How does humanin work?
Humanin is a 24-amino-acid peptide made from the DNA inside mitochondria. This site's profile gives its molecular weight as about 2,687 daltons. It is listed as leaving the body quickly (a short half-life). No published study has given humanin, or a version of it, to a person. So that page has no measurement in people of how the body handles it or what it latches onto. What exists only watched people. Blood humanin drops with age. It was higher in 18 adult children of centenarians (very long-lived people) than in 19 people of the same age. Blood humanin was 124.3 versus 204.8 pg/mL in 23 people with high fasting blood sugar versus 58 people without it. In 94 people on kidney dialysis, risk was highest at both low and high levels. And blood humanin rose after one endurance workout in 30 adults. Work in cells and animals describes cell-protecting signals through two proteins (IGFBP-3 and Bax), and effects on insulin through a brain signal (STAT-3) in rats. Those findings do not transfer into a counted human drug effect. This FAQ does not invent a human mechanism. Full record at /compounds/humanin.
Studies in people from the compound pages this answer belongs to
- Humanin
- Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent 2005 PMID 15759134
- Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress 2016 PMID 27173674
- Unbalanced circulating Humanin levels and cardiovascular risk in chronic hemodialysis patients: a pilot, prospective study 2024 PMID 39102184
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of immune and longevity peptides. Thymosin alpha-1, thymalin, epitalon, MOTS-c, humanin, and the bioregulator family.