SLU-PP-332 dosage and evidence

What is SLU-PP-332?

How does SLU-PP-332 work?

It turns on the ERR switches. That boosts how mitochondria burn fuel, copying changes that endurance training brings.

What do people who took SLU-PP-332 report?

This is what real people say happened to them, good and bad. Nobody measured it. A report cannot tell a real effect from the lift people get just from expecting it to work, from a diet or training change made at the same time, or from what was really in the vial. We still put it near the top. It is the next best thing to a study in people: what happens when real people use it, including what goes wrong.

• The discussion is mostly an unresolved argument about dose, and the range in dispute spans more than an order of magnitude. Amounts of a few hundred micrograms up to about 1 mg circulate as sensible, while vendors sell tablets of around 20 mg, and nobody in the threads can reconcile the two.
• Underneath that sits an absorption problem people raise repeatedly, citing the chemist who first made the compound. Absorption by mouth is described as near zero, and the animal dose scaled to a person comes out at hundreds of milligrams twice a day, which people use to argue that most of what is being sold cannot do anything by mouth.
• Reports split accordingly. People describe feeling nothing at all at a milligram, while others describe strong stimulation at smaller amounts, and posters themselves read that split as evidence that products differ rather than that people differ.
• Where effects are described they are heavy sweating, better endurance in conditioning work and steadier glucose, almost always by people running several other compounds at the same time, which nothing in the threads separates.
• Blunt scepticism runs through it, with the whole recent category described by some as snake oil, and no one presenting bloodwork or measurements to settle the question.

Sources: MESO-Rx dosing and high dose threads, reached through site-restricted search extracts because that board returned empty page bodies to direct fetch from this environment in September 2026. Nothing above is attributed to any specific post and no post is reproduced.

The evidence, in charts

The studies we cite

• Animal study2023
  Synthetic ERR alpha/beta/gamma agonist induces an ERR alpha-dependent acute aerobic exercise response and enhances exercise capacity

  In mice: SLU-PP-332 switched on the same muscle genes that aerobic exercise turns on, and the mice could run longer.

  SLU-PP-332 triggered an aerobic-exercise-like transcriptional program in muscle and increased running endurance in mice.

  PMID 36988910 ACS Chemical Biology
• Animal study2024
  A synthetic ERR agonist alleviates metabolic syndrome

  In fat mice, and mice bred to be obese, SLU-PP-332 improved measures of metabolism without any exercise.

  In diet-induced obese and ob/ob mice, SLU-PP-332 improved metabolic parameters without exercise.

  PMID 37739806 Journal of Pharmacology and Experimental Therapeutics