Enobosarm dosage and evidence
Written by Aaron CuhaReviewed Sep 2026
The short answer
The drug sold on the grey market as ostarine. In proper studies, 3 mg added to semaglutide cut muscle loss by 71 percent in adults over 60.
Evidence grade for Enobosarm: Moderate. The rule: at least one finished study in people, and at least 100 people who took it. The sum on this page: 1 completed trial, 159 people given it. A grade counts how much has been done to people, not whether it works.
- People given it
- 159
- Human studies
- 1
- Found nothing
- 1
Dose
No human dose established
Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose.
1 completed trial, 159 people given it
5 effects reported, by people using it, not a trial
Goal pages: Fat loss and metabolism, Muscle and strength, Ageing and longevity, Immune system and inflammation
In plain English
In plain English, from Aaron
This is how I would explain it to a friend. The evidence, with the numbers, is further down the page.
Enobosarm is the drug sold on the grey market as ostarine. It switches on the male hormone receptor, mostly in muscle and bone. In proper studies it is being tested to save muscle during weight loss. It is not approved, and selling it as a supplement is illegal.
What people take it for
- Keeping muscle on semaglutide.
- Building muscle, as a grey market SARM.
What studies in people showed
In a study of adults aged 60 and older on semaglutide, adding 3 mg cut muscle loss from 4.1 percent to 1.2 percent over 16 weeks. 54.5 percent fewer people had a big drop in stair-climb power. Stomach side effects were fewer too. These were company figures. In an older study, 159 people losing weight to cancer gained about 1 to 1.5 kg of muscle over up to four months. The larger cancer studies that followed failed.
What people report
Reports, not study results
The good
- In the studies on this page, older adults on semaglutide kept most of the muscle they would have lost.
The bad
- Grey market SARM products have been linked to liver injury and to shutting down the body's own hormones.
- Grey market products are often mislabelled.
Where these come from: The study results are from the studies on this page. The grey market warnings are from the safety answer on this page. We have not collected forum reports for this one yet.
My bottom line
The real drug at 3 mg, with check-ups, is one thing. Grey market ostarine is another. Do not take a hormone drug from a website. Lift, and get your blood work done.
An opinion, not a finding. I am a coach, not a doctor.
What it has been measured to do
Measured in people
Goals Enobosarm has been tested for in people, biggest studies first. We count only what the studies on this page say, so the real numbers may be higher.
- Losing weight159 people · 1 study · 1 found nothing
- Keeping or building muscle159 people · 1 study · 1 found nothing
- Cancer and tumours159 people · 1 study · 1 found nothing
What people using it report
Real people telling you what happened to them. Nobody checked it, and the people who post are not a fair sample, so it cannot prove anything works. It is still the best guide on this page to what people actually do with Enobosarm, what they expect, and what goes wrong. The full account, including the negative reports, is below.
29 of the 36 indexed goals have no study of any kind behind Enobosarm
No study in people, animals or cells on this page reports a result for these. That does not prove Enobosarm does nothing for them. It does mean anything you have heard about Enobosarm and one of these did not come from a study cited here.
Show full evidence
What is Enobosarm?
The drug sold on the grey market as ostarine. In proper studies, 3 mg added to semaglutide cut muscle loss by 71 percent in adults over 60.
Enobosarm switches on the androgen (male hormone) receptor, mainly in muscle and bone. It failed earlier programs in cancer-related muscle wasting. It is also widely misused, under the name ostarine, as an unapproved muscle drug called a SARM. Veru's QUALITY study gave it with semaglutide to adults aged 60 and older. Over 16 weeks, lean-mass loss fell from 4.1 percent to 1.2 percent. 54.5 percent fewer people had a big drop, of 10 percent or more, in stair-climb power, and there were fewer stomach side effects. In an earlier study, 159 people with cancer who were losing weight gained roughly 1 to 1.5 kg of muscle over up to about four months. A 3 mg dose was picked for final-stage studies, and a study on keeping weight off is signing people up.
How does Enobosarm work?
It switches on the androgen receptor mostly in muscle and bone. That helps build muscle protein, with less effect on the prostate and skin than testosterone.
What do people who took Enobosarm report?
This is what real people say happened to them, good and bad. Nobody measured it. A report cannot tell a real effect from the lift people get just from expecting it to work, from a diet or training change made at the same time, or from what was really in the vial. We still put it near the top. It is the next best thing to a study in people: what happens when real people use it, including what goes wrong.
- Almost never discussed under this name. The community talks about it by its research code, in bodybuilding and testosterone replacement contexts rather than clinical ones, which means the clinical framing and the forum framing barely overlap.
- Reports of nothing happening are prominent and come from experienced lifters who describe following an amount and a schedule exactly. One detailed account describes roughly three weeks at several times the amount usually suggested with no change in strength, endurance or body composition, and no side effects either.
- Shutting down the body's own testosterone making is the negative raised most consistently, and posters point out that it shows up at low single-digit daily amounts, which undercuts the common claim that small amounts are free of it. Incomplete recovery afterwards is the specific worry described.
- The framing that recurs from more experienced posters is a very small daily amount described as muscle sparing while in a deficit, with the argument that the several times larger amounts people actually take build a little muscle at best and not worth what they cost in recovery.
- Adverse effects raised include lowered HDL, raised liver enzymes and fatigue, and the standing position in these threads is that what vendors of these compounds publish about them is not accurate.
Sources: SARM threads on ExcelMale, including a personal trial thread and a safety and effectiveness thread, found by site-restricted search and read directly, with MESO-Rx threads surfaced by the same search, September 2026. Nothing above is attributed to any specific post and no post is reproduced.
The evidence, in charts
Fig. 1a · how many people
159people, across 1 study in people cited here
| Study | People | Share |
|---|---|---|
| The Lancet Oncology 2013 | 159 | 100% |
The whole total is one study of 159. Counts are the number of people each study on this page says it signed up. That includes studies that only watched people and gave nobody the compound. 2 more studies in people give no headcount and are not counted here. Studies still signing people up are left out, and only studies cited on this page are counted.
Fig. 1b · evidence mix
All 3 sources here are studies in people.
- Study in people · done in people3100%
Counted from the list of sources on this page. It counts only what we cite, so there may be more studies out there. A review counts once, however many studies it sums up.
Fig. 2 · evidence over time
The studies cover 3 different years, 2013 to 2026, counted from the list of sources on this page.
Fig. 3 · legal status at a glance
US
Not approved
UK
Not approved
AU
Not approved
CA
Not approved
Not approved in any of the four countries shown. This is what the law says, not a verdict on the science. See Legal status below for the full text and any notes.
Fig. 4 · how much does what
Nobody has tested different amounts in people
This chart would show how the effect changes as the amount goes up. For this compound, nobody has measured that in people. So we leave it empty. We will not borrow an animal chart and pretend it works the same in people.
Fig. 5 · what the molecule is
- Kind of compound
- Small molecule
- Molecule weight
- 389.3 Da
- Half-life
- About 24 hoursLong, 1 to 7 days
- Chain length
- None on file
No amino acid sequence is on file for Enobosarm, which is expected: a small molecule is not built from amino acids.
The studies we cite
- Study in people2025Veru reports positive safety and efficacy results from Phase 2b QUALITY study
In older adults, adding enobosarm protected most of the muscle they would otherwise have lost. Over 16 weeks, muscle loss on semaglutide fell from about 4% of body mass to about 1%. Far fewer people had a big drop in stair-climbing power, and gut side effects were fewer too. These are company-reported mid-stage figures in a group picked because they had the most to lose. The same drug failed earlier trials in cancer-related muscle wasting.
71% less lean-mass loss with semaglutide in adults 60 and older.
- Study in people2026Veru enrolls first patient in Phase 2b PLATEAU maintenance study
This trial is enrolling and has published nothing. It asks a different question from the last one: whether enobosarm can hold weight and muscle steady after someone stops a GLP-1 drug. Most people regain weight after stopping, so the question is worth asking. No answer has been reported.
Tests enobosarm after GLP-1 discontinuation.
- Study in people2013Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial
Muscle did grow, in people who were losing it to cancer. 159 patients who had already lost weight took one of two doses of enobosarm or a dummy pill for up to about four months. Muscle mass rose on both doses, by roughly 1 to 1.5 kg, while the dummy group did not change. Here is the limit. Growing muscle is not the same as being able to do more, and the larger studies that followed did not succeed.
159 patients with cancer and at least 2% weight loss, randomised to enobosarm 1 mg, 3 mg or placebo for up to 113 days. Total lean body mass rose significantly on both doses (median 1.5 kg on 1 mg, 1.0 kg on 3 mg) while placebo did not change. This is the Phase 2 trial that preceded the POWER Phase 3 program.
Where to buy Enobosarm
2 sellers list Enobosarm in our latest read. They are ranked by trust score, then by archive rating, then by certificate tier, then by the lowest price per milligram. Archive evidence is counted before source-backed. Each path is out of 4, and the two are not added. A higher price does not raise the score. The letter is the certificate chip. 0 of them have a published certificate that names Enobosarm.
Some seller links may pay this site when you buy through them. A payment never changes a seller's tier or rank, and no seller has a say in any page.
| Seller | Trust score | Vial sizes | From, per mg | Certificate for Enobosarm | Seller link |
|---|---|---|---|---|---|
| SSP Research | 49 WeakSource-backed 2 of 4. Archive evidence 1 of 4.B | 25 mg | $3.00 | None found for Enobosarm | View |
| Modern Aminos | 28 InsufficientSource-backed 1 of 4. Archive evidence 0 of 4.C | 15 mg | $4.93 | None found for Enobosarm | View |
- LC Lab-confirmed: the issuing laboratory echoed this certificate back
- A Current certificate, independent laboratory named, laboratory not yet checked
- B Certificate published, but no laboratory link, older than a year, or the laboratory did not recognise the published lookup
- C No certificate could be read
Every listing and vial size for Enobosarm · How the trust score is counted
Sellers named on the price pages are ranked by certificate tier, then price, and any affiliate income is disclosed there. Naming a seller is not a recommendation to buy or use anything.
Common questions
Has Enobosarm been tested in people?
Yes. 159 people given it across 1 completed trial cited here, 1 of which found nothing. The drug sold on the grey market as ostarine. In proper studies, 3 mg added to semaglutide cut muscle loss by 71 percent in adults over 60.
What is the Enobosarm dosage?
No human dose established. Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose. 1 completed trial, 159 people given it
Is Enobosarm FDA-approved?
Investigational; not approved for any use. SARMs are lab-made drugs that act like testosterone. Unapproved SARM products are illegal to sell as supplements.
Is ostarine the same as enobosarm?
Yes. Ostarine is the common name for the same molecule sold illegally. The study drug is made to drug standards and given at set doses.
Is it safe?
Grey market SARM products have been linked to liver injury and to shutting down the body's own hormones, and they are often mislabelled. The studies use 3 mg with check-ups. That says nothing about unregulated products.