Heart and circulation
What has been shown to lower cardiovascular risk?
The area with the hardest endpoints on the whole site. Cardiovascular trials count events, not markers, which makes the evidence here unusually trustworthy when it exists.
10 compounds studied for this · 2 with three or more human studies cited · 1 with none
Three or more human studies cited 2
The deepest human evidence on this site for this goal. That is a statement about how much has been measured, not about whether it will work for you.
Nattokinase
13 citedA fibrinolytic enzyme from Bacillus subtilis natto fermentation with a genuinely large human trial record for a suppleme...
LongevitySemaglutide
5 citedA long-acting GLP-1 receptor agonist approved for type 2 diabetes and chronic weight management, with proven cardiovascu...
MetabolicOne or two human studies cited 7
Something has been run in people, and it is a thin base. The count is on each card so you can see exactly how thin.
Liraglutide
2 citedA once-daily GLP-1 receptor agonist and the first GLP-1 approved specifically for obesity, with proven cardiovascular be...
MetabolicDulaglutide
2 citedA once-weekly GLP-1 receptor agonist for type 2 diabetes with demonstrated cardiovascular risk reduction.
MetabolicElamipretide
2 citedAn investigational mitochondria-targeting peptide studied for rare mitochondrial disease and age-related organ decline.
Anti-agingEfpeglenatide
2 citedAn investigational long-acting GLP-1 agonist that showed cardiovascular and kidney benefits in a large outcomes trial.
MetabolicVasopressin
2 citedThe natural water-retention hormone, FDA-approved as a drug to raise blood pressure in critically ill patients.
HormoneBGE-102
2 citedBioAge's brain-penetrant NLRP3 inhibitor that cut the inflammation marker hsCRP by a median 86% in two weeks in Phase 1,...
LongevitySpermidine
1 citedA natural polyamine that induces autophagy, linked in population studies to lower mortality and studied for cardiovascul...
LongevityNo human study cited here 1
Studied in other species or in cell culture, or studied in people for something else entirely. Listed rather than hidden, because knowing a thing has not been tested in a person is the useful part.
What the number counts, exactly
The figure on each card is the number of citations on that compound’s page whose study type is Human. It is counted the same mechanical way for all 192 compounds and you can check any of it by opening the profile and reading the citation list, which is the whole point of publishing a number at all.
It is a count of what we cite, not a claim about how much research exists. A compound with three human studies here may have thirty in the literature, and the honest thing to say is that we have read and listed three. It is also not a quality score: three small open-label studies count the same as three randomised trials, so the tiers tell you how much was measured in people and the page itself tells you how well.