Legal status · United States
Is Modified GRF 1-29 legal in the United States?
Written by Aaron CuhaReviewed Sep 2026
Direct answer
No. Modified GRF 1-29 is not an approved medicine in the United States; its classification is "Not approved; research use only". Nothing containing it is authorized for any use in people. Vials labeled "for research use only" are not exempt: that label does not make human use lawful. On the evidence, 2 human studies are cited on its profile.
Modified GRF 1-29 in the United States at a glance
| Classification | Not approved; research use only |
|---|---|
| Note | Research chemical only. Prohibited in sport by the World Anti-Doping Agency as a growth hormone secretagogue, and identified in seized doping material. |
| FDA approval status | Not approved for any indication and not evaluated. Sermorelin, the unmodified GRF 1-29, was an approved medicine in the United States and is no longer marketed in its original form. Tesamorelin, a different GHRH analogue, is approved for HIV-associated lipodystrophy. |
| Human studies cited | 2 of 5 citations on the profile |
| Reviewed | Sep 2026 |
Classification and note come from the Modified GRF 1-29 profile, checked against U.S. Food and Drug Administration (FDA) listings at the reviewed date.
What this means
- 01
No product containing Modified GRF 1-29 is approved by FDA for any use in the United States, so nothing on the market is authorized for people.
- 02
"Research use only" is a vendor label, not a legal category that permits human use. It does not exempt a product from medicines law.
- 03
Importing, supplying or promoting it for human use can fall under medicines legislation in the United States. This page is general information, not legal advice.
What Modified GRF 1-29 is
Sold as CJC-1295 without DAC, which is a contradiction: the DAC is what makes a molecule CJC-1295. The human trial everyone quotes, 2 to 10 fold higher growth hormone for 6 days or more with a half-life of 5.8 to 8.1 days, was run on the DAC form. No human trial of the version without the DAC has been located.
Start with the naming, because the naming is the error. The 2005 paper that created CJC-1295 tested three maleimido derivatives of human growth hormone releasing factor 1-29 designed to bond to the free thiol on cysteine 34 of serum albumin.
Mechanism: A growth hormone releasing hormone analogue acting at the GHRH receptor on anterior pituitary somatotrophs to trigger growth hormone release, which raises IGF-1 downstream. The tetrasubstitution of the native GRF 1-29 sequence resists dipeptidyl peptidase IV cleavage, extending the peptide's survival in plasma from minutes to somewhat longer, but it does not confer albumin binding.
Regulatory history: Not approved for any indication and not evaluated. Sermorelin, the unmodified GRF 1-29, was an approved medicine in the United States and is no longer marketed in its original form. Tesamorelin, a different GHRH analogue, is approved for HIV-associated lipodystrophy.
How FDA treats this kind of product
Approves prescription drugs by indication and polices unapproved products, including peptides sold online. Compounding pharmacies may prepare some compounds under a prescription when the FDA places them on a permitted bulk-substances category.
The classification above is the The Longevity Archive reading of U.S. Food and Drug Administration listings for Modified GRF 1-29 at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.
Modified GRF 1-29 in other countries
Frequently asked questions
Is Modified GRF 1-29 legal in the United States?
No. Modified GRF 1-29 is not an approved medicine in the United States; its classification is "Not approved; research use only". Nothing containing it is authorized for any use in people. Vials labeled "for research use only" are not exempt: that label does not make human use lawful. On the evidence, 2 human studies are cited on its profile. Note: Research chemical only. Prohibited in sport by the World Anti-Doping Agency as a growth hormone secretagogue, and identified in seized doping material.
Can I buy Modified GRF 1-29 in the United States?
No approved product exists to buy. In the United States Modified GRF 1-29 is classified as "Not approved; research use only", so there is no licensed pharmacy product. Vendors selling it "for research use only" are not selling it for human use, and that label does not change its legal status. This site does not list or recommend vendors. Note: Research chemical only. Prohibited in sport by the World Anti-Doping Agency as a growth hormone secretagogue, and identified in seized doping material.
Is Modified GRF 1-29 FDA approved?
No. FDA status: Not approved for any indication and not evaluated. Sermorelin, the unmodified GRF 1-29, was an approved medicine in the United States and is no longer marketed in its original form. Tesamorelin, a different GHRH analogue, is approved for HIV-associated lipodystrophy.. Current US classification: "Not approved; research use only". On the evidence, 2 human studies are cited on its profile.
Related compounds in the United States
Full research profile
Mechanism, cited studies, FDA status and the full legal summary for Modified GRF 1-29 live on its compound profile.
Modified GRF 1-29 profileThis page is general information about the regulatory status of Modified GRF 1-29 in the United States, current as of Sep 2026. It is not legal advice, and classifications change; check U.S. Food and Drug Administration directly or consult a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships and does not recommend where to buy anything.