B7-33
B7-33, single-chain relaxin analog
A simplified relaxin analog that activates the RXFP1 receptor with a bias toward anti-fibrotic signaling; animal and cell data only.
Overview
Relaxin is a hormone with anti-fibrotic effects but is hard to manufacture. B7-33 is a single-chain derivative that reproduced relaxin's anti-fibrotic actions in animal models of heart and lung fibrosis without the receptor-desensitizing cAMP signaling. There are no human trials.
Mechanism of action
Functionally selective RXFP1 agonism biased toward pERK-mediated anti-fibrotic signaling.
Key studies & citations
- Animal2016
A single-chain derivative of the relaxin hormone is a functionally selective agonist of RXFP1
Anti-fibrotic effects in animal models.
Chemical Science - Animal2019
B7-33 coated implants reduce fibrosis
Reduced fibrotic capsule formation.
ACS Applied Materials and Interfaces
Frequently asked questions
Can B7-33 soften scars?
Untested in people. Its evidence is animal fibrosis models.