HGH Fragment 176-191
Growth Hormone Fragment 176-191
The lipolytic C-terminal fragment of growth hormone studied in animals for fat loss without growth-hormone-like effects on glucose or IGF-1.
Overview
HGH Fragment 176-191 is the region of growth hormone associated with its fat-metabolizing activity. In animal studies it promotes fat breakdown without the insulin resistance or tissue-growth effects of full growth hormone. Human clinical evidence is limited, and it is closely related to AOD-9604, which was engineered from this fragment. It is not an approved drug. Note: the product sold as 'HGH Fragment 176-191' is chemically the same modified fragment as AOD-9604 (Tyr-hGH177-191); the AOD-9604 profile carries the regulated-trial history.
Mechanism of action
Mimics the lipolytic C-terminal activity of growth hormone on fat cells while lacking its growth-promoting and glucose effects.
Key studies & citations
- Animal2000
Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats
The C-terminal 177-191 domain of hGH mimicked GH's lipolytic actions on adipose tissue and reduced weight gain in obese rats without insulin resistance.
Journal of Molecular Endocrinology - Animal2000
Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism
30 days of oral hGH fragment (AOD-9401) lowered weight gain in ob/ob mice without changing food intake and increased lipolysis in obese rodent and human adipose tissue ex vivo.
American Journal of Physiology: Endocrinology and Metabolism - Animal2001
The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice
The stabilized fragment analogue AOD9604 reduced body weight and fat in obese mice; the closest human data come from the AOD9604 programme, not the native fragment.
Endocrinology
Frequently asked questions
Is HGH Fragment 176-191 the same as AOD-9604?
They are closely related. AOD-9604 is a modified version of this fragment with an added stabilizing residue. Both are studied for fat metabolism and neither is approved.