Argireline
Acetyl Hexapeptide-8 (Argireline)
Also known as: Acetyl Hexapeptide-3
A topical cosmetic peptide marketed as a 'Botox-like' wrinkle reducer that relaxes expression lines at the skin surface.
Overview
Argireline is a synthetic hexapeptide widely used in anti-wrinkle skincare, often described as a topical alternative to Botox. It is proposed to reduce the intensity of muscle contractions that form expression lines by interfering with neurotransmitter release. Small studies suggest modest reductions in wrinkle depth. It is a cosmetic ingredient, not a drug.
Mechanism of action
Mimics part of the SNAP-25 protein to modestly interfere with neurotransmitter release at the surface, softening expression lines.
Key studies & citations
- Human2002
A synthetic hexapeptide (Argireline) with antiwrinkle activity
Original report: Ac-EEMQRR-NH2 mimics SNAP-25 to interfere with SNARE assembly; topical use reduced wrinkle depth in a small study.
International Journal of Cosmetic Science - Human2013
The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
60 subjects, 4 weeks: 48.9% subjective anti-wrinkle response versus 0% with placebo; roughness parameters decreased.
American Journal of Clinical Dermatology
Frequently asked questions
Is Argireline as strong as Botox?
No. It is a topical cosmetic peptide with modest surface effects, not an injected neurotoxin. Any wrinkle reduction is much smaller than Botox.