Is OSK Partial Reprogramming legal in the United States?

Three of the four Yamanaka genes, switched on briefly to reset the ageing marks on DNA without wiping out what kind of cell it is. One early safety trial in people is signing up 18 people, with a shot into one eye. Every result showing a benefit is in mice.

Partial reprogramming is an idea about ageing cells. It says they keep a readable record of their younger state, written as chemical tags on their DNA.

How it works: This is shown in mice. Switching on OSK partly wipes and rewrites the chemical tags on a cell's DNA, called methylation.

Approval history: Not approved in any country for any use. No reprogramming therapy has ever been approved. One investigational product, Life Biosciences ER-100, is in an early safety study that is signing up patients (NCT07290244).

Approves prescription drugs, each for a named use. It also acts against unapproved products, including peptides sold online. Compounding pharmacies, which mix drugs to order, may make some compounds with a prescription. That only applies when the FDA puts the compound in a category of bulk ingredients it allows.

The legal category above is how The Longevity Archive reads U.S. Food and Drug Administration listings for OSK Partial Reprogramming on the reviewed date. It is not a legal opinion. Rules change. Bringing a compound into the country, prescribing it and owning it can each be treated differently. Check with the agency before you act on anything here.

Check FDA directly

Whether OSK Partial Reprogramming is banned in sport is set by the World Anti-Doping Code and by military rules, not by its legal status in the United States. Before you compete or get tested, look up OSK Partial Reprogramming by name on the Prohibited List, or look up a named product in Global DRO. Under the World Anti-Doping Code, category S0 bans, at all times, any drug-like substance that meets two tests. No other section of the List covers it. And no government health regulator anywhere has a current approval for it as a treatment in people. Many substances that are approved somewhere are banned by name in another section. So approval does not mean a substance is allowed in sport.

• WADA Prohibited List
• Global DRO (check a named product)
• USADA (US athletes)
• Operation Supplement Safety (US service members)

The rules you compete or serve under decide this, not this page.