How does rapamycin work?

Rapamycin, also called sirolimus, blocks the mTOR pathway, a growth switch inside cells. This site's profile says that copies parts of eating less, and boosts the cell's clean-up and upkeep (autophagy). The body clears half of it in about 60 hours. Its molecular weight is 914.2 daltons. It is FDA approved as Rapamune to prevent the body from rejecting a transplant. Using it for longevity is off-label and still experimental. PEARL found 48 weeks of low-dose rapamycin, taken on and off, was fairly safe in normally aging adults. Lean mass and pain improved in women on 10 mg, one finding among many measures. Kraig 2018 put 25 generally healthy adults aged 70 to 95 on 1 mg daily or a dummy pill. 11 on rapamycin and 14 on the dummy pill finished at least 8 weeks. That was a small safety test, not a lifespan study. No careful study has tested whether rapamycin extends human life. In mice with mixed genes, rapamycin given late in life extended lifespan by 14% in females and 9% in males, measured at the point where 90% had died. That is a mouse finding and it stays one. This FAQ does not invent a dose. Full record at /compounds/rapamycin.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

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