Sermorelin with GHRP-2 and GHRP-6 dosage and evidence
Written by Aaron CuhaReviewed Sep 2026
The short answer
Sermorelin with GHRP-2 and GHRP-6 is an old pharmacy-made triple, usually 3 mg of each in a 9 mg vial, or 2 mg of each in a 6 mg vial.
Evidence grade for Sermorelin with GHRP-2 and GHRP-6: Limited. The rule: people have taken it in a published study, but fewer than 100 of them. The sum on this page: 2 completed trials, 9 people given it. A grade counts how much has been done to people, not whether it works.
- People given it
- 9
- Human studies
- 2
- Found nothing
- 0
Dose
No human dose established
Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose.
2 completed trials, 9 people given it
6 effects reported, 5 unwanted, 1 wanted, by people using it, not a trial
Goal pages: Fat loss and metabolism, Hormones and growth hormone
In plain English
In plain English, from Aaron
This is how I would explain it to a friend. The evidence, with the numbers, is further down the page.
An old compounded blend, usually 3 mg of each in a 9 mg vial. Three names on the label. But two of the three hit the same hunger switch. So the label says thirds and your body sees a two to one split.
What people take it for
- Better sleep.
- Eating more.
- Losing fat and holding muscle.
- Recovery.
What studies in people showed
The three way mix has never been tested. One GHRP plus GHRH has been. A 24 hour drip of that pair beat GHRH alone in healthy older adults. Thirty days of the GHRP alone kept growth hormone more than 1.8 times higher at day 14 and day 30. Sermorelin was an approved medicine and was compared against growth hormone itself in children who did not make enough. GHRP-6 has a human study too, just not an effect study. Nine healthy men got it by drip. Half life about 2.5 hours. The math: mix 9 mg with 3 mL and every unit mark carries 10 micrograms of each. Draw 20 units and you get 200 micrograms of sermorelin and 400 micrograms hitting the hunger switch, because both GHRPs add up there.
What people report
Reports, not study results
The good
- Deep sleep in the first weeks.
The bad
- Hard hunger soon after the shot. Two of the three ingredients cause it.
- Flushing and a warm face.
- Water retention and tingling hands at bigger draws.
- Weight gain people struggle to separate from the eating.
- Lots of people drop this for a sermorelin and ipamorelin blend, and the hunger is why.
Where these come from: Clinic write-ups, men's health forums and peptide forums. The appetite effect is backed by a proper human study of one of the ingredients.
My bottom line
Two hunger peptides in one vial is a choice, and the seller made it for you. If you are cutting, this is the wrong blend.
An opinion, not a finding. I am a coach, not a doctor.
What it has been measured to do
Measured in people
Goals Sermorelin with GHRP-2 and GHRP-6 has been tested for in people, biggest studies first. We count only what the studies on this page say, so the real numbers may be higher.
- Feeling less hungryno headcount stated · 1 study
- Growth hormone and IGF-1no headcount stated · 1 study
What people using it report
Real people telling you what happened to them. Nobody checked it, and the people who post are not a fair sample, so it cannot prove anything works. It is still the best guide on this page to what people actually do with Sermorelin with GHRP-2 and GHRP-6, what they expect, and what goes wrong. The full account, including the negative reports, is below.
34 of the 36 indexed goals have no study of any kind behind Sermorelin with GHRP-2 and GHRP-6
No study in people, animals or cells on this page reports a result for these. That does not prove Sermorelin with GHRP-2 and GHRP-6 does nothing for them. It does mean anything you have heard about Sermorelin with GHRP-2 and GHRP-6 and one of these did not come from a study cited here.
Show full evidence
What is Sermorelin with GHRP-2 and GHRP-6?
Sermorelin with GHRP-2 and GHRP-6 is an old pharmacy-made triple, usually 3 mg of each in a 9 mg vial, or 2 mg of each in a 6 mg vial. Two of the three press the same hunger hormone switch. So this is two ways of working, with one of them given twice. And the second one is the peptide with the strongest hunger effect in the family.
This blend is older than most of the market, and pharmacies still send it out. The reason given is that GHRP-2 and GHRP-6 act a bit differently, and using both covers more ground. But both press the same switch, the hunger hormone switch. So the vial has one target hit by two drugs, and a separate target hit by the third.
Here is what that means in the syringe. Take a 9 mg vial with 3 mg of each, mixed with 3 mL of water. Each mL holds 3 mg of powder in all, and 1 mg of each peptide. One mark on a 100 unit insulin syringe holds 10 micrograms of each. At a 20 unit draw you have taken 200 micrograms of sermorelin, and 400 micrograms of hunger-switch peptide in total. That is because the two GHRPs add up at the same switch. The label shows three equal parts. Your body sees a two to one split.
GHRP-6 has the strongest hunger effect in the group. GHRP-2 also makes healthy men eat more, as measured in a controlled study. With both in one vial, hunger is the one thing this blend reliably delivers. And there is no way to cut it without cutting the GHRH part you presumably wanted.
On evidence, pairing the two kinds of drug has been tested. In healthy older adults, a 24 hour drip of a hunger-hormone type peptide with GHRH pushed out more growth hormone than GHRH alone, and more than the peptide alone. That study used one GHRP, by drip, in a research unit. Sermorelin has the history with regulators. It was once an approved medicine, based on children short of growth hormone. That includes a study comparing it with growth hormone itself. GHRP-6 has been measured in nine healthy men, and half of it was gone in about 2.5 hours. None of that describes this vial.
How does Sermorelin with GHRP-2 and GHRP-6 work?
Sermorelin is a copy of the first part of GHRH, the brain's growth hormone switch. It presses the GHRH switch and makes each burst of growth hormone bigger. GHRP-2 and GHRP-6 are both small peptides that press the hunger hormone switch. That sets off a burst of growth hormone and pushes against the body's brake on it. Both also drive hunger through that same switch. All three end at growth hormone release from the pituitary gland, and then IGF-1 made by the liver.
What have studies in people found about Sermorelin with GHRP-2 and GHRP-6?
No study of the triple. Pairing one GHRP with GHRH has been shown to raise growth hormone more than either alone, using drips.
- GHRH plus one GHRP: in healthy older adults, over a 24 hour drip, the pair raised growth hormone more than either alone.
- GHRP-2: makes healthy men eat more. 30 days of nonstop drip kept growth hormone raised.
- Sermorelin: evidence from when it was approved, in children short of growth hormone.
- GHRP-6: only measured for how fast it leaves the body, after single doses in people. No study of whether it works.
- Two GHRPs together: never studied in people.
- The blend: no published study and no listed trial.
What this does not tell you: Every result in this research is a hormone level in the blood. No study of any of these three has measured body shape, recovery or daily function in healthy adults, over the time people use them.
What do people who took Sermorelin with GHRP-2 and GHRP-6 report?
This is what real people say happened to them, good and bad. Nobody measured it. A report cannot tell a real effect from the lift people get just from expecting it to work, from a diet or training change made at the same time, or from what was really in the vial. We still put it near the top. It is the next best thing to a study in people: what happens when real people use it, including what goes wrong.
- Strong hunger soon after the shot. This is the main report.
- Deep sleep in the first weeks.
- Flushing and warmth in the face.
- Water retention and tingling hands at bigger draws.
- Weight gain that people find hard to tell apart from the extra eating.
- People dropping the GHRP-6 and moving to a sermorelin plus ipamorelin blend for that reason.
Sources: Clinic write-ups, men's health forums and peptide forums. Uncontrolled self-reports, except the appetite effect, which is supported by controlled human work on GHRP-2.
The state of the research
The two-GHRP design is the thing to understand before buying this. GHRP-2 and GHRP-6 may differ a bit in how much they raise the stress hormone cortisol or the hormone prolactin. But both press one switch. So putting them together mostly means more pressure on that switch, not a new ability. The result you can see is hunger. Both drive it, and it is the most steady report on this blend.
The second point is that a prescription does not mean a study. Pharmacy-made drugs are not FDA approved. Nobody checks them for safety or whether they work. The only ingredient here with a history with regulators got it in children with a diagnosed shortage. Those are not the people buying a bedtime vial.
The evidence, in charts
Fig. 1a · how many people
9people, across 1 study in people cited here
| Study | People | Share |
|---|---|---|
| European Journal of Pharmaceutical Sciences 2013 | 9 | 100% |
The whole total is one study of 9. Counts are the number of people each study on this page says it signed up. That includes studies that only watched people and gave nobody the compound. 3 more studies in people give no headcount and are not counted here. Studies still signing people up are left out, and only studies cited on this page are counted.
Fig. 1b · evidence mix
All 4 sources here are studies in people.
- Study in people · done in people4100%
Counted from the list of sources on this page. It counts only what we cite, so there may be more studies out there. A review counts once, however many studies it sums up.
Fig. 2 · evidence over time
The studies cover 4 different years, 1993 to 2013, counted from the list of sources on this page. The newest source on file is from 2013, more than five years ago. Research on it may have gone quiet.
Fig. 3 · legal status at a glance
US
Not approved
UK
Not approved
AU
Not approved
CA
Not approved
Not approved in any of the four countries shown. This is what the law says, not a verdict on the science. See Legal status below for the full text and any notes.
Fig. 4 · how much does what
Nobody has tested different amounts in people
This chart would show how the effect changes as the amount goes up. For this compound, nobody has measured that in people. So we leave it empty. We will not borrow an animal chart and pretend it works the same in people.
Fig. 5 · what the molecule is
- Kind of compound
- Blend
- Molecule weight
- Not on file
- Half-life
- Stated in words, not a numbersee the exact wording below
- Chain length
- None on file
Half-life as stated on file: Not defined for the blend. All three components clear quickly, and the published figure for the growth hormone releasing peptide component is in the overview above.
No amino acid sequence is on file for Sermorelin with GHRP-2 and GHRP-6, which is expected: a blend is not built from amino acids.
Fig. 6 · what is in the vial
33.3%of a 9 mg Sermorelin with GHRP-2 and GHRP-6 vial is Sermorelin
- Sermorelin3 mg33.3%
- GHRP-23 mg33.3%
- GHRP-63 mg33.3%
What the label says is in a standard vial. It is not a dose, and not a lab test. The seller fixes the mix, so when you draw the amount you want of one ingredient, you get a set amount of every other one with it. No study has tested this mix in people or animals.
The studies we cite
- Study in people2004Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women
Pairing one hunger-hormone type peptide with GHRH does raise growth hormone more than either one alone. This was shown in healthy older adults. The pair went in through a drip over 24 hours. A month of nonstop GHRP-2 kept growth hormone bursts running nearly twice as high as at the start, with IGF-1 holding steady. Note what that study used. One hunger-hormone type peptide, not two. Nothing here supports adding a second peptide that presses the very same switch.
In healthy older adults, a 24 hour infusion of GHRP-2 combined with GHRH drove growth hormone secretion more than GHRH alone and more than GHRP-2 alone, and 30 days of continuous GHRP-2 sustained pulsatile growth hormone more than 1.8-fold at days 14 and 30 with IGF-1 on a plateau. One GHRP plus GHRH, by infusion, in a research setting. Nothing here supports adding a second agent at the same receptor.
- Study in people2005Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men
GHRP-2 makes healthy men eat more, the same way the hunger hormone ghrelin does. This vial holds two peptides that press that same hunger switch. Their effects there add up. They do not cancel out. So the hunger is not a quirk of one ingredient that the other might balance. It is the expected result of stacking two drugs that do the same thing.
GHRP-2 increased food intake in healthy men in the way ghrelin does. Both ghrelin-receptor components of this blend drive appetite, and their effects at that receptor add.
- Study in people2013Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers
This study measured only how fast GHRP-6 leaves the body. Nine healthy men got single doses into a vein. It spread through the body in under eight minutes, and most of it was gone within a few hours. In four of the nine, levels jumped oddly on the way down, and nobody has explained why. Nine men, single doses, and nothing measured about whether the peptide helps anyone with anything.
Nine healthy men, single intravenous boluses of 100, 200 and 400 micrograms per kilogram. Distribution half-life 7.6 plus or minus 1.9 minutes, elimination half-life 2.5 plus or minus 1.1 hours, with atypical concentration spikes during elimination in four of nine subjects.
- Study in people1993A comparative study of growth hormone (GH) and GH-releasing hormone(1-29)-NH2 for stimulation of growth in children with GH deficiency
Sermorelin was compared head to head with growth hormone itself, in children who lacked it. That is the sort of evidence behind sermorelin once being an approved medicine. Look at who was in it. Children with a diagnosed shortage, treated so they would grow. That is a long way from a healthy adult drawing sermorelin out of a three-peptide vial.
GHRH 1-29, the molecule sold as sermorelin, compared against growth hormone itself for stimulating growth in children with growth hormone deficiency. The kind of evidence behind sermorelin's former approval, in a paediatric deficiency population.
Where to buy Sermorelin with GHRP-2 and GHRP-6
1 seller lists Sermorelin with GHRP-2 and GHRP-6 in our latest read. They are ranked by trust score, then by archive rating, then by certificate tier, then by the lowest price per milligram. Archive evidence is counted before source-backed. Each path is out of 4, and the two are not added. A higher price does not raise the score. The letter is the certificate chip. 0 of them have a published certificate that names Sermorelin with GHRP-2 and GHRP-6.
Some seller links may pay this site when you buy through them. A payment never changes a seller's tier or rank, and no seller has a say in any page.
| Seller | Trust score | Vial sizes | From, per mg | Certificate for Sermorelin with GHRP-2 and GHRP-6 | Seller link |
|---|---|---|---|---|---|
| Umbrella Labs | 39 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A | 6 mg | $10.00 | None found for Sermorelin with GHRP-2 and GHRP-6 | View |
- LC Lab-confirmed: the issuing laboratory echoed this certificate back
- A Current certificate, independent laboratory named, laboratory not yet checked
- B Certificate published, but no laboratory link, older than a year, or the laboratory did not recognise the published lookup
- C No certificate could be read
Every listing and vial size for Sermorelin with GHRP-2 and GHRP-6 · How the trust score is counted
Sellers named on the price pages are ranked by certificate tier, then price, and any affiliate income is disclosed there. Naming a seller is not a recommendation to buy or use anything.
Common questions
Has Sermorelin with GHRP-2 and GHRP-6 been tested in people?
Yes. 9 people given it across 2 completed trials cited here, 0 of which found nothing. Sermorelin with GHRP-2 and GHRP-6 is an old pharmacy-made triple, usually 3 mg of each in a 9 mg vial, or 2 mg of each in a 6 mg vial.
What is the Sermorelin with GHRP-2 and GHRP-6 dosage?
No human dose established. Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose. 2 completed trials, 9 people given it
Is Sermorelin with GHRP-2 and GHRP-6 FDA-approved?
Not approved as a combination. Sermorelin was once approved in the US, and was pulled from sale for business reasons. Neither GHRP has ever been approved.
Why are there two GHRPs in this?
More for sales reasons than for how the drugs work. Both press the same hunger hormone switch. So the vial gives you two ways of working, with one of them given twice.
What does a draw actually deliver?
Take a 9 mg vial with 3 mg of each, mixed with 3 mL of water. One unit holds 10 micrograms of each. A 20 unit draw is 200 micrograms of sermorelin and 400 micrograms of hunger-switch peptide in total, because the two GHRPs add up at the same switch.
Why am I so hungry on this?
Both GHRPs drive hunger through the hunger hormone switch. A controlled study in healthy men measured GHRP-2 making them eat more. With two of them in the vial, hunger is the effect you should expect.
Has the three-way combination been tested?
No. The pairing evidence for this kind of drug used one GHRP with GHRH, by drip, in healthy older adults.
Is a compounded blend better vetted than a research vial?
The supply chain is better. The evidence is the same. Pharmacy-made drugs are not FDA approved, and nobody checks them for safety or whether they work.