PT-141 with oxytocin dosage and evidence
Written by Aaron CuhaReviewed Sep 2026
The short answer
PT-141 with oxytocin is a 15 mg vial, usually 10 mg bremelanotide with 5 mg oxytocin.
Evidence grade for PT-141 with oxytocin: Limited. The rule: people have taken it in a published study, but fewer than 100 of them. The sum on this page: 3 completed trials, 10 people given it. A grade counts how much has been done to people, not whether it works.
- People given it
- 10
- Human studies
- 3
- Found nothing
- 0
Dose
No human dose established
Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose.
3 completed trials, 10 people given it
6 effects reported, 4 unwanted, 2 wanted, by people using it, not a trial
Goal pages: Brain, memory and mood, Hormones and growth hormone, Sleep
In plain English
In plain English, from Aaron
This is how I would explain it to a friend. The evidence, with the numbers, is further down the page.
A 15 mg vial, usually 10 mg PT-141 and 5 mg oxytocin. PT-141 is an approved drug with two big trials behind it. The oxytocin half was tested for this exact job and it lost to a dummy spray.
What people take it for
- More desire and arousal.
- Feeling closer to a partner.
- Help with sex problems that talking has not fixed.
What studies in people showed
The mix has never been tested. PT-141 has two big final stage trials in women with low sex drive, which is what it is approved for. Now the oxytocin. Thirty women with sexual problems used a nasal spray of oxytocin or a dummy spray before sex for eight weeks, then swapped. Sexual function scores went up 26 percent on oxytocin and 31 percent on the dummy. Quality of life scores went up 144 percent on oxytocin and 125 percent on the dummy. Distress went down 36 percent on oxytocin and 45 percent on the dummy. There was no real difference between them. Everybody got better. The drug did not beat the dummy on anything. One more thing. That study used a nose spray on purpose. Oxytocin shot into your blood barely reaches your brain. This vial is a shot. The math: mix 15 mg with 3 mL and every unit mark carries about 33 micrograms of PT-141 and 17 of oxytocin. The approved PT-141 dose of 1.75 mg is about 53 units, which also puts in about 0.88 mg of oxytocin.
What people report
Reports, not study results
The good
- More desire and arousal within a few hours.
- A warm, close feeling that people credit to the oxytocin.
The bad
- Nausea and flushing. This is the most common report and it is a known effect of this drug family.
- Headache.
- Sore shot sites.
- People who have used PT-141 on its own often say they cannot tell the difference, which is what the oxytocin trial would predict.
Where these come from: The nausea and flushing come from proper trials of this drug family. The rest comes from forums and clinic write-ups, in an area where the dummy group of a real trial improved as much as the drug group.
My bottom line
The PT-141 half is the real thing. The oxytocin half failed its own trial and is being given by the route least likely to work. You are paying for a third of a vial that does nothing.
An opinion, not a finding. I am a coach, not a doctor.
What it has been measured to do
Measured in people
Goals PT-141 with oxytocin has been tested for in people, biggest studies first. We count only what the studies on this page say, so the real numbers may be higher.
- Mood and anxietyno headcount stated · 1 study
- Libido and sexual functionno headcount stated · 1 study
What people using it report
Real people telling you what happened to them. Nobody checked it, and the people who post are not a fair sample, so it cannot prove anything works. It is still the best guide on this page to what people actually do with PT-141 with oxytocin, what they expect, and what goes wrong. The full account, including the negative reports, is below.
33 of the 36 indexed goals have no study of any kind behind PT-141 with oxytocin
No study in people, animals or cells on this page reports a result for these. That does not prove PT-141 with oxytocin does nothing for them. It does mean anything you have heard about PT-141 with oxytocin and one of these did not come from a study cited here.
Show full evidence
What is PT-141 with oxytocin?
PT-141 with oxytocin is a 15 mg vial, usually 10 mg bremelanotide with 5 mg oxytocin. So two thirds of the powder is bremelanotide and one third is the hormone oxytocin. Bremelanotide has two large studies behind its approval. Oxytocin was tested for sex problems in 30 women, and the women on a dummy spray did just as well. The mix has never been tested.
This vial is sold as a two-part answer to sex problems. One part is for desire and arousal. One part is for feeling close. The second part is where this page has to be blunt.
Bremelanotide is an approved medicine. Two large final-stage studies tested it in women before menopause who had low sexual desire that upset them. That is a real record with real results.
Oxytocin's record for sex is not. In one study, 30 women with sex problems, before and after menopause, used 32 units of oxytocin nasal spray or a dummy spray before sex. They did this for eight weeks, then switched. Nobody knew which spray was which. Sexual function scores rose 26% on oxytocin and 31% on the dummy. Sex life quality scores rose 144% on oxytocin and 125% on the dummy. Distress about sex fell 36% on oxytocin and 45% on the dummy. The drug made no real difference. Both groups got better, and the drug did not beat the dummy on anything.
That is the most important result on this page, and it is easy to misread the way people want to. Oxytocin did not do nothing. Scores went up a lot in the women taking it. But they went up just as much in the women spraying salt water. In an area this driven by what people expect, a story about an oxytocin blend working looks exactly like the dummy group in that study.
The math on the common 10 plus 5 mg vial, mixed with 3 mL of water. There is 15 mg of powder: 66.7% bremelanotide and 33.3% oxytocin. Each mL holds 5 mg in all, 3.33 mg of bremelanotide and 1.67 mg of oxytocin. One mark on a 100 unit insulin syringe holds about 33 micrograms of bremelanotide and 17 micrograms of oxytocin. The approved bremelanotide dose is 1.75 mg. From this vial that is about 53 units, which also gives you about 0.88 mg of oxytocin. Nobody has set an oxytocin shot dose for this use. So that number just falls out of the seller's mix. Nobody chose it on purpose.
How does PT-141 with oxytocin work?
Bremelanotide presses melanocortin switches, mostly the MC4 switch in the brain. That is the desire and arousal path. Oxytocin is a small hormone, nine building blocks long, made at the base of the brain. Its jobs in labour and breastfeeding are well known. Its role in social and sexual behaviour is much less settled. Oxytocin injected into the body gets into the brain poorly. That is why most of the research uses a nasal spray.
What have studies in people found about PT-141 with oxytocin?
One half is an approved drug with two large studies. The other half was tested for this use, and people on the dummy did just as well. The mix has no study.
- Bremelanotide: two large final-stage studies in women before menopause with low sexual desire that upset them.
- Oxytocin for sex problems: 30 women, each trying oxytocin and a dummy spray. The drug made no real difference. Scores rose 26% on oxytocin and 31% on the dummy.
- Side effects of this drug family, including nausea, show up in the controlled studies.
- The blend: no published study and no listed trial.
What this does not tell you: The oxytocin study used a nasal spray. That is how oxytocin brain research is done, because injected oxytocin gets into the brain poorly. This vial is injected. That makes the oxytocin half less likely to do what it is sold for here, not more.
What do people who took PT-141 with oxytocin report?
This is what real people say happened to them, good and bad. Nobody measured it. A report cannot tell a real effect from the lift people get just from expecting it to work, from a diet or training change made at the same time, or from what was really in the vial. We still put it near the top. It is the next best thing to a study in people: what happens when real people use it, including what goes wrong.
- Nausea and flushing. This is the main report and a known side effect of this drug family.
- More desire and arousal within a few hours.
- A feeling of warmth or closeness that people credit to the oxytocin.
- Headache.
- Irritation where the shot goes in.
- No difference from bremelanotide alone, from people who have used both. That is what the oxytocin study would predict.
Sources: The nausea and flushing appear in the melanocortin controlled trials. The rest comes from forums including r/peptides and clinic write-ups, uncontrolled, in an area where people on a dummy treatment in one study improved as much as people on the drug.
The state of the research
Two things about this area make user stories almost useless, and the oxytocin study shows both. Sex scores move a long way on what people expect. They also move a long way just from being measured and talked about. The dummy group in that study raised its sex life quality score by 125%.
How the drug gets in needs its own note. Almost all the research in people that suggests oxytocin affects social and emotional behaviour uses a nasal spray. That is because oxytocin injected into the blood reaches the brain poorly. A shot under the skin takes the ingredient whose claimed effect is in the brain, and gives it by the way least likely to get it there.
The last point is about the mix. Bremelanotide has an approved dose. Oxytocin, for this use, does not. So the amount you get is whatever falls out of the seller's split when you draw the amount you actually wanted.
The evidence, in charts
Fig. 1a · how many people
10people, across 1 study in people cited here
| Study | People | Share |
|---|---|---|
| Journal of Urology 1998 | 10 | 100% |
The whole total is one study of 10. Counts are the number of people each study on this page says it signed up. That includes studies that only watched people and gave nobody the compound. 2 more studies in people give no headcount and are not counted here. Studies still signing people up are left out, and only studies cited on this page are counted.
Fig. 1b · evidence mix
All 3 sources here are studies in people.
- Study in people · done in people3100%
Counted from the list of sources on this page. It counts only what we cite, so there may be more studies out there. A review counts once, however many studies it sums up.
Fig. 2 · evidence over time
The studies cover 3 different years, 1998 to 2019, counted from the list of sources on this page. The newest source on file is from 2019, more than five years ago. Research on it may have gone quiet.
Fig. 3 · legal status at a glance
US
Not approved
UK
Not approved
AU
Not approved
CA
Not approved
Not approved in any of the four countries shown. This is what the law says, not a verdict on the science. See Legal status below for the full text and any notes.
Fig. 4 · how much does what
Nobody has tested different amounts in people
This chart would show how the effect changes as the amount goes up. For this compound, nobody has measured that in people. So we leave it empty. We will not borrow an animal chart and pretend it works the same in people.
Fig. 5 · what the molecule is
- Kind of compound
- Blend
- Molecule weight
- Not on file
- Half-life
- Stated in words, not a numbersee the exact wording below
- Chain length
- None on file
Half-life as stated on file: Not defined for the blend. Oxytocin disappears from plasma very quickly, the melanocortin component is used episodically, and the mixture has never been measured.
No amino acid sequence is on file for PT-141 with oxytocin, which is expected: a blend is not built from amino acids.
Fig. 6 · what is in the vial
66.7%of a 15 mg PT-141 with oxytocin vial is Bremelanotide (PT-141)
- Bremelanotide (PT-141)10 mg66.7%
- Oxytocin acetate5 mg33.3%
What the label says is in a standard vial. It is not a dose, and not a lab test. The seller fixes the mix, so when you draw the amount you want of one ingredient, you get a set amount of every other one with it. No study has tested this mix in people or animals.
The studies we cite
- Study in people2019Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials
Bremelanotide is the half of this vial with real evidence behind it. Its approval rests on two large studies in women before menopause who had lost sexual desire. One detail decides what those studies can be used for here. Bremelanotide was given on its own in both. No oxytocin was given with it. So nothing in this record tells you what the mix does.
Two randomised phase 3 trials of bremelanotide in premenopausal women with hypoactive sexual desire disorder, the studies on which its approval rests. Bremelanotide alone, with no oxytocin co-administered.
- Study in people2015Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial
Oxytocin was tested properly for sex problems in women, and it did not beat a dummy spray. Thirty women used an oxytocin nasal spray or a dummy spray before sex. Each tried both over 22 weeks, and nobody knew which was which. Sexual function scores rose 26% on oxytocin and 31% on the dummy. Distress about sex fell 36% and 45%. Both groups got better, and the dummy matched or beat the drug every time. Thirty women is small, but nothing here points the drug's way.
Thirty pre- and postmenopausal women with sexual dysfunction, randomised double-blind placebo-controlled crossover over 22 weeks, 32 IU of intranasal oxytocin or placebo before intercourse. Female Sexual Function Index rose 26% on oxytocin and 31% on placebo, Sexual Quality of Life 144% and 125%, and sexual distress fell 36% and 45%. There was no statistically significant treatment, sequence or interaction effect. Both improved; the drug did not beat placebo.
- Study in people1998Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study
This drug family does cause erections, shown in a very small study. Ten men each took the peptide and a dummy shot on separate days. Nobody knew which came when, and a monitor recorded firmness. Eight of the ten got a clear erection on the drug. Firmness stayed above four fifths of full for 38 minutes on average, against 3 minutes on the dummy. Nausea, yawning and stretching came with it. Those family side effects apply to bremelanotide too.
Ten men, double-blind placebo-controlled crossover with RigiScan monitoring. 8 of 10 developed clinically apparent erections on the melanocortin analogue, with mean tip rigidity above 80% lasting 38.0 minutes against 3.0 minutes on placebo. Nausea, yawning and stretching were more frequent on drug. The melanocortin class effect that also applies to bremelanotide.
Where to buy PT-141 with oxytocin
2 sellers list PT-141 with oxytocin in our latest read. They are ranked by trust score, then by archive rating, then by certificate tier, then by the lowest price per milligram. Archive evidence is counted before source-backed. Each path is out of 4, and the two are not added. A higher price does not raise the score. The letter is the certificate chip. 0 of them have a published certificate that names PT-141 with oxytocin.
Some seller links may pay this site when you buy through them. A payment never changes a seller's tier or rank, and no seller has a say in any page.
| Seller | Trust score | Vial sizes | From, per mg | Certificate for PT-141 with oxytocin | Seller link |
|---|---|---|---|---|---|
| Sigma Compounds | 49 WeakSource-backed 3 of 4. Archive evidence 1 of 4.B | 5 mg | $23.8 | None found for PT-141 with oxytocin | View |
| Pure Health Peptides | 25 InsufficientSource-backed 1 of 4. Archive evidence 0 of 4.C | 2.5 mg | $31.6 | None found for PT-141 with oxytocin | View |
- LC Lab-confirmed: the issuing laboratory echoed this certificate back
- A Current certificate, independent laboratory named, laboratory not yet checked
- B Certificate published, but no laboratory link, older than a year, or the laboratory did not recognise the published lookup
- C No certificate could be read
Every listing and vial size for PT-141 with oxytocin · How the trust score is counted
Sellers named on the price pages are ranked by certificate tier, then price, and any affiliate income is disclosed there. Naming a seller is not a recommendation to buy or use anything.
Common questions
Has PT-141 with oxytocin been tested in people?
Yes. 10 people given it across 3 completed trials cited here, 0 of which found nothing. PT-141 with oxytocin is a 15 mg vial, usually 10 mg bremelanotide with 5 mg oxytocin.
What is the PT-141 with oxytocin dosage?
No human dose established. Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose. 3 completed trials, 10 people given it
Is PT-141 with oxytocin FDA-approved?
Bremelanotide is FDA approved for low sex drive that causes distress (hypoactive sexual desire disorder) in women before menopause. Oxytocin is approved for use in labour and childbirth. The combination is not approved, and there is no approved oxytocin product for sexual function.
Does the oxytocin half work?
In the proper study that tested it for sex problems, no. Thirty women each used oxytocin nasal spray and a dummy spray, and the drug made no real difference. Scores rose 26% on oxytocin and 31% on the dummy.
What do I get per unit?
Take a 10 mg bremelanotide plus 5 mg oxytocin vial mixed with 3 mL of water. One unit holds about 33 micrograms of bremelanotide and 17 micrograms of oxytocin. The approved bremelanotide dose of 1.75 mg is about 53 units. That also gives you about 0.88 mg of oxytocin.
Is injected oxytocin the same as the nasal spray in the studies?
No, and the difference matters. The research that suggests oxytocin affects social and emotional behaviour uses a nasal spray. That is because oxytocin injected into the blood reaches the brain poorly.
Is bremelanotide approved?
Yes, for low sexual desire that causes distress, in women before menopause. That approval rests on two large final-stage studies. This blend is not the approved product.
Why does it make me nauseous?
Nausea comes with this whole drug family. It shows up in the controlled studies, including the melanotan II study where each man had both the drug and a dummy.