Calcium AKG dosage and evidence
Written by Aaron CuhaReviewed Sep 2026
The short answer
Calcium AKG is a supplement made from a natural body chemical, taken for healthy ageing. One mouse study found longer life. The US government's bigger mouse program found none, at two starting ages.
Evidence grade for Calcium AKG: Preliminary. The rule: studied in people, but no published study has had people take it. The sum on this page: 1 human study where nobody was given it. A grade counts how much has been done to people, not whether it works.
- People given it
- 0
- Human studies
- 0
- Found nothing
- 0
Dose
No human dose established
No published study on this page has given this compound to people and reported a result.
1 human study where nobody was given it
3 effects reported, 2 unwanted, 1 wanted, by people using it, not a trial
Goal pages: Ageing and longevity
In plain English
In plain English, from Aaron
This is how I would explain it to a friend. The evidence, with the numbers, is further down the page.
Calcium AKG is a salt of a metabolite your cells already use to make energy. People take it as a longevity pill. It is a supplement, not a drug.
What people take it for
- A younger score on a biological age test.
- A longer life, from one mouse paper.
- A stack item next to the NAD pills.
What studies in people showed
People first. A look back at 42 people who already bought the pill reported a younger DNA age score. Nobody was put in a comparison group. People who buy longevity pills change other things at the same time. A test score is not a year of life. In mice, one 2020 paper said calcium AKG extended life. The US mouse programme, run at several sites, then tested it at two starting ages and found no lifespan effect.
What people report
Reports, not study results
The good
- Some users like the idea of a metabolite rather than a hormone.
The bad
- It is expensive for a file this thin.
- The biological age drop comes from a group of shoppers with nobody to compare them to.
Where these come from: The mouse papers and the 42 person look back are on this page. The price complaint is from longevity forums.
My bottom line
One striking mouse paper and a thin human file. I would wait.
An opinion, not a finding. I am a coach, not a doctor.
What it has been measured to do
Animal and lab work, not yet tested in people
Real results, but from animals or cells, not people. What works in a mouse often does not work the same way in a person. Nobody can patent this, so nobody would ever earn back the cost of a study in people. That is usually why there is none.
- Living longer2 animal or lab studies
35 of the 36 indexed goals have no study of any kind behind Calcium AKG
No study in people, animals or cells on this page reports a result for these. That does not prove Calcium AKG does nothing for them. It does mean anything you have heard about Calcium AKG and one of these did not come from a study cited here.
Show full evidence
What is Calcium AKG?
Calcium AKG is a supplement made from a natural body chemical, taken for healthy ageing. One mouse study found longer life. The US government's bigger mouse program found none, at two starting ages.
Alpha-ketoglutarate, or AKG, is a chemical cells use to make energy and run other jobs. Levels drop with age. The calcium form, Ca-AKG, is sold as a longevity supplement. In people, the only data is a look back at 42 users over about 7 months, with no comparison group. It reported a younger score on a DNA ageing test. In mice, a 2020 study found longer life and less frailty. But the US government's ageing test program tried AKG at two starting ages and found no longer life at either. One detail matters. In the 2022 group of mice, the food held 3,262 parts per million of AKG, against a target of 20,000. So someone could argue the dose was too low, and we say so here.
How does Calcium AKG work?
It supplies a key chemical cells use to make energy. It also feeds enzymes that control how genes are switched on and how cells age.
What have studies in people found about Calcium AKG?
The only study in people is a look back at 42 people who already bought the pill, with no comparison group. The mouse results did not hold up in the bigger mouse program.
- Rejuvant 2021: a look back at 42 users over about 7 months found a younger DNA ageing score. Nobody was compared against, and nobody got a dummy pill.
- In mice, 2020: calcium AKG in the food made mice live longer.
- In mice, the US ageing test program: AKG did not make males or females live longer at either starting age.
What this does not tell you: People who buy a longevity pill often change other things at the same time. A DNA ageing score is not a year of life. The careful mouse test found no longer life.
The evidence, in charts
Fig. 1a · how many people
1study in people cited, but none says how many people took part
number of people not stated
We do not draw a total, because none of the studies in people on this page gives one. Read the sources below for what each study measured.
We read the number of people from the source lines on this page. Where a line gives no number, we count nothing for it. We do not guess.
Fig. 1b · evidence mix
1 of 4 sources here is a study in people. The rest are not.
- Study in people · done in people125%
- Animal study · done in animals375%
Counted from the list of sources on this page. It counts only what we cite, so there may be more studies out there. A review counts once, however many studies it sums up.
Fig. 2 · evidence over time
The studies cover 4 different years, 2020 to 2026, counted from the list of sources on this page.
Fig. 3 · legal status at a glance
US
Not approved
UK
Not approved
AU
Not approved
CA
Not approved
Not approved in any of the four countries shown. This is what the law says, not a verdict on the science. See Legal status below for the full text and any notes.
Fig. 4 · how much does what
Nobody has tested different amounts in people
This chart would show how the effect changes as the amount goes up. For this compound, nobody has measured that in people. So we leave it empty. We will not borrow an animal chart and pretend it works the same in people.
Fig. 5 · what the molecule is
- Kind of compound
- Supplement
- Molecule weight
- 184.2 Da (AKG)
- Half-life
- Stated in words, not a numbersee the exact wording below
- Chain length
- None on file
No amino acid sequence is on file for Calcium AKG, which is expected: a supplement is not built from amino acids.
The studies we cite
- Study in people2021Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging in the TruAge DNA methylation test
Nobody ran a trial here. Researchers looked back at 42 people who had bought and used the supplement for roughly seven months, and compared their biological age test before and after. That design cannot show cause. People who buy longevity supplements tend to change other things at the same time, and a test result is not a year of life.
Retrospective analysis of 42 users over about 7 months reported a younger epigenetic-age score. Uncontrolled, so it cannot show cause.
- Animal study2026Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice
In mice: the US government's ageing test program gave AKG to mice starting at two different ages. Neither males nor females lived longer at either age.
NIA Interventions Testing Program: alpha-ketoglutarate did not increase lifespan in male or female mice at either starting age tested.
- Animal study2024Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin
In mice: a second group in the same program tested AKG along with five other compounds. It did not help males or females live longer.
A second Interventions Testing Program cohort testing alpha-ketoglutarate among six agents: no lifespan benefit in either sex.
- Animal study2020Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
In mice: calcium AKG in the food made mice live longer and spend less of their life frail. Their blood showed lower levels of swelling signals.
Dietary calcium AKG extended lifespan and compressed frailty in C57BL/6 mice, with lower systemic inflammatory cytokines.
Common questions
Has Calcium AKG been tested in people?
Not in a completed trial cited here. 1 human study where nobody was given it. Calcium AKG is a supplement made from a natural body chemical, taken for healthy ageing. One mouse study found longer life. The US government's bigger mouse program found none, at two starting ages.
What is the Calcium AKG dosage?
No human dose established. No published study on this page has given this compound to people and reported a result. 1 human study where nobody was given it
Is Calcium AKG FDA-approved?
Sold as a supplement; not an approved drug
Is Calcium AKG proven to reverse aging?
No. One early look at users suggested a younger DNA ageing score, and one mouse study was encouraging. The bigger mouse program found no longer life. It is early, and it is not proof of reversing ageing.
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