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Modified GRF 1-29 dosage and evidence

Written by Reviewed Sep 2026

Limited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.9 reported

The short answer

Sold as "CJC-1295 without DAC", which makes no sense.

Evidence grade for Modified GRF 1-29: Limited. The rule: people have taken it in a published study, but fewer than 100 of them. The sum on this page: 1 completed trial, none stating how many people. A grade counts how much has been done to people, not whether it works.

People given it
0
Human studies
1
Found nothing
0

Dose

No human dose established

Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose.

1 completed trial, 0 people given it

9 effects reported, 5 unwanted, 4 wanted, by people using it, not a trial

Goal pages: Fat loss and metabolism, Hormones and growth hormone

In plain English

In plain English, from Aaron

This is how I would explain it to a friend. The evidence, with the numbers, is further down the page.

This is a shot that tells your pituitary to release its own growth hormone. It is sold as CJC-1295 without DAC. That name is backwards. The DAC is the part that makes a molecule CJC-1295 in the first place. Take it off and you have a different, much shorter acting drug. The famous human study everyone quotes was run on the version with the DAC.

What people take it for

  • Better sleep and deeper recovery.
  • Losing fat while holding onto muscle.
  • Feeling younger without taking growth hormone itself.
  • Healing faster from hard training.

What studies in people showed

This exact version has never been tested in a human being. Not once. The study on the vendor page is a different drug. In that one, healthy adults got the version with the DAC. Growth hormone rose 2 to 10 times for 6 days or more. IGF-1 rose 1.5 to 3 times for 9 to 11 days. It stayed in the body for about 6 to 8 days. You cannot carry those numbers over, because the part that made it last that long is the part your vial does not have. The plain parent peptide has been given to people. Eleven short children got it every night for 6 months. They grew faster. But their growth hormone pattern over 24 hours did not change, and their IGF-1 did not go up in any real way. There is one more thing worth knowing. When Danish customs seized these powders and tested them, the contents had an extra amino acid stuck on the end. What was in the vials was not what the label said.

What people report

Reports, not study results

The good

  • Deeper sleep in the first two weeks is the most common report.
  • People say they get hungry, which they take as a sign it is working.
  • Some report better skin and faster recovery between workouts.
  • It is usually stacked with ipamorelin because the two hit different switches.

The bad

  • Tingling or numb hands, and puffy fingers and ankles from holding water.
  • Joint and muscle aches, listed for this whole drug family in a 2026 review.
  • Blood sugar can drift up. The same review lists raised prolactin and cortisol too.
  • Red, itchy lumps where the needle went in.
  • You may not be getting the drug at all. That is the seized powder finding, not a rumour.

Where these come from: The water retention, tingling, blood sugar and hormone effects come from a 2026 review of this drug family in clinic patients. The sleep, hunger and injection site reports come from peptide and bodybuilding forums.

My bottom line

The pharmacology here is real, but you are buying a name that does not match the molecule and quoting a trial of a different drug. If you want growth hormone benefits, sleep, lift and get your blood work looked at first, because that is where most people are actually leaking.

An opinion, not a finding. I am a coach, not a doctor.

What it has been measured to do

Measured in people

Goals Modified GRF 1-29 has been tested for in people, biggest studies first. We count only what the studies on this page say, so the real numbers may be higher.

What people using it report

Real people telling you what happened to them. Nobody checked it, and the people who post are not a fair sample, so it cannot prove anything works. It is still the best guide on this page to what people actually do with Modified GRF 1-29, what they expect, and what goes wrong. The full account, including the negative reports, is below.

33 of the 36 indexed goals have no study of any kind behind Modified GRF 1-29

No study in people, animals or cells on this page reports a result for these. That does not prove Modified GRF 1-29 does nothing for them. It does mean anything you have heard about Modified GRF 1-29 and one of these did not come from a study cited here.

Show full evidence

What is Modified GRF 1-29?

Sold as "CJC-1295 without DAC", which makes no sense. The DAC is the part that makes a molecule CJC-1295. The human study everyone quotes found growth hormone 2 to 10 fold higher for 6 days or more, with half a dose cleared in 5.8 to 8.1 days. That study used the DAC form. No human study of the version without DAC has been found.

Start with the name, because the name is the mistake.

The 2005 paper that created CJC-1295 tested three changed versions of GRF 1-29, a piece of the body's growth hormone releasing hormone. Each was built to stick to albumin, the main protein in your blood. The winner was named CJC-1295. That paper defines it as GRF 1-29 with four amino acids swapped, plus an extra chemical hook added at one end. The hook is what grabs albumin. It is called the Drug Affinity Complex, or DAC. Both the four swaps and the hook are part of the definition.

So a product sold as "CJC-1295 without DAC" is the four-swap peptide with the defining half removed. It is a real compound. It is just not CJC-1295, and it does not behave like CJC-1295. The whole reason CJC-1295 lasts for days is that it hangs on to albumin.

On their own, the four swaps protect the peptide from an enzyme called DPP-4. That enzyme chews up the body's own growth hormone releasing hormone (GHRH) within minutes. So modified GRF 1-29 is best seen as a tougher sermorelin. It is the same 29 amino acid piece, harder to break down, pressing the same switch in the pituitary gland. It still works in bursts, and it is still short-acting.

The human record is where this matters. CJC-1295 with DAC has a published study in healthy adults, tested against a dummy shot. Sermorelin, which is plain GRF 1-29, has decades of human research and was an approved medicine. The version without DAC has neither. It shows up in the research mainly through drug testing labs. In 2019, Danish customs seized doping powders and had them tested. Modified GRF 1-29 was among them. But the seized powder had an extra amino acid, glycine, stuck on one end. What was in the vials was not even the compound named on the label.

How does Modified GRF 1-29 work?

It copies growth hormone releasing hormone (GHRH). It presses the GHRH switch in the pituitary, the small gland under the brain. That tells the gland to release growth hormone, which then raises IGF-1, a growth signal made mostly in the liver. The four amino acid swaps protect it from DPP-4, the enzyme that breaks down the natural hormone. So it lasts somewhat longer in the blood than a few minutes. It does not stick to albumin. Growth hormone still comes out in bursts. How much comes out depends on your own pituitary, and on somatostatin, the body's brake on growth hormone. That is the real-life difference between a peptide that nudges your gland and a shot of growth hormone itself.

What have studies in people found about Modified GRF 1-29?

None for this compound. The human evidence here belongs to two close relatives: CJC-1295 with DAC, and plain sermorelin.

  • CJC-1295 with DAC, in healthy adults, compared with a dummy shot: growth hormone up 2 to 10 fold for 6 days or more, IGF-1 up 1.5 to 3 fold for 9 to 11 days, and half a dose cleared in 5.8 to 8.1 days.
  • Sermorelin (GRF 1-29 amide) in 11 short children over 6 months: they grew faster, but their growth hormone over 24 hours and their IGF-1 did not clearly change.
  • Modified GRF 1-29 without the DAC: no human study of how long it lasts, no human study of whether it works, and no registered trial found.
  • The only published record naming this compound directly is a 2019 lab test of seized doping powder. The powder had an extra amino acid, glycine, stuck on one end.

What this does not tell you: You cannot borrow the CJC-1295 numbers. The DAC is the reason that molecule lasts for days, so taking it off removes the very thing the study measured. You cannot borrow the sermorelin record as it stands either. The four swaps were added on purpose to change how fast the peptide gets broken down. What is left is a sensible idea with no human measurement. And in this group of products, seized powder has again and again turned out to be a different molecule from the one on the label.

What do people who took Modified GRF 1-29 report?

This is what real people say happened to them, good and bad. Nobody measured it. A report cannot tell a real effect from the lift people get just from expecting it to work, from a diet or training change made at the same time, or from what was really in the vial. We still put it near the top. It is the next best thing to a study in people: what happens when real people use it, including what goes wrong.

  • Almost nothing describes it on its own. The pattern is a pairing with a ghrelin mimetic, usually ipamorelin or GHRP-2, and the threads that set out to discuss using it by itself attract very little practical experience in reply. That means essentially no self-report separates this peptide from the one injected with it.
  • Doses described cluster around 100 mcg of each peptide, taken once or twice a day, most often at night on an empty stomach with food avoided for a couple of hours either side. A forum poll on frequency split roughly sixty to forty in favour of a single evening injection, and figures up to 250 mcg at night appear. These schedules come from forum convention rather than any published human protocol.
  • A warm facial flush lasting around half an hour, compared by people to a niacin reaction, is the most consistently described immediate effect, and posters treat its presence or absence as a rough signal about the vial. The sharpest sourcing complaint in these threads comes from someone using a premixed blend who describes no flush and no appetite change at all and concludes the blend was not what it claimed.
  • Timeframes people describe run long. Sleep disruption in the first week or two that then settles, then changes in body composition and skin quality described across eight weeks to six months. Those accounts come from people simultaneously training, dieting and injecting a second peptide, which they generally say themselves.
  • Negatives described include carpal tunnel type symptoms in the hands appearing around week five, daytime sleepiness, early insomnia, and appetite increase attributed to the paired ghrelin mimetic. The strict food timing is repeatedly described as the hardest part to sustain.
  • There is a live disagreement about whether the paired compound raises estrogen and prolactin, a hormone that can cause breast changes, with experienced users who describe themselves as estrogen sensitive reporting no trouble and others warning about it.

Sources: Growth hormone peptide threads on ExcelMale, found by site-restricted search and read directly, September 2026. Nothing above is attributed to any specific post and no post is reproduced.

The state of the research

There is a second reason the human data runs thin here, and it is about money, not science. A company called ConjuChem developed CJC-1295 and took it into human trials. It never went on to approval. The version without DAC was never a drug candidate at all. It became a product because bodybuilding suppliers could make a cheap GHRH piece that resists DPP-4. Pairing it with a ghrelin-type peptide such as ipamorelin also became a standard gray-market routine. Nobody paid for a trial of a peptide nobody could patent or sell as a medicine. So the missing data is partly about money, not just a verdict on the peptide. Still, a reason the evidence is missing is not the same as having the evidence.

The evidence, in charts

Fig. 1a · how many people

2studies in people cited, but none says how many people took part

number of people not stated

We do not draw a total, because none of the studies in people on this page gives one. Read the sources below for what each study measured.

We read the number of people from the source lines on this page. Where a line gives no number, we count nothing for it. We do not guess.

Fig. 1b · evidence mix

2 of 5 sources here are studies in people. The rest are not.

05 sources
  • Study in people · done in people240%
  • Animal study · done in animals120%
  • Lab (cells in a dish) · cells or tissue120%
  • Review of studies · sums up other studies120%

Counted from the list of sources on this page. It counts only what we cite, so there may be more studies out there. A review counts once, however many studies it sums up.

Fig. 2 · evidence over time

The studies cover 5 different years, 1988 to 2026, counted from the list of sources on this page.

Fig. 3 · legal status at a glance

Not approved in any of the four countries shown. This is what the law says, not a verdict on the science. See Legal status below for the full text and any notes.

Fig. 4 · how much does what

Nobody has tested different amounts in people

This chart would show how the effect changes as the amount goes up. For this compound, nobody has measured that in people. So we leave it empty. We will not borrow an animal chart and pretend it works the same in people.

Waiting on a study nobody has runMaking one takes a study that gives different amounts to different groups of people and compares them. Nobody has paid for that for this compound.

Fig. 5 · what the molecule is

Kind of compound
Peptide
Molecule weight
About 3,368 Da for the tetrasubstituted 29 amino acid peptide without the DAC maleimide.
Half-life
About 6 daysLong, 1 to 7 days
Chain length
None on file

Half-life as stated on file: Not measured in humans for this compound. For scale, native GRF 1-29 is cleared within minutes, while the albumin-bound DAC version was measured at about 6 days in healthy adults.

No amino acid sequence is on file for Modified GRF 1-29, so none is drawn rather than guessed from a name.

The studies we cite

  • Study in people2006
    Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.

    The peptide did move hormone levels, and this trial tested a different version from the one usually sold. Healthy adults aged 21 to 61 got either rising doses or a dummy, with nobody knowing which. A single injection pushed growth hormone several fold higher for six days or more, and IGF-1 stayed up for a week and a half. The body took about a week to clear half a dose. Nothing serious went wrong. Vendors quote this study for the plain form, which it never tested.

    Two randomised placebo-controlled double-blind ascending dose trials over 28 and 49 days in healthy subjects aged 21 to 61. A single injection raised mean plasma growth hormone 2 to 10 fold for 6 days or more and IGF-1 1.5 to 3 fold for 9 to 11 days, with an estimated half-life of 5.8 to 8.1 days and IGF-1 still above baseline for up to 28 days after multiple doses. No serious adverse reactions. This is the DAC form. It is the study quoted on vendor pages for the non-DAC product, and it is not a study of that product.

  • Study in people1988
    Subcutaneous treatment with growth hormone-releasing hormone for short stature.

    Eleven short children grew faster on the original peptide, and their hormone readings never moved. Each had a shot under the skin every evening for six months. All of them grew quicker. Yet their growth hormone across a full day looked the same before, during and after, both in how often it pulsed and how big the pulses were. IGF-1 did not clearly shift either. Growing faster and showing a changed hormone profile turn out to be two different things.

    The unmodified parent peptide in people. Eleven short children with normal growth hormone secretion were given GRF 1-29 amide at 5 micrograms per kilogram subcutaneously each evening for 6 months. Growth velocity increased in all of them, but the 24 hour growth hormone secretory profile did not differ before, during or after treatment, pulse frequency and amplitude were unchanged, and the IGF-1 increments were not significantly different at any interval. A useful reminder that a growth effect and a measurable hormone profile change are not the same thing.

    This study gave people GRF 1-29 amide (the unmodified parent peptide), not Modified GRF 1-29. It is here because it belongs on the record, and it is excluded from every count on this page.

  • Review of studies2026
    The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.

    A review of growth hormone peptides that people inject on their own. It keeps CJC-1295 with DAC apart from the version without it. It sorts the whole group by how good the evidence is, from approved-drug level down to no human studies at all. Reported side effects across the group include higher prolactin and cortisol, appetite changes, blood sugar problems, water retention, muscle and joint pain, and shot-site reactions. It also flags doubt about what is really in unregulated products.

    A narrative review that explicitly separates CJC-1295 with DAC from CJC-1295 without DAC and stratifies the whole class into evidence tiers from regulatory-grade randomised data down to a complete absence of human studies. Reported adverse effects across the class include prolactin and cortisol elevations, appetite change, dysglycaemia, fluid retention, myalgia and arthralgia, and injection site reactions, alongside uncertainty about what is actually in unregulated product.

  • Animal study2005
    Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.

    In rats. This is the paper that created CJC-1295. Scientists made versions of the peptide that stick to albumin, a blood protein. In rats, the best one released far more growth hormone than the plain peptide, and was still in the blood days later. The paper defines CJC-1295 as including that sticky hook. So a product without it is not CJC-1295.

    The paper that defines the molecule. Three maleimido hGRF 1-29 derivatives were conjugated to human serum albumin, all resisted dipeptidylpeptidase IV and were active in cultured rat pituitary cells. In male Sprague Dawley rats the best compound gave a 4-fold larger growth hormone area under the curve over 2 hours than plain hGRF 1-29 and was still detectable in plasma beyond 72 hours. CJC-1295 is defined here as the tetrasubstituted hGRF 1-29 with the added maleimidopropionamide lysine at the C terminus, which is why a product without that group is not CJC-1295. Rats, not people.

  • Lab (cells in a dish)2019
    Glycine-modified growth hormone secretagogues identified in seized doping material.

    In a lab, on seized powder. Danish customs seized doping powders and had them tested. They held copies of GHRP-2, GHRP-6, ipamorelin and modified GRF 1-29. Every one had an extra amino acid stuck on one end. What was in the vials was not quite what the label said.

    Powders seized by Danish customs were analysed by high resolution mass spectrometry against reference standards and identified as analogues of GHRP-2, GHRP-6, ipamorelin and modified GRF 1-29. In every case the detected material carried an extra glycine at the N terminus. What was in the vials was a modified version of the compound named on them, which is a product identity problem rather than a pharmacology finding.

Where to buy Modified GRF 1-29

29 sellers list Modified GRF 1-29 in our latest read. They are ranked by trust score, then by archive rating, then by certificate tier, then by the lowest price per milligram. Archive evidence is counted before source-backed. Each path is out of 4, and the two are not added. A higher price does not raise the score. The letter is the certificate chip. 0 of them have a published certificate that names Modified GRF 1-29.

Some seller links may pay this site when you buy through them. A payment never changes a seller's tier or rank, and no seller has a say in any page.

SellerTrust scoreVial sizesFrom, per mgCertificate for Modified GRF 1-29Seller link
Core Peptides
75 StrongSource-backed 4 of 4. Archive evidence 2 of 4.A
5 mg$8.20None found for Modified GRF 1-29View
NuLife Peptides
67 FairSource-backed 3 of 4. Archive evidence 2 of 4.B
5 mg$8.50None found for Modified GRF 1-29View
Pivot Labs Global
53 FairSource-backed 2 of 4. Archive evidence 1 of 4.C
10 mg$14.5None found for Modified GRF 1-29View
Oasis Labs
49 WeakSource-backed 3 of 4. Archive evidence 3 of 4.A
5 mg$7.80None found for Modified GRF 1-29View
Biotech Peptides
49 WeakSource-backed 3 of 4. Archive evidence 3 of 4.A
5 mg$9.20None found for Modified GRF 1-29View
CoMo Peptides
49 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A
4 mg, 5 mg, 10 mg$4.75None found for Modified GRF 1-29View
Liberty Peptides
49 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A
5 mg$7.80None found for Modified GRF 1-29View
Peptides Kingdom
49 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A
5 mg, 10 mg$9.00None found for Modified GRF 1-29View
Research Purpose Labs
49 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A
5 mg$9.20None found for Modified GRF 1-29View
Onyx Research
49 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A
5 mg$9.90None found for Modified GRF 1-29View
Peptide Shop A
49 WeakSource-backed 2 of 4. Archive evidence 2 of 4.B
5 mg$9.20None found for Modified GRF 1-29View
Behemoth Labz
49 WeakSource-backed 3 of 4. Archive evidence 1 of 4.B
5 mg$22.4None found for Modified GRF 1-29View
Melanotan Express
46 WeakSource-backed 3 of 4. Archive evidence 1 of 4.B
2 mg$16.1None found for Modified GRF 1-29View
Peptides World
39 WeakSource-backed 4 of 4. Archive evidence 1 of 4.B
5 mg$7.98None found for Modified GRF 1-29View
Canlab International
37 WeakSource-backed 1 of 4. Archive evidence 1 of 4.C
5 mg$11.0None found for Modified GRF 1-29View
Limitless Biotech ST
36 WeakSource-backed 1 of 4. Archive evidence 1 of 4.C
5 mg, 8 mg, 10 mg$8.20None found for Modified GRF 1-29View
Evolution Peptides USA
36 WeakSource-backed 1 of 4. Archive evidence 1 of 4.C
2 mg$17.0None found for Modified GRF 1-29View
Lejian Biotech Peptide
35 WeakSource-backed 1 of 4. Archive evidence 1 of 4.C
5 mg$14.0None found for Modified GRF 1-29View
AminoQuest Labs
28 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C
5 mg$11.0None found for Modified GRF 1-29View
Peptides Sales
28 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C
2 mg$15.0None found for Modified GRF 1-29View
Profound Aminos
25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C
5 mg, 10 mg$6.50None found for Modified GRF 1-29View
Peptide Science LLC
25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C
2 mg, 5 mg$9.90None found for Modified GRF 1-29View
USA Peptide Sciences
25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C
2 mg, 5 mg$9.90None found for Modified GRF 1-29View
Huaian Hanyou Peptide
25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C
5 mg$14.0None found for Modified GRF 1-29View
MJA Peptides
25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C
5 mg$14.0None found for Modified GRF 1-29View
ZL Peptides
25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C
5 mg$14.0None found for Modified GRF 1-29View
Oneday Compounds
23 InsufficientSource-backed 4 of 4. Archive evidence 1 of 4.Letter withheld
5 mg$3.90None found for Modified GRF 1-29View
AMC Essentials
16 InsufficientSource-backed 1 of 4. Archive evidence 0 of 4.Letter withheld
5 mg$8.00None found for Modified GRF 1-29View
Tydes
15 InsufficientSource-backed 1 of 4. Archive evidence 0 of 4.Letter withheld
10 mg$7.00None found for Modified GRF 1-29View
  • LC Lab-confirmed: the issuing laboratory echoed this certificate back
  • A Current certificate, independent laboratory named, laboratory not yet checked
  • B Certificate published, but no laboratory link, older than a year, or the laboratory did not recognise the published lookup
  • C No certificate could be read

Every listing and vial size for Modified GRF 1-29 · How the trust score is counted

Sellers named on the price pages are ranked by certificate tier, then price, and any affiliate income is disclosed there. Naming a seller is not a recommendation to buy or use anything.

Common questions

Has Modified GRF 1-29 been tested in people?

Yes. 0 people given it across 1 completed trial cited here, 0 of which found nothing. Sold as "CJC-1295 without DAC", which makes no sense.

What is the Modified GRF 1-29 dosage?

No human dose established. Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose. 1 completed trial, 0 people given it

Is Modified GRF 1-29 FDA-approved?

Not approved for any use, and not reviewed. Sermorelin, the unchanged form of GRF 1-29, was an approved medicine in the United States. It is no longer sold in its original form. Tesamorelin, a different copy of the brain's growth hormone release signal (GHRH), is approved for the shifted body fat some people with HIV get.

Is mod GRF 1-29 the same as CJC-1295?

No, and the shop name gets it backwards. The 2005 paper defines CJC-1295 as the four-swap GRF 1-29 plus the chemical hook that grabs albumin. Take the DAC away and it is no longer CJC-1295. You have the four-swap piece on its own, and it does not last for days.

How long does it last?

Nobody has measured it in people. Plain GRF 1-29 is cleared in minutes, and the four swaps slow the enzyme that clears it. So expect something short that works in bursts. Do not expect the roughly 6 days it takes the body to clear half of the DAC version.

Is it the same as sermorelin?

Close relatives. Sermorelin is plain GRF 1-29 amide. It was an approved medicine, with real human data. Modified GRF 1-29 is the same piece with four amino acids swapped so it breaks down more slowly. Same switch in the pituitary, same burst pattern. Only sermorelin has been given to people in published studies.

Why is it usually stacked with ipamorelin?

Because they press two different switches. A GHRH copy works on the GHRH switch. A ghrelin copy such as ipamorelin works on a second switch, the growth hormone secretagogue receptor. In published studies of these peptides, pressing both gives a bigger burst of growth hormone than either alone. No study has tested modified GRF 1-29 with ipamorelin itself.

Is what I am buying actually mod GRF 1-29?

Often not. Danish customs sent seized growth hormone peptide powders for lab testing. The modified GRF 1-29 had an extra amino acid, glycine, stuck on one end. So did the GHRP-2, GHRP-6 and ipamorelin from the same seizure. That is the most solid thing known about what is actually sold under this name.

What are the reported side effects?

For this group of peptides as a whole, a 2026 review lists higher prolactin and cortisol (a stress hormone), appetite changes, blood sugar problems, water retention, muscle and joint pain, and problems where the shot goes in. None of that has been checked for this compound itself, because no human study of it exists.

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