How does thymosin alpha 1 work?
Thymosin alpha-1 is described as adjusting T cells (immune cells) and the body's first-line immune defense. This site's profile cites a review of how it signals through Toll-like receptors, alarm sensors on certain immune cells. The body clears half of it in about 2 hours. Its molecular weight is 3,108 daltons. The largest study in people on this site is the TESTS sepsis study, in 1,106 adults: 23.4% died within 28 days, versus 24.1% on a dummy treatment. A 98-person hepatitis B study found the virus was fully cleared at 18 months in 40.6% after a 26-week course, versus 9.4% of people who were not treated. Those are hepatitis and sepsis results, not a general result for how it works in anyone. Its approval as Zadaxin in more than 30 countries is a fact about hepatitis, not a US approval. This FAQ does not invent a dose. Full record at /compounds/thymosin-alpha-1.
Studies in people from the compound pages this answer belongs to
- Thymosin Alpha-1
- Efficacy of thymosin alpha1 in patients with chronic hepatitis B: a randomized, controlled trial 1998 PMID 9581695
- The efficacy and safety of thymosin alpha 1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial 2025 PMID 39814420
- The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial 2013 PMID 23327199
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of immune and longevity peptides. Thymosin alpha-1, thymalin, epitalon, MOTS-c, humanin, and the bioregulator family.