Does anything actually slow ageing?

The polyphenol behind the sirtuin era of longevity research and one of the most heavily trialled supplements in this dat...

A fibrinolytic enzyme from Bacillus subtilis natto fermentation with a genuinely large human trial record for a suppleme...

A mitochondrial-derived peptide with a real human literature: a common East Asian genetic variant, circulating levels me...

A synthetic pineal tetrapeptide with more human data than its reputation suggests, including a 6 to 8 year observation o...

A mitochondrial-derived peptide with a genuine human observational record: it declines with age, runs high in children o...

An FDA-approved GHRH analogue that reduces visceral fat, now also studied for cognition in older adults at Alzheimer's r...

A calf-thymus peptide preparation used clinically in the Soviet Union and Russia since the 1980s, with a large Russian c...

A well-studied NAD+ precursor that reliably raises NAD+ in humans. Raising the molecule is proven; the mouse lifespan pr...

A glutathione precursor that is FDA-approved as a mucolytic and antidote for acetaminophen overdose, and studied more br...

A gut-derived compound that triggers mitophagy and has improved muscle function in older adults in human trials, one of...

An FDA-approved antidote for methemoglobinemia that biohackers take at low doses for mitochondrial energy and focus; the...

An investigational mitochondria-targeting peptide studied for rare mitochondrial disease and age-related organ decline.

The body's master intracellular antioxidant tripeptide, used to support redox balance, detoxification, and skin, with mi...

A direct NAD+ precursor studied for metabolic and physical-function benefits in aging, with early human trials and a con...

A natural protein that blocks myostatin and activin, studied largely through gene therapy for muscle growth and muscular...

A versatile antioxidant compound studied for diabetic nerve pain and metabolic health, sold as a supplement and used as...

A topical cosmetic peptide marketed as a 'Botox-like' wrinkle reducer that relaxes expression lines at the skin surface.

A common dietary flavonoid used as a senolytic, most notably paired with the drug dasatinib in human senescence trials.

An FDA-approved leukemia drug repurposed in research as a senolytic, most often combined with quercetin to clear senesce...

An FDA-approved mTOR inhibitor that extends lifespan in animals and is widely studied off-label at low, intermittent dos...

A combination of glycine and NAC studied in older adults for restoring glutathione and improving multiple markers of agi...

BioAge's brain-penetrant NLRP3 inhibitor that cut the inflammation marker hsCRP by a median 86% in two weeks in Phase 1,...

The most advanced senolytic in humans: an injected BCL-xL inhibitor that matched the biologic aflibercept on vision at m...

Rubedo's topical senolytic that met its Phase 1 safety endpoint in psoriasis, eczema and photo-aged skin, with collagen...

The first partial cellular reprogramming therapy in humans: Life Biosciences dosed the first patient in June 2026, deliv...

The 'anti-aging gene' protein whose blood levels track with longevity and cognition; a gene therapy (KLTO-202) is headin...

A central metabolic coenzyme marketed via IV and injectable forms for anti-aging and recovery, with declining levels in...

A short synthetic peptide bioregulator from the Khavinson group studied for brain protection and cognition.

A diet-derived antioxidant amino acid that accumulates in cells via a dedicated transporter, studied as a possible longe...

A natural polyamine that induces autophagy, linked in population studies to lower mortality and studied for cardiovascul...

A plant flavonoid and leading natural senolytic. One mouse study reported extended lifespan; the multi-site programme bu...

A metabolite supplement studied for healthy aging. One mouse study reported longer life; the multi-site replication prog...

The first clinical drug from Retro Biosciences, the Sam Altman-backed longevity company: an oral, brain-penetrant molecu...

An oral AMPK activator with one 28-day human pilot in type 2 diabetes and recent mouse data, now sold as a research chem...

A mitochondria-targeted antioxidant registered in Russia as an eye drop for dry eye; rodent lifespan claims come from a...

An experimental senolytic peptide that selectively triggers death of senescent cells in animal studies.

A circulating TGF-beta family factor at the center of young-blood rejuvenation research, with contested and preliminary...

A zinc-dependent thymic hormone studied for immune regulation, inflammation, and pain, mostly in preclinical work.

A synthetic dipeptide from the Khavinson bioregulator research studied for immune and anti-aging effects.

A synthetic peptide bioregulator studied in Russian research for cardiovascular tissue and age-related heart changes.

An experimental 'exercise mimetic' that activates energy-metabolism pathways in animals, with no human data yet.

A daily pill for senior dogs that could become the first drug the FDA has ever approved for extending lifespan; the agen...

A Salk Institute fisetin derivative described as a 'geroneuroprotector' that improved memory and reduced brain lipid dam...

A natural NAD+ precursor found in coffee and fenugreek that improved muscle function in aged mice and worms and is lower...

A Khavinson tetrapeptide sold for liver and gut 'bioregulation'; preclinical work from one group only.