The Longevity Archive
All compounds

Growth Hormone

13 evidence-rated growth hormone compounds.

Ipamorelin

Ipamorelin Acetate

Moderate

A selective growth hormone secretagogue and ghrelin receptor agonist that stimulates pulsatile GH release with minimal effect on cortisol or prolactin.

Growth HormoneRev. Sep 2026

CJC-1295

CJC-1295 (GHRH analogue)

Moderate

A modified GHRH analogue engineered for an extended half-life, promoting sustained growth hormone and IGF-1 release.

Growth HormoneRev. Sep 2026

Tesamorelin

Tesamorelin (stabilized GHRH analogue)

Strong

An FDA-approved GHRH analogue that reduces visceral fat, now also studied for cognition in older adults at Alzheimer's risk.

Growth HormoneRev. Sep 2026

MK-677

Ibutamoren (oral ghrelin receptor agonist)

Moderate

A non-peptide, orally active ghrelin receptor agonist that raises growth hormone and IGF-1. Completed but did not pass Phase 3 for approval.

Growth HormoneRev. Sep 2026

Sermorelin

Sermorelin (GHRH 1-29 analogue)

Moderate

A GHRH fragment historically approved as a diagnostic and pediatric GH agent, now used in compounded anti-aging research.

Growth HormoneRev. Sep 2026

GHRP-6

Growth Hormone Releasing Peptide 6

Moderate

An early GH secretagogue hexapeptide that strongly stimulates growth hormone and appetite.

Growth HormoneRev. Sep 2026

IGF-1 LR3

Long R3 Insulin-like Growth Factor 1

Preliminary

A long-acting analogue of IGF-1 studied in animal models for muscle growth and tissue repair.

Growth HormoneRev. Sep 2026

Hexarelin

Hexarelin (growth hormone secretagogue)

Moderate

A potent synthetic GH-releasing hexapeptide studied for growth hormone release and direct cardioprotective effects.

Growth HormoneRev. Sep 2026

GHRP-2

Pralmorelin (Growth Hormone Releasing Peptide 2)

Moderate

A second-generation GH secretagogue approved in Japan as a diagnostic agent, producing strong GH release with less appetite effect than GHRP-6.

Growth HormoneRev. Sep 2026

Ghrelin

Ghrelin (endogenous growth hormone secretagogue)

Strong

The body's own hunger hormone and the natural trigger for growth hormone release, and the template for the entire GHRP peptide class.

Growth HormoneRev. Sep 2026

GHRP-1

Growth Hormone Releasing Peptide 1

Moderate

An early synthetic growth hormone releasing peptide, part of the first generation that established the GHRP class.

Growth HormoneRev. Sep 2026

Somatropin

Somatropin (recombinant human growth hormone)

Strong

FDA-approved recombinant human growth hormone used for growth hormone deficiency and several other approved indications.

Growth HormoneRev. Sep 2026

Somatostatin

Somatostatin (growth hormone inhibiting hormone)

Strong

The natural hormone that switches off growth hormone release; its analogues like octreotide are approved drugs.

Growth HormoneRev. Sep 2026