Humanin dosage and evidence
Written by Aaron CuhaReviewed Sep 2026
The short answer
Humanin is a tiny peptide made from mitochondrial DNA. In people it has been watched, not given. It falls with age, runs high in the children of people who lived to 100, tracks with heart and blood sugar risk, and rises in the muscle of people with one mitochondrial disease. No study has given it to people as a drug.
Evidence grade for Humanin: Limited. The rule: people have taken it in a published study, but fewer than 100 of them. The sum on this page: 1 completed trial, 30 people given it. A grade counts how much has been done to people, not whether it works.
- People given it
- 30
- Human studies
- 1
- Found nothing
- 0
Dose
No human dose established
Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose.
1 completed trial, 30 people given it
6 effects reported, 4 unwanted, 2 wanted, by people using it, not a trial
Goal pages: Fat loss and metabolism, Muscle and strength, Brain, memory and mood, Ageing and longevity
In plain English
In plain English, from Aaron
This is how I would explain it to a friend. The evidence, with the numbers, is further down the page.
Humanin is a tiny protein your own cells make inside their energy engines. It seems to protect cells when they are under stress. Scientists have measured it in people. Nobody has ever given it to a person as a drug. It is not approved. The vials sold online have never been through a single human trial.
What people take it for
- Living longer, because the children of people who reach 100 have more of it.
- Protecting the brain from Alzheimer's.
- Better blood sugar.
- A general sense of calm and wellness.
What studies in people showed
There are two kinds of human data here. Keep them apart. The first kind is measuring. Scientists took blood from people and checked their humanin. Older people have less. The adult children of people who lived to 100 have more. In one study that was 18 children of centenarians against 19 people the same age. People with early blood sugar trouble had less, 23 of them against 58 healthy people. In 94 people on kidney dialysis followed for 30 months, both very low and very high levels went with more heart trouble and death. Not just low. High too. In 30 adults, one bout of endurance exercise raised it. Lifting did not. The second kind is giving it to people. That has never happened. No trial has put humanin into anyone. So all of the above tells you what the body does on its own. None of it tells you what a shot does. In mice, a look-alike version improved metabolic health. In worms, more of it meant a longer life. Those are mice and worms.
What people report
Reports, not study results
The good
- One blogger took it twice a day for 15 days and described a sense of calm and wellness. That is one person.
- Vendor sites call it well tolerated. That is the seller talking.
The bad
- Sore skin where the shot went in.
- Headache and mild stomach upset.
- Feeling light-headed, mostly when taken on an empty stomach.
- Almost nobody is actually using this. Fewer reports means less is known, not that it is safer.
Where these come from: A single blog self-experiment, seen only as quoted on peptide vendor sites. The side effect list is from vendor and dosing-guide sites, not from any study. Reddit and the peptide forums had no real humanin threads at the time of review.
My bottom line
The measuring studies are real. Higher humanin goes with living longer. But higher HDL cholesterol goes with fewer heart attacks too, and the drugs that raised HDL failed. Nobody has tested a humanin shot in a person, so I would not put it in my body.
An opinion, not a finding. I am a coach, not a doctor.
What it has been measured to do
Measured in people
Goals Humanin has been tested for in people, biggest studies first. We count only what the studies on this page say, so the real numbers may be higher.
- Lasting longer, stamina30 people · 2 studies
- Blood sugar and insulin23 people · 1 study
What people using it report
Real people telling you what happened to them. Nobody checked it, and the people who post are not a fair sample, so it cannot prove anything works. It is still the best guide on this page to what people actually do with Humanin, what they expect, and what goes wrong. The full account, including the negative reports, is below.
Animal and lab work, not yet tested in people
Real results, but from animals or cells, not people. What works in a mouse often does not work the same way in a person. Nobody can patent this, so nobody would ever earn back the cost of a study in people. That is usually why there is none. The record on this one is set out below.
- Memory and thinking1 animal or lab study
- Living longer1 animal or lab study
30 of the 36 indexed goals have no study of any kind behind Humanin
No study in people, animals or cells on this page reports a result for these. That does not prove Humanin does nothing for them. It does mean anything you have heard about Humanin and one of these did not come from a study cited here.
Show full evidence
What is Humanin?
Humanin is a tiny peptide made from mitochondrial DNA. In people it has been watched, not given. It falls with age, runs high in the children of people who lived to 100, tracks with heart and blood sugar risk, and rises in the muscle of people with one mitochondrial disease. No study has given it to people as a drug.
Humanin is a chain of 24 amino acids. Its recipe sits in the DNA of mitochondria, the cell's power plants.
Everything known about it in people comes from watching, not giving. But it is real, and it comes from named groups of people. Humanin in the blood falls with age. It is clearly higher in the grown children of people who lived to 100 than in others their age. It is lower in people whose fasting blood sugar has started to drift up. In people on kidney dialysis, both very low and very high levels went with more heart problems and deaths. In muscle from people with MELAS, a mitochondrial disease, there is more of it, not less. Researchers read that as the body reacting to energy stress. No study has measured what happens when a person is given humanin or a drug based on it.
It was found in 2001. In a dish, it stopped brain cells dying from Alzheimer's genes and from amyloid-beta, the sticky protein linked to Alzheimer's. In rats, it made the whole body respond better to insulin, through a signal in the brain. In worms, making more of it helped them live longer. In mice, a lab-made version improved metabolic health and lowered swelling markers.
How does Humanin work?
Humanin switches on signals that protect cells and stop them self-destructing. Part of this is by binding two proteins, IGFBP-3 and Bax. It changes how the body responds to insulin through a signal in the brain called STAT-3. It also acts directly on how cells take up sugar and how the liver releases sugar. In a dish and in animals, it protects against harmful oxygen molecules and other damage linked to Alzheimer's disease. No study has measured how it moves through the human body or what it binds to in people.
What have studies in people found about Humanin?
No published study has given humanin, or a drug based on it, to a person. What exists is a steady set of findings from watching people. Humanin in the blood falls with age, is higher in people whose parents lived to 100, tracks with blood sugar and heart risk, and rises in the muscle of people with a mitochondrial disease.
- Exercise, 75 pro athletes against 30 people who do not train (Alser and others, 2022): pro athletes had more humanin at rest than people who do not train. But within the athletes, the hardest endurance athletes had less humanin than the rest.
- Heart risk, 94 people on kidney dialysis followed for 30 months (Bolignano and others, 2024): both very low and very high humanin in the blood went with more deaths or heart problems than levels in the middle. The risk curve was U shaped, not a straight line.
- Early blood sugar problems, a diabetes screening clinic, 23 people with high fasting blood sugar against 58 with normal levels (Voigt and Jelinek 2016): humanin in the blood was lower in the high sugar group (124.3 against 204.8 pg/mL).
- Children of people who lived to 100, an Ashkenazi Jewish long-life study, 18 such children against 19 people of the same age (Yen and others, 2020): humanin in the blood was clearly higher in the children. This group is already known to have less disease and to die later. It does not show humanin causes long life.
- Exercise, 30 adults assigned to one endurance session, one weight session or rest (von Walden and others, 2021): humanin in the blood clearly rose after endurance exercise. This is the steadiest short-term finding in the human data on this page.
- Alzheimer's disease, spinal fluid, 4 patients against 3 people without it (same 2020 study): humanin was lower in Alzheimer's. The group is far too small to draw a conclusion from on its own.
- Age, blood samples from people at one point in time (Muzumdar and others, 2009): humanin in the blood was lower in older people. The paper does not say how many people were tested or their ages.
- MELAS, a mitochondrial disease, muscle samples (Kariya and others, 2005): muscle fibres and small arteries in people with MELAS had more humanin. Researchers read this as the body reacting to tissue short of energy. That is the opposite direction from the age and disease links above.
What this does not tell you: Every point above is a link found by watching, not a test of giving it. None of these studies gave a person humanin or a drug based on it. So none can show that raising humanin brings the benefits linked to naturally higher levels. Humanin acts like a stress signal in the body. It rises in MELAS muscle and after exercise, and falls with age and with rising blood sugar. That does not predict what a fixed dose from a shot would do. Several groups are very small: 4 Alzheimer's patients, and 18 and 19 in the long-life family groups. The dialysis study is a single small first study with a U-shaped result nobody has repeated. No study has measured how humanin moves through the body, a dose, or its safety in a healthy person given it. No study with a comparison group has tested humanin in any human condition.
What do people who took Humanin report?
This is what real people say happened to them, good and bad. Nobody measured it. A report cannot tell a real effect from the lift people get just from expecting it to work, from a diet or training change made at the same time, or from what was really in the vial. We still put it near the top. It is the next best thing to a study in people: what happens when real people use it, including what goes wrong.
- Humanin is talked about and sold as a do-it-yourself peptide far less than BPC-157, TB-500 or MOTS-c. The clearest public account is one self-experiment by a blogger writing as 'KenkoHacks'. It is repeated on several peptide seller sites, and we could not check it. The person took about 1 mg twice a day for 15 days, scaled to a 58 kg body weight and based on humanin's short reported half-life. They described a 'sense of calm and wellness' and no side effects.
- Seller and dosing guide sites describe humanin as usually well tolerated, compared with peptides that change hormones, since it is a natural signal and not a hormone copy. The problems they name most are irritation where the needle went in, headache, mild stomach upset, and light-headedness in people who have not eaten. None of these reports come from a study.
- Because humanin is rarely sold or discussed on its own, there is little talk of how long people take it, what they stack it with, or of people who felt nothing. The user record here is too thin to describe with any confidence. This page does not treat the one self-experiment above as standing for anyone but that person.
Sources: A blog self-experiment attributed to 'KenkoHacks', accessible only through its citation on secondary peptide-vendor sites (Jay Campbell, Swolverine, PeptidesExplorer); those same vendor and dosing-guide sites for the general side-effect categories described above. Reddit and the peptide and bodybuilding forums checked for the MOTS-c entry in this dataset (iSARMS, eroids) returned no substantive humanin-specific threads at the time of this review, so this section is deliberately thin rather than padded with unrelated material.
The state of the research
Humanin is a 24 amino acid recipe in mitochondrial DNA, published in 2001. Like other peptides from mitochondrial DNA, it can barely be patented. So no company has an obvious reason to pay for studies in people, and nothing like a company-paid study exists for humanin itself. Lab-made versions such as HNG have been patented and tested in animals. The biology is well mapped. The discovery ran in PNAS, the metabolism work in PLoS One, and the lifespan work in a 2020 paper covering worms, mice, naked mole-rats and people. That 2020 paper includes the long-life family and Alzheimer's findings above. What is missing is a study in people with a comparison group, not the science.
The human findings from watching people are steady, and they come from named groups. Many peptides in this category cannot say that much. But steady findings from watching are not the same as a test, and there is a clear warning in this very field. In 2015, a MOTS-c gene variant was put forward to explain long life in Japan, based on a 96-person study. In 2021, a study of 736 people aged 100 or more found no such link, which reversed the idea. Findings about the body's own levels or genes often fail to predict what a drug does once it is tested. The clearest example in heart medicine is HDL, the good cholesterol. Higher HDL goes with fewer heart problems across large population and gene studies. But drugs that raised HDL, including torcetrapib and dalcetrapib, did not cut heart attacks or strokes in proper studies, and torcetrapib raised deaths. Humanin's own data add a twist: more is not simply better. It falls with age and with rising blood sugar, but rises in MELAS muscle and after exercise. The biggest study of illness and death so far, in people on dialysis, found a U-shaped link with risk, not a straight line. A peptide that works as a stress signal that depends on the situation does not turn easily into a fixed dose.
Unlike BPC-157, TB-500 and MOTS-c, humanin was not put forward to the FDA's compounding advisory panel at its July 2026 meeting. So it was not part of that debate and has no panel vote to report.
The evidence, in charts
Fig. 1a · how many people
147people, across 3 studies in people cited here
| Study | People | Share |
|---|---|---|
| Journal of Nephrology 2024 | 94 | 64% |
| Journal of Applied Physiology 2021 | 30 | 20% |
| Physiological Reports 2016 | 23 | 16% |
One study holds 64% of these people, so the total rests more on one study than its size suggests. Counts are the number of people each study on this page says it signed up. That includes studies that only watched people and gave nobody the compound. 2 more studies in people give no headcount and are not counted here. Studies still signing people up are left out, and only studies cited on this page are counted.
Fig. 1b · evidence mix
5 of 9 sources here are studies in people. The rest are not.
- Study in people · done in people556%
- Animal study · done in animals222%
- Lab (cells in a dish) · cells or tissue111%
- Review of studies · sums up other studies111%
Counted from the list of sources on this page. It counts only what we cite, so there may be more studies out there. A review counts once, however many studies it sums up.
Fig. 2 · evidence over time
The studies cover 9 different years, 2001 to 2024, counted from the list of sources on this page.
Fig. 3 · legal status at a glance
US
Not approved
UK
Not approved
AU
Not approved
CA
Not approved
Not approved in any of the four countries shown. This is what the law says, not a verdict on the science. See Legal status below for the full text and any notes.
Fig. 4 · how much does what
Nobody has tested different amounts in people
This chart would show how the effect changes as the amount goes up. For this compound, nobody has measured that in people. So we leave it empty. We will not borrow an animal chart and pretend it works the same in people.
Fig. 5 · what the molecule is
- Kind of compound
- Peptide
- Molecule weight
- ~2,687 Da
- Half-life
- Stated in words, not a numbersee the exact wording below
- Chain length
- None on file
No amino acid sequence is on file for Humanin, so none is drawn rather than guessed from a name.
The studies we cite
- Study in people2005Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent
In a severe mitochondrial disease, the body made more humanin, not less. Muscle samples were taken from patients with MELAS, an inherited condition that starves cells of energy. The damaged fibres and the small blood vessels around them carried extra humanin. The authors read this as the body pushing back against the damage. Nobody was given anything, and no symptom was measured. So this says humanin responds to stress in a diseased muscle. It does not say that taking humanin would help.
Muscle biopsies from patients with the mitochondrial disease MELAS: humanin expression was increased, not decreased, in ragged-red fibers and small arteries, interpreted as a compensatory response to energy-deficient, high-oxidative-stress fibers.
- Study in people2016Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress
People whose fasting blood sugar had started to drift up carried less humanin. Twenty-three of them were compared with fifty-eight people whose blood sugar was normal, at a clinic screening for diabetes complications. Nobody was given anything. Humanin in the blood was about two fifths lower in the higher sugar group, at 124.3 against 204.8 units. The authors think the body's protective response has weakened. Twenty-three people is a very small group, and one measurement cannot show what caused what.
Diabetes complications screening clinic: plasma humanin was significantly lower in 23 people with impaired fasting glucose than in 58 controls (124.3 vs 204.8 pg/mL, p=.0001), interpreted by the authors as a blunted adaptive response.
- Study in people2024Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study
More humanin is not better. Ninety-four people on kidney dialysis were followed for two and a half years. Nobody was given anything. Those with the lowest levels and those with the highest were both more likely to die or have a heart problem than those in the middle, by between two and a half and nearly six times. The risk curve is U shaped. Any claim that raising humanin protects you runs into the upper end of that curve. Ninety-four people is a small group.
Prospective study of 94 hemodialysis patients followed 30 months: both very low and very high circulating humanin carried higher hazard ratios (2.5 to 5.8) for death or cardiovascular events than mid-range levels, a U-shaped rather than linear relationship.
- Study in people2022The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes
Athletes carried more humanin than people who do not train, but more training did not mean more humanin. Seventy-five professional athletes were compared with thirty sedentary adults. Nobody was given anything. The athletes had higher levels overall. Inside the athlete group the pattern reversed, because the hardest endurance specialists had less humanin than teammates of the same age and sex. If humanin simply rose with fitness, that reversal should not happen. Groups who differ in many ways cannot show what caused the difference.
30 sedentary controls versus 75 professional athletes: professional athletes had higher serum humanin than sedentary controls, but within the athlete group, high-endurance athletes had lower humanin than low/moderate-endurance athletes of the same age and sex.
- Study in people2021Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans
A single endurance session raises humanin in the blood. Lifting weights does not. Thirty adults were assigned to one bout of endurance exercise, one bout of weight training, or nothing. Humanin went up only after the endurance session. It did not track how fit anyone was, measured by running capacity, by strength, or by the amount of mitochondrial DNA in their muscle. So the rise looks like a short term response to that one effort. Nobody was followed to see whether it mattered.
30 adults randomized to endurance exercise, resistance exercise or control: circulating humanin rose significantly after a single bout of endurance exercise but not resistance exercise, and did not correlate with fitness (VO2max, strength or muscle mtDNA copy number).
- Review of studies2013The emerging role of the mitochondrial-derived peptide humanin in stress resistance
A review of how humanin protects cells, stops them self-destructing and affects metabolism. Data on giving it to people as a treatment are still thin.
Review of humanin's cytoprotective, anti-apoptotic and metabolic signaling; human therapeutic data remain limited.
- Animal study2009Humanin: a novel central regulator of peripheral insulin action
In rats, humanin given to the brain or the body made the whole body respond better to insulin, through a signal in the brain. Humanin levels fell with age in rodents. In a group of people it also fell with age, but the paper does not say how many people.
Central or peripheral humanin improved whole-body insulin sensitivity in rats via hypothalamic STAT-3; humanin levels fell with age in rodents and, in a cross-sectional human sample, in humans (exact cohort size not reported in the published methods).
- Animal study2020The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
In worms, making more humanin helped them live longer. In mice, a lab-made version improved metabolic health. In people, humanin in the blood was higher in 18 grown children of people who lived to 100 than in 19 people of the same age. In spinal fluid from just 7 people, it was lower in those with Alzheimer's.
Humanin overexpression extended lifespan in C. elegans and an analogue improved metabolic healthspan in mice. In a human Ashkenazi Jewish cohort, circulating humanin was significantly higher in the 18 adult offspring of centenarians than in 19 age-matched controls (p<.05); in a 4-person CSF sample, humanin was lower in Alzheimer's patients than 3 controls (p<.05, very small n).
- Lab (cells in a dish)2001A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta
In a dish, the paper that found humanin, a short peptide that cells release. It stopped brain cells dying from Alzheimer's genes and from amyloid-beta, the sticky protein linked to Alzheimer's.
Discovery paper: humanin cDNA encodes a short secreted peptide that abolished neuronal death caused by familial Alzheimer's disease genes and amyloid-beta in cell culture.
Where to buy Humanin
36 sellers list Humanin in our latest read. They are ranked by trust score, then by archive rating, then by certificate tier, then by the lowest price per milligram. Archive evidence is counted before source-backed. Each path is out of 4, and the two are not added. A higher price does not raise the score. The letter is the certificate chip. 0 of them have a published certificate that names Humanin.
Some seller links may pay this site when you buy through them. A payment never changes a seller's tier or rank, and no seller has a say in any page.
| Seller | Trust score | Vial sizes | From, per mg | Certificate for Humanin | Seller link |
|---|---|---|---|---|---|
| Alpha Peptides | 80 StrongSource-backed 4 of 4. Archive evidence 2 of 4.A | 10 mg | $10.9 | None found for Humanin | View |
| Peptide Power US | 77 StrongSource-backed 4 of 4. Archive evidence 2 of 4.A | 10 mg | $13.5 | None found for Humanin | View |
| BioGenix Peptides | 75 StrongSource-backed 4 of 4. Archive evidence 2 of 4.A | 10 mg | $11.8 | None found for Humanin | View |
| Core Peptides | 75 StrongSource-backed 4 of 4. Archive evidence 2 of 4.A | 10 mg | $14.7 | None found for Humanin | View |
| Bulk Peptide Supply | 65 FairSource-backed 4 of 4. Archive evidence 2 of 4.A | 10 mg | $4.75 | None found for Humanin | View |
| Peptide Plugs | 65 FairSource-backed 4 of 4. Archive evidence 2 of 4.A | 5 mg | $20.0 | None found for Humanin | View |
| PeptidePlugs | 65 FairSource-backed 4 of 4. Archive evidence 2 of 4.A | 5 mg | $20.0 | None found for Humanin | View |
| Limitless Bio-Tech | 52 FairSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $8.56 | None found for Humanin | View |
| Oasis Labs | 49 WeakSource-backed 3 of 4. Archive evidence 3 of 4.A | 10 mg | $12.2 | None found for Humanin | View |
| Biotech Peptides | 49 WeakSource-backed 3 of 4. Archive evidence 3 of 4.A | 10 mg | $14.0 | None found for Humanin | View |
| Research Purpose Labs | 49 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A | 10 mg | $8.00 | None found for Humanin | View |
| True Lab Peptides | 49 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A | 10 mg | $9.90 | None found for Humanin | View |
| Peptify Labs | 49 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A | 10 mg | $11.0 | None found for Humanin | View |
| Core Peptides Official | 49 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A | 10 mg | $13.5 | None found for Humanin | View |
| Luxe Peptides | 49 WeakSource-backed 3 of 4. Archive evidence 2 of 4.A | 10 mg | $13.9 | None found for Humanin | View |
| Apexlab | 49 WeakSource-backed 2 of 4. Archive evidence 2 of 4.B | 10 mg | $13.3 | None found for Humanin | View |
| Peptide Shop A | 49 WeakSource-backed 2 of 4. Archive evidence 2 of 4.B | 10 mg | $14.0 | None found for Humanin | View |
| Cenexa Labs | 49 WeakSource-backed 2 of 4. Archive evidence 2 of 4.B | 10 mg | $15.0 | None found for Humanin | View |
| Pure Peptide Factory | 48 WeakSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $10.0 | None found for Humanin | View |
| Solution Peptides | 48 WeakSource-backed 1 of 4. Archive evidence 0 of 4.C | 10 mg | $6.90 | None found for Humanin | View |
| Direct SARMS | 40 WeakSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $5.31 | None found for Humanin | View |
| Peptide Pros | 39 WeakSource-backed 4 of 4. Archive evidence 1 of 4.B | 5 mg | $9.68 | None found for Humanin | View |
| Peptides World | 39 WeakSource-backed 4 of 4. Archive evidence 1 of 4.B | 10 mg | $12.0 | None found for Humanin | View |
| Canlab International | 37 WeakSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $14.5 | None found for Humanin | View |
| Limitless Biotech ST | 36 WeakSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $14.7 | None found for Humanin | View |
| Lejian Biotech Peptide | 35 WeakSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $13.7 | None found for Humanin | View |
| LabRat Peptides | 28 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $6.50 | None found for Humanin | View |
| Peptides Sales | 28 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C | 5 mg | $9.00 | None found for Humanin | View |
| Boston Molecules | 28 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $81.0 | None found for Humanin | View |
| Peptide Science LLC | 25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $13.0 | None found for Humanin | View |
| Huaian Hanyou Peptide | 25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $13.7 | None found for Humanin | View |
| MJA Peptides | 25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $13.7 | None found for Humanin | View |
| ZL Peptides | 25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $13.7 | None found for Humanin | View |
| USA Peptide Sciences | 25 InsufficientSource-backed 1 of 4. Archive evidence 1 of 4.C | 10 mg | $15.5 | None found for Humanin | View |
| Pure Health Peptides | 25 InsufficientSource-backed 1 of 4. Archive evidence 0 of 4.C | 5 mg, 10 mg | $8.90 | None found for Humanin | View |
| RUO | 18 InsufficientSource-backed 3 of 4. Archive evidence 2 of 4.Letter withheld | 10 mg | $4.60 | None found for Humanin | View |
- LC Lab-confirmed: the issuing laboratory echoed this certificate back
- A Current certificate, independent laboratory named, laboratory not yet checked
- B Certificate published, but no laboratory link, older than a year, or the laboratory did not recognise the published lookup
- C No certificate could be read
Every listing and vial size for Humanin · How the trust score is counted
Sellers named on the price pages are ranked by certificate tier, then price, and any affiliate income is disclosed there. Naming a seller is not a recommendation to buy or use anything.
Common questions
Has Humanin been tested in people?
Yes. 30 people given it across 1 completed trial cited here, 0 of which found nothing. Humanin is a tiny peptide made from mitochondrial DNA. In people it has been watched, not given. It falls with age, runs high in the children of people who lived to 100, tracks with heart and blood sugar risk, and rises in the muscle of people with one mitochondrial disease. No study has given it to people as a drug.
What is the Humanin dosage?
No human dose established. Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose. 1 completed trial, 30 people given it
Is Humanin FDA-approved?
Not FDA-approved; investigational. Unlike BPC-157, TB-500 and MOTS-c, nobody had put it forward for the FDA's list of ingredients pharmacies may use (the 503A bulks list) as of the July 2026 Pharmacy Compounding Advisory Committee meeting
Is humanin proven to work in humans?
No. No study with a comparison group has given humanin, or a drug based on it, to a person, so nothing about its effects in people is proven. What exists is a steady set of findings from watching people. Humanin in the blood falls with age. It is clearly higher in the grown children of people who lived to 100. It is lower in people whose fasting blood sugar has started to rise. In people on kidney dialysis, both low and high levels went with more heart risk. It rises in the muscle of people with the mitochondrial disease MELAS. These are links in real people, not proof that giving someone humanin helps.
Why is humanin linked to longevity?
Humanin in the blood is clearly higher in the grown children of people who lived to 100 than in others their age. That group is known to have less disease and to die later. It also falls with age in general. That is a real link from a named group of people, not a made-up claim. But it does not show humanin causes long life, or that raising it would make anyone live longer. A similar-sounding gene idea for the related peptide MOTS-c was tested in a bigger group and did not hold up.
Does humanin decline with age, and does that mean more is better?
It does fall with age, and it is also lower in people whose fasting blood sugar has started to rise. But the same peptide is higher, not lower, in the muscle of people with the mitochondrial disease MELAS, and after a session of endurance exercise. The biggest study of illness and death so far, in people on kidney dialysis, found that both very low and very high levels carried more risk than levels in the middle. That looks like a stress signal that depends on the situation, not a simple marker where higher is always better. That is one reason the body's own level cannot predict what a fixed dose from a shot would do.
Latest reading on Humanin
Blog posts about Humanin, newest first.