Matrixyl
Palmitoyl Pentapeptide-4 (Matrixyl)
Also known as: Pal-KTTKS
A widely used topical skincare peptide that signals the skin to produce more collagen, studied for fine lines and firmness.
Overview
Matrixyl is a lipid-attached pentapeptide used extensively in anti-aging skincare. It acts as a signal peptide, prompting skin cells to produce more collagen and extracellular matrix, which can improve fine lines and firmness. It is one of the better-studied cosmetic peptides, with several controlled topical studies. It is a cosmetic ingredient, not a drug.
Mechanism of action
Signals dermal fibroblasts to increase collagen and matrix production, supporting skin structure.
Key studies & citations
- In vitro1993
A pentapeptide from type I procollagen promotes extracellular matrix production
The KTTKS pentapeptide stimulated collagen and fibronectin production in fibroblasts, the basis for palmitoyl pentapeptide.
Journal of Biological Chemistry - Human2005
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
93 women, 12-week split-face trial: pal-KTTKS significantly reduced wrinkles and fine lines versus placebo moisturizer.
International Journal of Cosmetic Science
Frequently asked questions
How is Matrixyl different from Argireline?
Matrixyl signals collagen production to improve skin structure, while Argireline aims to relax expression lines. They are often combined in skincare.