Reference · 190 compounds
Half-Life Reference
How long each compound stays active, placed on a single scale from minutes to weeks. Half-life is the time for the amount in the body to fall by half; after roughly four to five half-lives, a compound has essentially cleared.
Ultra-short · MinutesShort · 1–6 hoursMedium · 6–24 hoursLong · 1–7 daysVery long · Weeks+
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5 min1 hr1 day1 wk1 mo
- ThymopentinImmuneVery short (~30 seconds native)
- GLP-1Metabolic~1-2 minutes (native)
- VIPHealing & Recovery~1-2 minutes (native)
- SomatostatinGrowth Hormone~1-3 minutes (native)
- GonadorelinHormone~2-4 minutes
- OxytocinHormone~1-6 minutes
- GLP-2Metabolic~7 minutes (native)
- GlucagonMetabolic~8-18 minutes
- SermorelinGrowth Hormone~10-20 minutes
- VasopressinHormone~10-20 minutes
- SemaxNootropic & CNSShort (minutes); intranasal use
- SelankNootropic & CNSShort (minutes); intranasal use
- EpitalonAnti-agingShort (minutes)
- GlutathioneAntioxidantMinutes (plasma)
- Melanotan IMelanocortin~30 minutes (implant provides sustained release)
- Kisspeptin-10HormoneShort (minutes)
- GhrelinGrowth Hormone~30 minutes
- DSIPNootropic & CNSShort (minutes)
- Alpha-MSHMelanocortinShort (minutes)
- Alpha-Lipoic AcidAntioxidant~30 minutes
- MGFMuscle & PerformanceMinutes (native peptide)
- IGF-1 DESMuscle & PerformanceMinutes
- Ac-SDKPHealing & RecoveryMinutes (ACE cleavage)
- TesamorelinGrowth Hormone~26-38 minutes
- GHRP-6Growth Hormone~15-60 minutes
- GHRP-2Growth Hormone~30-60 minutes
- PramlintideMetabolic~48 minutes
- HexarelinGrowth Hormone~55 minutes
- GHK-CuHealing & RecoveryShort (topical use)
- ThymalinImmuneShort
- Melanotan IIMelanocortin~1 hour
- FOXO4-DRIAnti-agingShort
- NAD+LongevityShort
- NMNLongevityShort
- MOTS-cLongevityShort
- HumaninLongevityShort
- GDF-11LongevityShort
- AOD-9604MetabolicShort
- HGH Fragment 176-191MetabolicShort
- AdipotideMetabolicShort
- FollistatinMuscle & PerformanceShort (protein)
- ARA-290Healing & RecoveryShort
- KPVHealing & RecoveryShort
- LarazotideHealing & RecoveryShort (acts locally in the gut)
- LL-37ImmuneShort
- DihexaNootropic & CNSShort
- P21Nootropic & CNSShort
- PE-22-28Nootropic & CNSShort
- NoopeptNootropic & CNSShort
- GHRP-1Growth HormoneShort
- 5-Amino-1MQMetabolicShort
- DavunetideNootropic & CNSShort
- FGLNootropic & CNSShort
- PinealonNootropic & CNSShort
- ThymogenImmuneShort
- ThymulinImmuneShort
- VilonAnti-agingShort
- CardiogenAnti-agingShort
- TeriparatideHormone~1 hour
- AbaloparatideHormone~1 hour
- CalcitoninHormone~1 hour
- ArgirelineCosmeticTopical (surface)
- MatrixylCosmeticTopical (penetrates surface)
- SNAP-8CosmeticTopical (surface)
- DanuglipronMetabolicShort (was studied as daily dosing)
- Nicotinamide RibosideLongevityShort
- SpermidineLongevityShort
- Calcium AKGLongevityShort
- GlyNACLongevityShort (both components)
- SLU-PP-332LongevityShort
- RLS-1496Anti-agingTopical application
- BRPMetabolicShort; no human pharmacokinetics
- PTD-DBMCosmeticNot established (topical)
- BAM15MetabolicShort in rodents; unknown in humans
- AICARMuscle & PerformanceShort
- SR9009MetabolicShort; poor oral bioavailability
- AHK-CuCosmeticNot established (topical)
- B7-33Healing & RecoveryShort
- Orexin-ANootropic & CNSShort
- OctreotideHormone~1.7 hours (long-acting depot lasts weeks)
- IpamorelinGrowth Hormone~2 hours
- Thymosin Alpha-1Immune~2 hours
- Thymosin Beta-4Healing & Recovery~2 hours
- TeduglutideMetabolic~2 hours
- FisetinLongevity~1-3 hours
- ExenatideMetabolic~2.4 hours (immediate release)
- ElamipretideAnti-aging~2-3 hours
- DesmopressinHormone~1.5-3.5 hours
- PT-141Melanocortin~2.7 hours
- LixisenatideMetabolic~3 hours
- LeuprolideHormone~3 hours (depot lasts months)
- Urolithin ALongevitySeveral hours
- VerteporfinHealing & RecoveryHours
- SomatropinGrowth Hormone~3-4 hours (subcutaneous)
- BPC-157Healing & Recovery~4 hours
- GoserelinHormone~4 hours (implant lasts 1-3 months)
- DasatinibLongevity~3-5 hours
- NACAntioxidant~5-6 hours
- Methylene BlueAntioxidant~5 to 6 hours (oral)
- TB-500Healing & Recovery~6 hours
- SetmelanotideMelanocortin~11 hours
- LiraglutideMetabolic~13 hours
- L-CarnitineMuscle & Performance~15 hours
- QuercetinLongevity~11-28 hours
- MK-677Growth Hormone~24 hours
- ACE-031Muscle & PerformanceDays (fusion protein)
- Vitamin B12MetabolicDays to weeks (stored in liver)
- EnobosarmMuscle & Performance~24 hours (once-daily oral)
- CardarineMetabolic~24 hours (reported)
- IGF-1 LR3Growth Hormone~20-30 hours
- HCGHormone~24-36 hours
- CetrorelixHormone~5-63 hours (formulation dependent)
- OrforglipronMetabolic~29-49 hours
- RapamycinLongevity~60 hours
- TirzepatideMetabolic~5 days
- DulaglutideMetabolic~5 days
- EfpeglenatideMetabolic~5-6 days
- RetatrutideMetabolic~6 days
- SurvodutideMetabolic~6 days
- MazdutideMetabolic~5-7 days
- SemaglutideMetabolic~7 days
- CJC-1295Growth Hormone~6-8 days (DAC version)
- CagrilintideMetabolic~7 days
- ErgothioneineAntioxidantLong (retained in tissues)
- CagriSemaMetabolic~7 days (weekly dosing)
- EcnoglutideMetabolicLong-acting
- EfocipegtrutideMetabolicLong-acting
- TesofensineMetabolic~8 days
- MariTideMetabolicWeeks (monthly dosing)
- VK2735MetabolicSupports weekly dosing (injectable)
- AmycretinMetabolicSupports weekly (injectable) dosing
- PetrelintideMetabolicSupports weekly dosing
- PemvidutideMetabolicSupports weekly dosing
- BimagrumabMetabolicWeeks (antibody)
- EloralintideMetabolicWeekly dosing (long-acting)
- RibupatideMetabolicWeekly dosing (long-acting)
- EnicepatideMetabolicWeekly dosing (long-acting)
- UBT251MetabolicWeekly dosing (long-acting)
- AZD6234MetabolicWeekly dosing
- NimacimabMetabolicWeekly dosing (antibody)
- Taldefgrobep alfaMuscle & PerformanceWeekly or monthly subcutaneous dosing
- EfruxiferminMetabolicWeekly subcutaneous dosing
- PegozaferminMetabolicWeekly or every-two-week dosing
- NavepegritideHormoneWeekly dosing (prodrug release)
- BerobenatideMetabolic~15 days (~360 hours)
- MET-233iMetabolic~19 days
- ApitegromabMuscle & PerformanceDosed every 4 weeks (IV)
- Efimosfermin alfaMetabolicOnce-monthly dosing
- FoselutoclaxLongevityIntravitreal injection; effect measured over months
- TrontinemabNootropic & CNSIV monthly for 6 months, then every 3 months
- AleniglipronMetabolicvariesOnce-daily oral dosing
- ATX-304MetabolicvariesNot published
- BGE-102LongevityvariesOnce-daily oral dosing
- BI 3034701MetabolicvariesNot disclosed
- BronchogenImmunevariesNot established
- BuntanetapNootropic & CNSvariesOnce-daily oral dosing
- CerebrolysinNootropic & CNSvariesVaries by fraction
- ChonlutenImmunevariesNot established
- CMS-121Nootropic & CNSvariesNot published
- CortagenNootropic & CNSvariesNot established
- CortexinNootropic & CNSvariesVaries (mixture)
- DersimelagonMelanocortinvariesOnce-daily oral dosing
- ElecoglipronMetabolicvariesOnce-daily oral dosing
- EnclomipheneHormonevariesOnce-daily oral dosing
- ER-100LongevityvariesSingle injection; expression controlled by doxycycline course
- FLGR-242Muscle & PerformancevariesUnknown (no published pharmacokinetics)
- GB-115Nootropic & CNSvariesNot published
- GLOW blendCosmeticvariesNot defined for the blend
- HRS-7535MetabolicvariesOnce-daily oral dosing
- KlothoLongevityvariesEndogenous protein; therapeutic forms not yet defined in humans
- KLOW blendHealing & RecoveryvariesNot defined for the blend; components differ
- LanifibranorMetabolicvariesOnce-daily oral dosing
- LivagenLongevityvariesNot established
- LorecivivintHealing & RecoveryvariesOne to two intra-articular injections per year
- LOY-002LongevityvariesOnce-daily oral dosing
- MonlunabantMetabolicvariesOnce-daily oral dosing
- N-Acetyl Semax AmidateNootropic & CNSvariesNot established
- NNZ-2591Nootropic & CNSvariesOral, twice daily
- PancragenMetabolicvariesNot established
- PEG-MGFMuscle & PerformancevariesExtended by pegylation
- Pentadeca ArginateHealing & RecoveryvariesNo human pharmacokinetics for either salt form
- PL8177MelanocortinvariesOral, gut-targeted
- PNC-27ImmunevariesNot established
- RemternetugNootropic & CNSvariesSubcutaneous dosing; interval per protocol
- RTR242Nootropic & CNSvariesOral; not disclosed
- SkQ1AntioxidantvariesNot established systemically
- SRK-439Muscle & PerformancevariesSubcutaneous; interval not disclosed
- TrevogrumabMuscle & PerformancevariesAntibody dosing per trial protocol
- TrigonellineLongevityvariesNot established
- TrodusquemineLongevityvariesNot established
Frequently asked questions
What is a peptide's half-life?
Half-life is the time it takes for the amount of a compound in the body to fall by half. After about four to five half-lives, roughly 94 to 97 percent has cleared, so half-life is a useful guide to how long a compound stays active.
Why do half-lives matter?
Half-life shapes how a compound behaves over time. Very short half-lives mean rapid clearance, while long half-lives mean the compound lingers for days. This is educational information about pharmacology, not dosing guidance.
Are these half-lives exact?
No. Half-lives vary by formulation, route, and individual, and some values are approximate or reported as ranges. The figures here reflect published values and are rounded for comparison.
Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive does not provide dosing guidance.