SR9009 dosage and evidence
Written by Aaron CuhaReviewed Sep 2026
The short answer
SR9009 is sold as exercise in a pill. It targets REV-ERB, part of the body clock. No human study has ever been published. Very little of a swallowed dose gets into the blood, and later work doubts it even works through REV-ERB.
Evidence grade for SR9009: Animal or lab only. The rule: only animal or lab studies on this page. No study in people yet. The sum on this page: 1 animal study, 1 lab study, no human study. A grade counts how much has been done to people, not whether it works.
- People given it
- 0
- Human studies
- 0
- Found nothing
- 0
Dose
No human dose established
No published study on this page has given this compound to people and reported a result.
1 animal study, 1 lab study, no human study
4 effects reported, 3 unwanted, 1 wanted, by people using it, not a trial
In plain English
In plain English, from Aaron
This is how I would explain it to a friend. The evidence, with the numbers, is further down the page.
SR9009 is sold as exercise in a pill. It is meant to act on the body clock. Almost none of a swallowed dose gets into your blood. And later lab work doubts it even works the way the label says.
What people take it for
- Endurance.
- Fat loss.
What studies in people showed
No human study has ever been published. In a 2012 mouse paper, it changed metabolism and cut fat. Very little of a swallowed dose is absorbed, and it does not last long. In 2018, a lab found some of its effects still happened in cells that lacked its target.
What people report
Reports, not study results
The good
- A few say they noticed effects, some only with an injectable version.
The bad
- Many report nothing at all, for endurance or fat loss.
- Almost none of a swallowed dose is absorbed.
- Side effect reports are thin, most likely because few people got much into their blood, not because it is safe.
Where these come from: Forum patterns from EliteFitness, MESO-Rx and LongeCity, as summed up on this page. Those are self-reports. The lab findings come from the mouse and cell studies on this page.
My bottom line
It is barely absorbed and may not work the way it claims, even in a dish. Save your money.
An opinion, not a finding. I am a coach, not a doctor.
What it has been measured to do
What people using it report
Real people telling you what happened to them. Nobody checked it, and the people who post are not a fair sample, so it cannot prove anything works. It is still the best guide on this page to what people actually do with SR9009, what they expect, and what goes wrong. The full account, including the negative reports, is below.
Nothing indexed yet
The 2 citations on this page do not report a result for any of the 36 goals indexed here. Most of what sits here is something else: a listing of a planned study, a study of how the body handles the drug, a safety report or a government record. None of those tests whether it works.
Show full evidence
What is SR9009?
SR9009 is sold as exercise in a pill. It targets REV-ERB, part of the body clock. No human study has ever been published. Very little of a swallowed dose gets into the blood, and later work doubts it even works through REV-ERB.
SR9009 acts on REV-ERB, a body clock switch. In a 2012 paper it changed metabolism and cut fat in mice. It has no human trials, and two later findings undercut the sales pitch. Very little of a swallowed dose is absorbed, and it does not last long. More important, a 2018 study found some of its effects still happened in cells with no REV-ERB at all. So the way the label says it works may not be how it works. It is not approved, and nothing published supports the claimed benefits in people.
How does SR9009 work?
It is meant to switch on REV-ERB, which ties metabolism to the body clock. Whether that is really how it works is disputed.
What do people who took SR9009 report?
This is what real people say happened to them, good and bad. Nobody measured it. A report cannot tell a real effect from the lift people get just from expecting it to work, from a diet or training change made at the same time, or from what was really in the vial. We still put it near the top. It is the next best thing to a study in people: what happens when real people use it, including what goes wrong.
- How much of it the body actually absorbs is the central argument. The recurring claim is that very little survives oral use and that the duration of action is short, and that is the explanation people offer for the split in reported outcomes.
- Doses described are around 20 to 30 mg a day, sometimes taken an hour or two before training, sometimes spread across several administrations on the theory that the short half life demands it. No schedule is agreed on in these threads.
- Reports of nothing at all are common and explicit, including from people who ran it for a stretch and saw no change in endurance and no change in fat loss.
- An injectable version is described by some as producing something where the oral had not, which is the usual way the no-effect reports get explained away. Others state that they did notice effects orally, so the explanation is contested rather than settled.
- The most consistent advice from experienced posters is to use GW-501516 instead, which is a striking pattern given that neither compound has human trial support behind it.
- Discussion of side effects is thin to absent. In something this widely described as doing nothing, that absence more likely reflects limited real exposure than safety.
Sources: EliteFitness dosing and experience threads, MESO-Rx discussion read through site-restricted search results, and a LongeCity thread on an adverse reaction, September 2026. Nothing above is attributed to any specific post and no post is reproduced.
The evidence, in charts
Fig. 1a · how many people
0people have taken this in any study cited here
0 people · 0 studies in people
What this page cites instead is 1 animal study and 1 lab study in a dish. None of them gave the compound to a person.
Counted from the list of sources on this page. We draw this chart only when a study in people is cited. An empty one is the answer, not a gap in the page.
Fig. 1b · evidence mix
None of the 2 sources here are studies in people.
- Animal study · done in animals150%
- Lab (cells in a dish) · cells or tissue150%
Counted from the list of sources on this page. It counts only what we cite, so there may be more studies out there. A review counts once, however many studies it sums up.
Fig. 2 · evidence over time
Sources here come from just two years, 2012 and 2018.
Too few different years on this page to draw a timeline. The newest source on file is from 2018, more than five years ago. Research on it may have gone quiet.
Fig. 3 · legal status at a glance
US
Not approved
UK
Not approved
AU
Not approved
CA
Not approved
Not approved in any of the four countries shown. This is what the law says, not a verdict on the science. See Legal status below for the full text and any notes.
Fig. 4 · how much does what
Nobody has tested different amounts in people
This chart would show how the effect changes as the amount goes up. For this compound, nobody has measured that in people. So we leave it empty. We will not borrow an animal chart and pretend it works the same in people.
Fig. 5 · what the molecule is
- Kind of compound
- Small molecule
- Molecule weight
- 437.9 Da
- Half-life
- Stated in words, not a numbersee the exact wording below
- Chain length
- None on file
No amino acid sequence is on file for SR9009, which is expected: a small molecule is not built from amino acids.
The studies we cite
- Animal study2012Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
In mice. It changed their metabolism.
Metabolic effects in mice.
- Lab (cells in a dish)2018SR9009 effects independent of REV-ERB
In a dish. Its effects still showed up in cells with no REV-ERB.
Effects persisted in REV-ERB-deficient cells.
Where to buy SR9009
1 seller lists SR9009 in our latest read. They are ranked by trust score, then by archive rating, then by certificate tier, then by the lowest price per milligram. Archive evidence is counted before source-backed. Each path is out of 4, and the two are not added. A higher price does not raise the score. The letter is the certificate chip. 0 of them have a published certificate that names SR9009.
Some seller links may pay this site when you buy through them. A payment never changes a seller's tier or rank, and no seller has a say in any page.
| Seller | Trust score | Vial sizes | From, per mg | Certificate for SR9009 | Seller link |
|---|---|---|---|---|---|
| Behemoth Labz | 49 WeakSource-backed 3 of 4. Archive evidence 1 of 4.B | 64 mg | $1.84 | None found for SR9009 | View |
- LC Lab-confirmed: the issuing laboratory echoed this certificate back
- A Current certificate, independent laboratory named, laboratory not yet checked
- B Certificate published, but no laboratory link, older than a year, or the laboratory did not recognise the published lookup
- C No certificate could be read
Every listing and vial size for SR9009 · How the trust score is counted
Sellers named on the price pages are ranked by certificate tier, then price, and any affiliate income is disclosed there. Naming a seller is not a recommendation to buy or use anything.
Common questions
Has SR9009 been tested in people?
Not in any study cited here. SR9009 is sold as exercise in a pill. It targets REV-ERB, part of the body clock. No human study has ever been published. Very little of a swallowed dose gets into the blood, and later work doubts it even works through REV-ERB.
What is the SR9009 dosage?
No human dose established. No published study on this page has given this compound to people and reported a result. 1 animal study, 1 lab study, no human study
Is SR9009 FDA-approved?
Not approved
Does oral SR9009 work?
Very little of a swallowed dose is absorbed, and it does not last long. No human study supports the claimed benefits.