiotensin II acetate injection was approved 3 June 2025 (ANDA 216966).
How FDA treats this kind of product
Approves prescription drugs, each for a named use. It also acts against unapproved products, including peptides sold online. Compounding pharmacies, which mix drugs to order, may make some compounds with a prescription. That only applies when the FDA puts the compound in a category of bulk ingredients it allows.
The legal category above is how The Longevity Archive reads U.S. Food and Drug Administration listings for Angiotensin II on the reviewed date. It is not a legal opinion. Rules change. Bringing a compound into the country, prescribing it and owning it can each be treated differently. Check with the agency before you act on anything here.
Angiotensin II in sport and the military
Whether Angiotensin II is banned in sport is set by the World Anti-Doping Code and by military rules, not by its legal status in the United States. Before you compete or get tested, look up Angiotensin II by name on the Prohibited List, or look up a named product in Global DRO. Under the World Anti-Doping Code, category S0 bans, at all times, any drug-like substance that meets two tests. No other section of the List covers it. And no government health regulator anywhere has a current approval for it as a treatment in people. Many substances that are approved somewhere are banned by name in another section. So approval does not mean a substance is allowed in sport.
- WADA Prohibited List
- Global DRO (check a named product)
- USADA (US athletes)
- Operation Supplement Safety (US service members)
The rules you compete or serve under decide this, not this page.
Angiotensin II in other countries
United Kingdom
Prescription routePrescription only; check current MHRA status
Is Angiotensin II legal in the United Kingdom?Australia
Prescription routePrescription only; check current TGA status
Is Angiotensin II legal in Australia?Canada
Prescription routePrescription only; check current Health Canada status
Is Angiotensin II legal in Canada?Frequently asked questions
Is Angiotensin II legal in the United States?
Yes. Angiotensin II is an approved medicine in the United States. Its legal category is "FDA-approved, prescription only". The approval covers the use on its label. It is given out on prescription, not sold over the counter. Products labeled "research use only" are not covered by that approval, and that label does not make them legal to use in people. On the evidence, 1 completed human trial is cited on its profile. Note: GIAPREZA, NDA 209360, approved 21 December 2017. When we checked the FDA drug database (Drugs@FDA) on 11 September 2026, two forms were listed as Prescription and one as Discontinued. A generic was approved in June 2025.
Can I buy Angiotensin II in the United States?
Only with a prescription. In the United States, Angiotensin II has the legal category "FDA-approved, prescription only". Pharmacies hand it out with a prescription, for the use it is approved for. Buying it from unlicensed sellers online, or as a "research chemical", is outside that system. You get none of the protection the regulator gives. Note: GIAPREZA, NDA 209360, approved 21 December 2017. When we checked the FDA drug database (Drugs@FDA) on 11 September 2026, two forms were listed as Prescription and one as Discontinued. A generic was approved in June 2025.
Is Angiotensin II FDA approved?
Yes. FDA status: FDA approved 21 December 2017 (GIAPREZA, NDA 209360) to raise blood pressure in adults in shock from a severe infection (septic shock) or other shock where the blood vessels open too wide. Prescription only, given by drip into a vein. A generic angiotensin II acetate injection was approved 3 June 2025 (ANDA 216966).. Current US legal category: "FDA-approved, prescription only". On the evidence, 1 completed human trial is cited on its profile.
Related compounds in the United States
Full research profile
How Angiotensin II works, the studies we cite, FDA status and the full legal summary are all on its compound profile.
Angiotensin II profileThis page is general information about the legal status of Angiotensin II in the United States, current as of Sep 2026. It is not legal advice. Legal status changes. For your own situation, check with U.S. Food and Drug Administration or ask a lawyer. Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use. Sellers named on the price pages are ranked by certificate tier, then price, and any affiliate income is disclosed there. Naming a seller is not a recommendation to buy or use anything.