How does NMN work?

NMN is nicotinamide mononucleotide. The body turns it into NAD+, a key helper molecule for making energy, through the salvage pathway (its recycling route). This site's profile lists a molecular weight of 334.2 daltons and says it leaves the body quickly. It is not an approved drug. In 2022 the FDA ruled it out as a US dietary supplement, because it had already been cleared for testing as a drug. Its US supplement status is still disputed. Findings in people on this site: a 60-day study in 80 adults raised blood NAD and slightly improved how far they could walk in six minutes, with a measure of insulin resistance (HOMA-IR) unchanged. In 30 overweight or obese adults, MIB-626, a pharmacy-grade NMN tablet, for 28 days led to 1.9 kg more weight loss than a dummy pill, with lower bottom blood pressure number and lower LDL cholesterol. Muscle strength, fitness, and insulin response did not differ. The maker paid for that study. A 10-week study in overweight or obese women past menopause with prediabetes found their muscles responded better to insulin than on a dummy pill, while other metabolic measures did not change. In 14 older men with diabetes and weak physical performance, average age 81.1, grip and walking speed were no different from the comparison group over 24 weeks. Teijin paid for that study. A rise in blood NAD is not a real-world aging result. No study on this page has tested whether NMN slows aging in a person. Twelve months of oral NMN in aging mice improved insulin response, energy use, activity, and eye function, with no obvious harm. Those animal findings do not transfer into a counted human ageing result. This FAQ does not invent a dose. Full record at /compounds/nmn.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of immune and longevity peptides. Thymosin alpha-1, thymalin, epitalon, MOTS-c, humanin, and the bioregulator family.