Bone and joints
What is real for bone density and joints?
Osteoporosis has genuine approved drugs with fracture endpoints. The joint and cartilage claims mostly do not have the same backing, and the difference is stated on each page.
6 compounds studied for this · 3 with three or more human studies cited · 0 with none
Three or more human studies cited 3
The deepest human evidence on this site for this goal. That is a statement about how much has been measured, not about whether it will work for you.
Resveratrol
14 citedThe polyphenol behind the sirtuin era of longevity research and one of the most heavily trialled supplements in this dat...
LongevityMK-677
3 citedA non-peptide, orally active ghrelin receptor agonist that raises growth hormone and IGF-1. Completed but did not pass P...
Growth HormoneLorecivivint
3 citedAn injected Wnt-pathway small molecule for knee osteoarthritis whose two published Phase 3 pain trials both missed their...
Healing & RecoveryOne or two human studies cited 3
Something has been run in people, and it is a thin base. The count is on each card so you can see exactly how thin.
Teriparatide
2 citedAn FDA-approved bone-building peptide, a fragment of parathyroid hormone used for severe osteoporosis.
HormoneAbaloparatide
2 citedAn FDA-approved bone-building peptide analogue of parathyroid hormone-related protein for postmenopausal osteoporosis.
HormoneCalcitonin
1 citedA hormone that lowers blood calcium, FDA-approved (as salmon calcitonin) for osteoporosis, Paget's disease, and high cal...
HormoneWhat the number counts, exactly
The figure on each card is the number of citations on that compound’s page whose study type is Human. It is counted the same mechanical way for all 192 compounds and you can check any of it by opening the profile and reading the citation list, which is the whole point of publishing a number at all.
It is a count of what we cite, not a claim about how much research exists. A compound with three human studies here may have thirty in the literature, and the honest thing to say is that we have read and listed three. It is also not a quality score: three small open-label studies count the same as three randomised trials, so the tiers tell you how much was measured in people and the page itself tells you how well.