Peptide finder

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Pick as many as you like. The number on each one is how many people it has been measured in across the whole archive. So you can see where the evidence is before you choose.

1. 01MethotrexateSmall moleculeStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 5,022 people given it.4 reported

   5,022 people2 studies1 found nothing

   • found nothingLow-dose methotrexate did not prevent heart attacks or strokes in people who already had heart disease, and it did not lower the inflammation markers it was supposed to. 4,786 people took it or a dummy pill for about two years, and all took folate too. This is the trial that separates methotrexate from the...

     The New England Journal of Medicine, 2019 · 4,786 people

   • A year of methotrexate given before rheumatoid arthritis was diagnosed did not stop the arthritis from arriving. 236 adults with joint pain took part. They also got one steroid shot at the start. They did have less pain, stiffness and joint inflammation two years on. One region, and an early test of the idea.

     The Lancet, 2022 · 236 people

2. 02ResveratrolSupplementModerate. At least one finished study in people, and at least 100 people who took it. 14 completed trials, 403 people given it.7 reported

   203 people2 studies1 found nothing

   • found nothingThe longest and largest diabetes trial of resveratrol found nothing that counted. 192 patients took 40 mg, 500 mg or a dummy pill every day for six months. An inflammation marker fell further on resveratrol, but not by enough to call real. Weight, waist, blood pressure, blood sugar, insulin and a string of other...

     Pharmacological Research, 2016 · 192 people

   • This is the strongest good human result resveratrol has, and it rests on eleven men. Obese but otherwise healthy men took 150 mg a day for a month, and also spent a month on a dummy pill. Their resting metabolism slowed the way it does when people eat less. Liver fat, blood sugar, triglycerides, a liver enzyme and...

     Cell Metabolism, 2011 · 11 people

3. 03SomatropinBiologicLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 84 people given it.9 reported

   60 people1 study

   • Take growth hormone away from adults who need it and most things get worse. 60 adults with a pituitary shortage, treated for about ten years, were switched onto a dummy for four months. Their IGF-1 fell sharply. Two aspects of quality of life declined. Waists grew, deep belly fat rose, and cholesterol and an...

     Journal of Clinical Endocrinology and Metabolism, 2012 · 60 people

4. 04ThymalinPeptideModerate. At least one finished study in people, and at least 100 people who took it. 4 completed trials, 308 people given it.7 reported

   42 people1 study

   • A small early-pandemic trial reported faster recovery, and nobody died in either group. 42 patients got thymalin injections into the muscle for five days on top of standard care, and 50 got standard care alone, at one hospital in mid 2020. Lung scans worsened in 2 of the 42 treated against 5 of the 50 controls....

     Stem Cell Reviews and Reports, 2021 · 42 people

5. 05MIB-626SupplementModerate. At least one finished study in people, and at least 100 people who took it. 4 completed trials, 107 people given it.1 reported

   42 people1 study1 found nothing

   • found nothingThe tablet raised NAD in very sick patients and made no difference to them. 42 adults in hospital with COVID-19 and sudden kidney injury took MIB-626 or dummy tablets twice a day for two weeks. NAD in the blood roughly doubled by the end. Kidney blood tests came out the same in both groups. So did inflammation markers...

     FASEB BioAdvances, 2025 · 42 people

6. 06BrimapitidePeptideModerate. At least one finished study in people, and at least 100 people who took it. 4 completed trials, 510 people given it.

   20 people1 study

   • A small safety study in inflamed eyes, with nothing to compare it against. Twenty people who had inflammation inside the eye after surgery or injury got one injection under the surface of the eye. Seventeen side effects were recorded and all were judged unrelated to the drug. Almost none of the peptide reached the...

     Journal of Ocular Pharmacology and Therapeutics, 2015 · 20 people

7. 07BPC-157PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 31 people given it.10 reported

   number of people not given1 study

   • A company registered a study of a BPC-157 gummy, marked it completed, and has posted no results. 40 physically active adults were to take two gummies a day for eight weeks, 500 mcg of BPC-157 per serving. The main measurements were two blood markers of inflammation, hs-CRP and IL-6. Everybody was to get the gummy....

     ClinicalTrials.gov, Parlay Wellness, 2025 · number of people not given

8. 08Metformin plus rapamycinSmall moleculePreliminary. Studied in people, but no published study has had people take it. 2 registered with no result.2 reported

   number of people not given1 study

   • The one trial testing this pair cannot tell the two drugs apart. 30 people are enrolled by AgelessRx, an online company that prescribes these drugs, and it is no longer signing people up. Every group stacks rapamycin and metformin together with low-dose naltrexone, NAD+ up the nose, glutathione on the skin and a...

     ClinicalTrials.gov, 2025 · number of people not given

9. 09GDF15BiologicModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 313 people given it.3 reported

   53,902 people2 studies

   • GDF15 tracks with getting sick in general, not with any one disease. Researchers measured thousands of blood proteins in 53,026 UK adults and followed them for over 13 years. Higher GDF15 went with later diagnosis of more than twenty different long-term illnesses, and with having several at once. Much of the level was...

     Metabolism, 2025 · 53,026 people

   • Higher GDF15 marked out men who died sooner, but nobody was given anything. 876 Swedish men aged 35 to 80 gave a blood sample and were then followed for up to 14 years. Those with more GDF15 at the start were roughly three times as likely to die of any cause. The pattern held in a separate set of 324 twins. This is a...

     Aging Cell, 2010 · 876 people

10. 10KPVPeptideAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 2 animal studies, no human study.6 reported

    number of people not given0 studies

    • In mice with colitis, KPV carried in tiny particles sped up healing of the gut lining and lowered a swelling signal called TNF-alpha.

      Molecular Therapy, 2017 · number of people not given

11. 11ThymulinPeptideAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 1 animal study, no human study.1 reported

    number of people not given0 studies

    • In rats. A thymulin copy called PAT cut pain and swelling caused by a bacterial toxin, more so at higher doses.

      British Journal of Pharmacology, 2002 · number of people not given

12. 12KLOW blendBlendLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 13 people given it.11 reported

    number of people not given0 studies

    • In mice with gut inflammation. KPV given alone led to faster recovery, more weight regained and less inflammation in the colon. Nothing here tests KPV in a mix or in people.

      Inflammatory Bowel Diseases, 2008 · number of people not given

13. 13ChonlutenPeptideAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 2 lab studies, no human study.2 reported

    number of people not given0 studies

    • In a dish. In human immune cells, it cut the release of an inflammation signal after the cells met a bacterial toxin. The study was run with the institute that makes it, so it is not independent.

      International Journal of Molecular Sciences, 2022 · number of people not given

14. 14Ac-SDKPPeptideAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 1 animal study, no human study.2 reported

    number of people not given0 studies

    • In rats. It cut inflammation after brain injury.

      Journal of Neurosurgery, 2017 · number of people not given

15. 15OSK Partial ReprogrammingBiologicPreliminary. Studied in people, but no published study has had people take it. 1 registered with no result.5 reported

    number of people not given0 studies

    • In normally ageing mice, not ones bred to age fast, long stretches of partial reprogramming changed the kidney and skin. The longer the treatment ran, the bigger the change. Ageing clocks read younger. Genes for inflammation, worn-out cells and stress were turned down. The authors did not claim these mice lived longer.

      Nature Aging, 2022 · number of people not given

16. 16E5 Plasma FractionProcedureAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 4 animal studies, no human study.4 reported

    number of people not given0 studies

    • In rats, a fraction of young pig plasma made old organs look much younger on paper. The team first built and checked six tissue-age clocks for rat tissue, from 613 samples. Two of those also work in human tissue. After treatment, the tissue age of blood, heart and liver more than halved. A control centre in the brain...

      GeroScience, 2024 · number of people not given

17. 17ClusterinBiologicPreliminary. Studied in people, but no published study has had people take it. 2 human studies where nobody was given it, 1 registered with no result.4 reported

    number of people not given0 studies

    • In mice, with one human measurement inside it. Plasma from mice that chose to run, given to mice that did not, quietened inflammation genes in the brain. Protein screening showed a rise in a set of immune system brakes, clusterin among them. Clusterin injected into a vein stuck to the lining of brain blood vessels and...

      Nature, 2021 · number of people not given

18. 1825-HydroxycholesterolSmall moleculePreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.2 reported

    number of people not given0 studies

    • In mice. In mice with clogged arteries, 25-hydroxycholesterol made by immune cells made artery swelling and damage worse. It was also measured in human artery tissue, but only measured. This is a harm result in the same part of the body as the artery stiffness study.

      Circulation, 2023 · number of people not given

19. 19RisuteganibPeptideModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 263 people given it.

    number of people not given0 studies

    • In a dish. Retina support cells were made with mitochondria from 5 people with AMD and 3 without. They were treated with each drug for 48 hours at doses like those used in the eye. The AMD cells showed more signs of cell death at the start. The two drugs changed cell death, stress and swelling genes in different ways....

      Experimental Eye Research, 2021 · number of people not given

20. 2017-alpha-estradiolHormoneAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 4 animal studies, no human study.4 reported

    number of people not given0 studies

    • In mice, this study asked why these drugs mostly help males. It found that the drop in brain inflammation was itself different between males and females. That is part of an answer, not the whole answer.

      Aging Cell, 2017 · number of people not given

21. 21LamivudineSmall moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.3 reported

    number of people not given0 studies

    • In mice and in a dish. This is the paper that started the idea. In worn-out cells, jumping genes woke up and set off an immune alarm through loose DNA copies. Drugs that block the copying stopped it. Giving lamivudine to old mice turned down the alarm and cut inflammation in several body parts. It measured...

      Nature, 2019 · number of people not given

22. 22RuxolitinibSmall moleculeModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 309 people given it.

    number of people not given0 studies

    • In human cells in a dish and in old mice. Blocking the JAK pathway quieted the inflammatory signals from zombie cells. In old mice, 10 weeks of a JAK-blocking drug cut inflammation and helped them move better. There is no result in people.

      Proceedings of the National Academy of Sciences, 2015 · number of people not given

23. 23CartalaxPeptideAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 4 lab studies, no human study.8 reported

    number of people not given0 studies

    • In a dish. Aging cartilage cells gave off more aging and inflammation signals. Both Cartalax and a cartilage extract pushed those signals back toward normal. These were cells, not joints, and nobody measured a real health result.

      Advances in Gerontology, 2023 · number of people not given

24. 24ApelinPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 68 people given it.3 reported

    number of people not given0 studies

    • Mostly in mice. Mice missing apelin or its receptor lost a lot of muscle with age. Giving apelin signals back improved their muscle. A human part only watched people. In older people, muscle made less apelin with age, and more apelin went with more benefit from exercise. Nobody was given apelin. Public money paid for...

      Nature Medicine, 2018 · number of people not given