Weight loss in adults who are overweight or have obesity, and do not have diabetes
- Amount
- 2.4 mg as the ongoing dose, reached by stepping up over 16 weeks
- How often
- Once weekly
- How it is taken
- Shot under the skin
- How long
- 68 weeks including the step-up
- What was measured
- The main things measured: how much body weight changed, in percent, from the start to week 68, and how many people lost at least 5 percent. Also measured: weight in kilograms, heart and blood sugar risk factors, and how well people said they could move and function.
- What it cannot tell you
- Everyone also got diet and exercise coaching, so the schedule was never tested on its own. The drug cannot be separated from the program around it. People with diabetes were left out, so the numbers do not carry over to them. 68 weeks says nothing about year three. The study measured weight, not the health problems underneath it that people actually care about. The step-up exists because the drug is hard to handle, and 4.5 percent still stopped for gut side effects, with a study team watching over them.
Not advice. This is a record of a schedule, not a dose for you.