Trodusquemine dosage and evidence
Written by Aaron CuhaReviewed Sep 2026
The short answer
Trodusquemine is a compound first found in dogfish sharks. It blocks an enzyme called PTP1B. It regrew heart tissue in zebrafish and mice, and made fat mice lose fat only. Early human trials never published any results on whether it works.
Evidence grade for Trodusquemine: Animal or lab only. The rule: only animal or lab studies on this page. No study in people yet. The sum on this page: 2 animal studies, no human study. A grade counts how much has been done to people, not whether it works.
- People given it
- 0
- Human studies
- 0
- Found nothing
- 0
Dose
No human dose established
No published study on this page has given this compound to people and reported a result.
2 animal studies, no human study
4 effects reported, 3 unwanted, 1 wanted, by people using it, not a trial
Goal pages: Fat loss and metabolism
In plain English
In plain English, from Aaron
This is how I would explain it to a friend. The evidence, with the numbers, is further down the page.
Trodusquemine is a compound first found in dogfish sharks. It blocks an enzyme that dampens insulin and hunger signals. In animals it melted fat and helped hearts regrow. Early human studies were run years ago, and no results on benefit were ever published.
What people take it for
- Fat loss.
- Healing the heart or other tissue after injury.
What studies in people showed
There are no published human results on benefit. Early human studies in obesity and cancer happened years ago. In fat mice on a rich diet, weight loss came only from fat. In zebrafish and mice, the heart regrew after injury. It now sells as a research chemical with no human dosing or safety data.
What people report
Reports, not study results
The good
- Nobody in the forums describes actually taking it. Interest comes only from the animal results.
The bad
- There is no real supply. Forum threads are about group buys and paying a lab to make it.
- People guess a dose by scaling up an animal study, which is not a safe way to dose.
- Be wary of any seller claiming user results. Nobody in the forums reports taking it.
Where these come from: LongeCity threads, as summed up on this page, plus the animal studies on this page.
My bottom line
Regrowing a heart in a zebrafish is not the same as in you. A research chemical with no human data is not something I would put in my body.
An opinion, not a finding. I am a coach, not a doctor.
What it has been measured to do
What people using it report
Real people telling you what happened to them. Nobody checked it, and the people who post are not a fair sample, so it cannot prove anything works. It is still the best guide on this page to what people actually do with Trodusquemine, what they expect, and what goes wrong. The full account, including the negative reports, is below.
Animal and lab work, not yet tested in people
Real results, but from animals or cells, not people. What works in a mouse often does not work the same way in a person. Nobody can patent this, so nobody would ever earn back the cost of a study in people. That is usually why there is none.
- Losing weight1 animal or lab study · users report on this
- Losing fat specifically1 animal or lab study · users report on this
34 of the 36 indexed goals have no study of any kind behind Trodusquemine
No study in people, animals or cells on this page reports a result for these. That does not prove Trodusquemine does nothing for them. It does mean anything you have heard about Trodusquemine and one of these did not come from a study cited here.
Show full evidence
What is Trodusquemine?
Trodusquemine is a compound first found in dogfish sharks. It blocks an enzyme called PTP1B. It regrew heart tissue in zebrafish and mice, and made fat mice lose fat only. Early human trials never published any results on whether it works.
Trodusquemine blocks an enzyme called PTP1B, which acts as a brake on insulin and on leptin, the fullness hormone. It also gets into the brain. In animals, weight loss came only from fat, and the heart and other tissues regrew after injury. Early human studies in obesity and cancer happened years ago, with no published results on benefit. It now sells as a research chemical with no human dosing or safety data.
How does Trodusquemine work?
It blocks PTP1B, an enzyme that dampens insulin and leptin signals, so those signals get stronger. In injured tissue, blocking PTP1B also seems to switch on repair.
What do people who took Trodusquemine report?
This is what real people say happened to them, good and bad. Nobody measured it. A report cannot tell a real effect from the lift people get just from expecting it to work, from a diet or training change made at the same time, or from what was really in the vial. We still put it near the top. It is the next best thing to a study in people: what happens when real people use it, including what goes wrong.
- The discussion is about obtaining it rather than about taking it, which is the finding. Development was abandoned when the company behind it ceased trading, there is no supply, and threads consist of group buy attempts and proposals to pay a synthesis laboratory to make it.
- Dose is guesswork done in public. People scale a single dose animal study by body weight and arrive at single figure milligram amounts for themselves, and note that the dose range used in the human trials was not available to them in the public trial records.
- Interest is driven entirely by animal results on arterial plaque and on fat mass after a single dose, and posters are explicit that this is what they are extrapolating from.
- There are no effect reports, no timelines and no side effect accounts in this discussion, because nobody in it describes having actually taken it. Anyone reading a vendor page claiming user experience with this compound should weigh that against the absence of any in the forums where it is discussed.
Sources: LongeCity supplement and group buy threads reached through site-restricted search extracts because that board timed out on direct fetch from this environment, September 2026. Nothing above is attributed to any specific post and no post is reproduced.
The evidence, in charts
Fig. 1a · how many people
0people have taken this in any study cited here
0 people · 0 studies in people
What this page cites instead is 2 animal studies. None of them gave the compound to a person.
Counted from the list of sources on this page. We draw this chart only when a study in people is cited. An empty one is the answer, not a gap in the page.
Fig. 1b · evidence mix
None of the 2 sources here are studies in people.
- Animal study · done in animals2100%
Counted from the list of sources on this page. It counts only what we cite, so there may be more studies out there. A review counts once, however many studies it sums up.
Fig. 2 · evidence over time
Sources here come from just two years, 2010 and 2017.
Too few different years on this page to draw a timeline. The newest source on file is from 2017, more than five years ago. Research on it may have gone quiet.
Fig. 3 · legal status at a glance
US
Not approved
UK
Not approved
AU
Not approved
CA
Not approved
Not approved in any of the four countries shown. This is what the law says, not a verdict on the science. See Legal status below for the full text and any notes.
Fig. 4 · how much does what
Nobody has tested different amounts in people
This chart would show how the effect changes as the amount goes up. For this compound, nobody has measured that in people. So we leave it empty. We will not borrow an animal chart and pretend it works the same in people.
Fig. 5 · what the molecule is
- Kind of compound
- Small molecule
- Molecule weight
- 685.1 Da
- Half-life
- Stated in words, not a numbersee the exact wording below
- Chain length
- None on file
No amino acid sequence is on file for Trodusquemine, which is expected: a small molecule is not built from amino acids.
The studies we cite
- Animal study2017MSI-1436 stimulates regeneration of heart and multiple tissues
In zebrafish and mice. The heart regrew after injury, including in mice after a heart attack.
Cardiac regeneration in zebrafish and post-infarct mice.
- Animal study2010Trodusquemine causes fat-specific weight loss in diet-induced obese mice
In fat mice on a rich diet. Weight loss came only from fat.
Weight loss confined to adipose tissue.
Common questions
Has Trodusquemine been tested in people?
Not in any study cited here. Trodusquemine is a compound first found in dogfish sharks. It blocks an enzyme called PTP1B. It regrew heart tissue in zebrafish and mice, and made fat mice lose fat only. Early human trials never published any results on whether it works.
What is the Trodusquemine dosage?
No human dose established. No published study on this page has given this compound to people and reported a result. 2 animal studies, no human study
Is Trodusquemine FDA-approved?
Once tested as a drug; not approved
Does trodusquemine regenerate the human heart?
Nobody knows. The regrowth results are in fish and mice. No human study of benefit has been published.