How does FOXO4-DRI work?

FOXO4-DRI is a lab-designed peptide meant to clear out 'zombie' cells (senescent cells, old cells that stop dividing but do not die). This site's profile says it breaks up the FOXO4-p53 link only in those cells. That frees p53 to make those cells self-destruct while healthy cells are spared. It is listed as leaving the body quickly (a short half-life). Its molecular weight is about 5,200 daltons. It is not FDA approved. This site's review found no human clinical trial. How it works in people has not been measured. In mice, the 2017 Cell paper reported better fitness, thicker fur, and better kidney function in mice bred to age fast and in naturally old mice. In old mice, a 2020 study found it made zombie testosterone-making cells (Leydig cells) self-destruct and improved testosterone output. Those animal findings do not transfer into a counted human senolytic result. This FAQ does not invent a human mechanism. Full record at /compounds/foxo4-dri.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of immune and longevity peptides. Thymosin alpha-1, thymalin, epitalon, MOTS-c, humanin, and the bioregulator family.