Dihexa dosage and evidence

What is Dihexa?

How does Dihexa work?

It boosts hepatocyte growth factor and its receptor, c-Met. That drives the growth of new connections between brain cells.

What do people who took Dihexa report?

This is what real people say happened to them, good and bad. Nobody measured it. A report cannot tell a real effect from the lift people get just from expecting it to work, from a diet or training change made at the same time, or from what was really in the vial. We still put it near the top. It is the next best thing to a study in people: what happens when real people use it, including what goes wrong.

• Used topically in DMSO rather than injected or swallowed, and the solvent is as much the subject as the compound. People describe dissolving a quantity of powder into a fixed volume of solvent and applying a measured amount to the forearms every second evening, with the commonly cited active amount in the low tens of milligrams.
• The solvent is described as causing intense itching for roughly a quarter of an hour after application, along with the taste and breath DMSO is known for. A repeated warning is that the compound drops out of solution if water gets into it.
• The effects described are verbal fluency, social confidence and vivid dreaming rather than raw processing, and are usually described as noticeable but not dramatic.
• The negative raised most often is a mounting attention deficit that builds with continued use, with around four weeks mentioned as the point where it becomes a problem, and irritability on non-dosing days.
• Product authenticity is the dominant practical concern. At least one batch bought through a consumer marketplace was reported as failing HPLC testing outright, and product arriving in unmarked bags rather than sealed vials is described as normal for this compound rather than as a warning sign.
• The number of people writing at length about it is small and the same few accounts are referred back to across threads, so the apparent volume of discussion overstates how many independent reports actually exist.

Sources: Brain Health and Mental Health threads on LongeCity, including a summary-of-reports thread and a thread devoted to whether a particular account was genuine, found by site-restricted search and read directly, September 2026. Nothing above is attributed to any specific post and no post is reproduced.

The evidence, in charts

The studies we cite

• Review of studies2015
  The brain hepatocyte growth factor/c-Met receptor system: a new target for the treatment of Alzheimer's disease

  A review by the people who made dihexa. It describes how dihexa boosts HGF and c-Met and grows new branches and connections on brain cells in animals. There are no studies in people.

  Review by the developers describing dihexa as an HGF/c-Met potentiator that induces dendritic arborization and synaptogenesis in animal models; no human trials.

  PMID 25649658 Journal of Alzheimer's Disease
• Animal study2013
  Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents

  In rats, the paper that first described dihexa. It could be taken by mouth and got into the brain. It reversed memory loss caused by a drug and grew new connections in the brain's memory center. The journal put a formal warning, an Expression of Concern, on this paper in 2021.

  Introduced dihexa, an orally active, blood-brain-barrier-permeant AngIV analogue that reversed scopolamine-induced memory deficits and increased hippocampal synaptogenesis in rats. The journal issued an Expression of Concern for this paper in 2021.

  PMID 23055539 Journal of Pharmacology and Experimental Therapeutics