Peptide finder

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Pick as many as you like. The number on each one is how many people it has been measured in across the whole archive. So you can see where the evidence is before you choose.

1. 01PramlintidePeptideModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 684 people given it.

   204 people1 study

   • In people with obesity but no diabetes, pramlintide produced a small amount of weight loss. Two hundred and four of them took it or a dummy injection for four months, with the dose built up slowly. The drug group ended 3.6 kg lighter than the dummy group, about 3.7% of body weight. That is far less than newer weight...

     Journal of Clinical Endocrinology and Metabolism, 2007 · 204 people

2. 02GDF15BiologicModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 313 people given it.3 reported

   187 people2 studies

   • Blocking GDF15 put weight back on people with cancer who were wasting away. 187 patients with cancer wasting and high GDF15 were put into four groups. Three got the antibody at rising doses. One got a dummy shot. Shots came every four weeks, three times. By twelve weeks the drug groups had gained about 1.2 to 2.8...

     New England Journal of Medicine, 2024 · 187 people

   • The clearest picture of what GDF15 does in people comes from pregnancy. Most of the hormone in a pregnant woman's blood comes from the baby and the placenta, traced using a naturally tagged version of it. Women whose genes gave them low GDF15 before pregnancy were more likely to suffer severe pregnancy sickness. Women...

     Nature, 2024 · number of people not given

3. 03DapiglutidePeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 54 people given it.

   54 people1 study1 found nothing

   • found nothingThis early weight loss trial missed its target. 54 adults with obesity in Denmark were split by chance between two doses of dapiglutide and a dummy injection, weekly for three months. Nobody was asked to change their diet or exercise. The higher dose took off about two percent more body weight than the dummy, which is...

     EClinicalMedicine, 2026 · 54 people

4. 04GhrelinPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 27 people given it.1 reported

   27 people2 studies

   • Put straight into the blood, the hormone set off a big release of growth hormone and people coped with it. 18 men got one of two doses or a dummy, and nobody involved knew which. Both doses drove growth hormone up strongly. The body cleared half of the active hormone in about 9 to 13 minutes, which is very fast....

     European Journal of Endocrinology, 2004 · 18 people

   • Giving people ghrelin made them hungry, and they ate more. Nine healthy volunteers got the hormone through a drip, then sat down to a buffet. They ate roughly a quarter more food than they otherwise would. This was the first time a hormone circulating in the blood had been shown to drive eating in people. Nine is a...

     Journal of Clinical Endocrinology and Metabolism, 2001 · 9 people

5. 05ForskolinSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 53 people given it.5 reported

   23 people1 study1 found nothing

   • found nothingThe same supplement was tested in women and it did not work. 23 mildly overweight women took a 10 percent Coleus forskohlii extract twice a day or a dummy for 12 weeks, seven on the extract. Fat mass, lean mass and body fat percentage came out the same in both groups. Slight leanings toward less weight gain were too...

     Journal of the International Society of Sports Nutrition, 2005 · 23 people

6. 06OxyntomodulinPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 13 people given it.

   13 people3 studies1 found nothing

   • found nothingGiven the hormone, people ate less at the next meal. 13 healthy volunteers had sessions on oxyntomodulin and on a dummy drip, and nobody knew which was which. Food eaten at a buffet fell by about a fifth, and food over the next 12 hours fell by about a tenth. Their hunger hormone went down. Nobody felt sick and food...

     Journal of Clinical Endocrinology and Metabolism, 2003 · 13 people

   • Four weeks of shots before meals took weight off. People with extra weight gave themselves oxyntomodulin three times a day before eating, or a dummy shot. They lost 2.3 kg, against 0.5 kg on the dummy, roughly 0.45 kg a week. How much they ate at a test meal fell by a quarter at the start and by a third by the end....

     Diabetes, 2005 · number of people not given

   • People ate less, and they did not burn more. 15 healthy young men got oxyntomodulin, GLP-1, glucagon, the last two together, or salt water before a meal, on separate days. Every hormone cut how much they ate, by about the same amount. Giving GLP-1 and glucagon together added nothing. Oxygen use, which is how energy...

     Journal of Clinical Endocrinology and Metabolism, 2015 · number of people not given

7. 07GHRP-2PeptideModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 102 people given it.7 reported

   17 people2 studies1 found nothing

   • found nothingOral GHRP-2 made children hungrier and did not change their build. Ten children with a growth hormone deficiency swallowed it twice a day for a year. Seven of the ten reported a clear rise in appetite in the first six months. Their weight for height barely moved across the year, and the authors report that change as...

     Journal of Pediatric Endocrinology and Metabolism, 2003 · 10 people

   • GHRP-2 makes people eat more. Seven lean men were given it as a drip and then offered food freely. They ate about a third more than they otherwise would, and growth hormone rose sharply at the same time. That appetite push is a real effect of the drug, not a side note. Seven men is a very small group, and they were...

     Journal of Clinical Endocrinology and Metabolism, 2005 · 7 people

8. 08Melanotan II with PT-141BlendLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 10 people given it.7 reported

   10 people1 study

   • Melanotan II caused erections in most of a very small group of men. Ten men whose erection trouble had no physical cause each took the peptide and a dummy shot on separate days. Nobody knew which was which on the day. Eight of the ten got a clear erection on the drug. A monitor recorded firmness above four fifths of...

     Journal of Urology, 1998 · 10 people

9. 09TERN-601Small moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 3 people given it.3 reported

   3 people1 study

   • TERN-601 caused weight loss, then ended its own program with liver damage. There were two studies, one for 28 days and one for 12 weeks, both against a dummy pill. In the first, every dose led to more weight loss than the dummy pill, with less hunger and slower stomach emptying. In the second, doses of 500 mg and up...

     Obesity, 2026 · 3 people

10. 10LeptinBiologicModerate. At least one finished study in people, and at least 100 people who took it. 6 completed trials, 844 people given it.5 reported

    3 people1 study

    • Give leptin to the rare children who have none and it transforms them. Three children born unable to make leptin were injected daily for up to four years. Appetite fell, fat mass fell, insulin and blood fats came back towards normal, and puberty arrived at the right age. Immune cells that had been depleted recovered...

      Journal of Clinical Investigation, 2002 · 3 people

11. 11MibavademabBiologicLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 1 person given it.

    1 people1 study1 found nothing

    • found nothingThe antibody only worked in people who were already short of leptin. In an early study in people, compared with a dummy shot, it was well tolerated. In the authors' words, it reduced body weight over twelve weeks in people with low leptin in the blood, and had no effect on weight in people whose leptin was higher. One...

      Science Translational Medicine, 2023 · 1 people

12. 12Peptide YYPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 12 people given it.3 reported

    number of people not given2 studies1 found nothing

    • Two gut hormones together cut eating more than either one alone. Twelve overweight or obese volunteers each tried the combination, the single hormones and a dummy infusion, in turn, without knowing which. At a test meal during the combined infusion they ate about 43% less than on salt water, and less than on either...

      Diabetes, 2010 · number of people not given

    • found nothingCopying the hormone mix that follows stomach bypass surgery cut food intake by about a third. Obese volunteers wore a pump under the skin for about ten and a half hours, delivering three gut hormones at post-surgery levels, or a dummy infusion. Each person tried both, in turn, and did not know which was running. They...

      Journal of Clinical Endocrinology and Metabolism, 2017 · number of people not given

13. 13GLP-1PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 8 people given it.1 reported

    number of people not given1 study

    • The hormone your own gut makes does what the drugs built from it do, only briefly. Adults with obesity injected native GLP-1 before meals for five days, and also spent a period on a dummy, with nobody knowing which. Food eaten at each meal fell by about 15 percent and they lost 0.55 kg. Food leaving the stomach more...

      British Journal of Nutrition, 2004 · number of people not given

14. 14TesofensineSmall moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.8 reported

    number of people not given1 study

    • The weight came off because people ate less, not because the drug burned anything. This was a smaller study run inside the main trial, looking at hunger. People taking tesofensine reported weaker appetite and took in less food. That is the mechanism behind the weight loss reported in the main result. Appetite was...

      Obesity, 2012 · number of people not given

15. 15BofanglutidePeptideModerate. At least one finished study in people, and at least 100 people who took it. 5 completed trials, 750 people given it.4 reported

    number of people not given1 study

    • This study measured how the drug behaves in blood, not whether it helps anyone. Healthy American and Chinese adults took steadily rising doses. The body took about seven days to clear half of it in both groups, and the amount reaching the blood was near identical, so no difference between the two populations showed...

      Diabetes, Obesity and Metabolism, 2025 · number of people not given

16. 16CotadutidePeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 6 completed trials, 1,221 people given it.

    number of people not given1 study1 found nothing

    • found nothingPeople lost weight on cotadutide because they ate less, not because they burned more. This small study followed 12 people on the drug and 7 on a dummy for six weeks. The drug group lost four percent of their body weight against one and a half percent on the dummy. They ate far less food. Energy burned, measured...

      Diabetes, Obesity and Metabolism, 2024 · number of people not given

17. 17BGM0504PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 64 people given it.

    40 people1 study

    • Healthy volunteers, and the weight figures belong to healthy volunteers. 40 healthy Chinese people took a single 2.5 mg dose, then weekly doses rising to 5, 10 and 15 mg. The amount in the blood rose in step with the dose across that range. Weight fell 3.24, 6.26, 7.09 and 8.30 percent at the four doses. Vomiting,...

      Diabetes, Obesity and Metabolism, 2025 · 40 people

18. 18Sermorelin / GHRPBlendLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 56 people given it.9 reported

    7 people1 study

    • The hunger is not a rumour, it was measured. Seven lean men given this peptide ate about a third more when left to help themselves, alongside a large rise in growth hormone. Seven men is a very small study and one free meal is easy to sway. Even so, appetite is the effect people report most and the one that most often...

      Journal of Clinical Endocrinology and Metabolism, 2005 · 7 people

19. 19SetmelanotidePeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 38 people given it.4 reported

    number of people not given1 study

    • In rare genetic forms of obesity most patients lost serious weight, and there was nobody to compare them against. After about a year, 8 of 10 people with one gene fault and 5 of 11 with the other had lost at least a tenth of their body weight. Reported hunger fell by roughly a third in one group and nearly half in the...

      The Lancet Diabetes & Endocrinology, 2020 · number of people not given

20. 20ARD-101Small moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 20 people given it.3 reported

    number of people not given1 study

    • ARD-101 made people less hungry. The headline weight loss belongs to mice. Adults with obesity took 200 mg twice a day for 28 days, or a dummy pill. They lost 0.8 kg more than the dummy group by day 28, and 1.3 kg by the end. They also reported less hunger and fewer food cravings. The bigger weight loss in the paper...

      Molecular Metabolism, 2026 · number of people not given

21. 21CJC-1295 with GHRP-2BlendLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, none stating how many people.8 reported

    number of people not given1 study

    • GHRP-2 makes healthy men hungrier. That is the drug itself at work, not a side story. It works on the same switch as the hunger hormone, and does the same job. That matters because the hunger comes with the product. Which GHRP a seller puts in the vial decides whether you spend the cycle fighting hunger. This was...

      Journal of Clinical Endocrinology and Metabolism, 2005 · number of people not given

22. 22CJC-1295 with ipamorelin and GHRP-2BlendModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 117 people given it.5 reported

    number of people not given1 study

    • GHRP-2 makes healthy men eat more, and that matters here more than anywhere. Ipamorelin was picked from this drug family because it lifts growth hormone without dragging hunger along. Put GHRP-2 in the same vial and the hunger comes right back. The one thing the ipamorelin in this blend was chosen for is cancelled by...

      Journal of Clinical Endocrinology and Metabolism, 2005 · number of people not given

23. 23Sermorelin with GHRP-2 and GHRP-6BlendLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 9 people given it.6 reported

    number of people not given1 study

    • GHRP-2 makes healthy men eat more, the same way the hunger hormone ghrelin does. This vial holds two peptides that press that same hunger switch. Their effects there add up. They do not cancel out. So the hunger is not a quirk of one ingredient that the other might balance. It is the expected result of stacking two...

      Journal of Clinical Endocrinology and Metabolism, 2005 · number of people not given

24. 24IGF-1 LR3PeptidePreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.8 reported

    number of people not given0 studies

    • In pigs. It went the wrong way. Four days of IGF-1 LR3 lowered the pigs' weight gain, how much they ate, their growth hormone and their own IGF-1.

      Journal of Endocrinology, 1997 · number of people not given