GlyNAC
GlyNAC (Glycine + N-Acetylcysteine)
A combination of glycine and NAC studied in older adults for restoring glutathione and improving multiple markers of aging.
Overview
GlyNAC is the combination of the amino acid glycine and N-acetylcysteine, the two building blocks the body needs to make glutathione. Trials from a Baylor research group in older adults reported that GlyNAC restored glutathione, reduced oxidative stress and inflammation, and improved several aging-related measures including strength and cognition. The studies are small, so the evidence is promising but preliminary. It is a supplement combination.
Mechanism of action
Supplies glycine and cysteine to rebuild depleted glutathione, lowering oxidative stress and supporting mitochondrial function.
Key studies & citations
- Human2021
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: results of a pilot clinical trial
24 weeks of GlyNAC in older adults corrected glutathione deficiency and improved strength, gait speed and cognition; benefits faded after stopping.
Clinical and Translational Medicine - Human2023
Supplementing glycine and N-acetylcysteine (GlyNAC) in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and aging hallmarks: a randomized clinical trial
16-week placebo-controlled RCT: GlyNAC, not placebo, improved or corrected multiple aging-related defects; small sample.
Journals of Gerontology Series A
Frequently asked questions
How is GlyNAC different from taking glutathione?
Rather than supplying glutathione, which is poorly absorbed, GlyNAC provides the raw materials so the body makes its own, which trials suggest is more effective.