E5 Plasma Fraction vs Young Plasma Infusion
Written by Aaron CuhaReviewed Sep 2026
The short answer
A purified plasma fraction from young pigs, next to whole plasma from young human donors. In old rats, the fraction more than halved the DNA based age of blood, heart and liver. No human has received the fraction. The one trial of the young plasma infusion enrolled 18 Alzheimer patients and was sized only to check safety.
- E5 Plasma Fraction people
- 0
- E5 Plasma Fraction nulls
- 0
- Young Plasma Infusion people
- 18
- Young Plasma Infusion nulls
- 0
Dose
No human dose established
No published study on this page has given this compound to people and reported a result.
4 animal studies, no human study
Dose
Approved medicine. No human dose established for unlabelled uses
Labeled amounts sit on the prescribing information. This page records what trials measured, not a personal dose.
Plasma, the liquid part of blood, is a licensed blood product. Doctors use it for set medical reasons, such as blood clotting problems and plasma exchange. Giving it by drip for ageing, memory loss or diseases that kill brain cells is not an approved use. The FDA warned the public about clinics selling it on 19 February 2019.
First-hand reports are counted on each profile and never added together. This page sets two published records side by side. It does not pick a winner.
Column A
E5 Plasma FractionE5 (purified plasma fraction from young pigs)
A cleaned-up part of the blood plasma of young pigs, given to old rats. It more than halved the tissue age of their blood, heart and liver. No person has ever received it.
Column B
Young Plasma InfusionYoung donor plasma infusion (transfusion of plasma from young adult donors)
Plasma from donors aged 18 to 30, dripped into older people. The one proper trial took 18 people with Alzheimer disease and was built to check safety, not benefit. The FDA published a public warning about clinics selling it in February 2019.
Side by side, on the facts we can check
| What we compare | E5 Plasma Fraction | Young Plasma Infusion |
|---|---|---|
| Category | Longevity | Longevity |
| FDA status | Not approved anywhere. ClinicalTrials.gov lists no human study of a plasma extract from pigs for any ageing use. This is a research product only. | Plasma, the liquid part of blood, is a licensed blood product. Doctors use it for set medical reasons, such as blood clotting problems and plasma exchange. Giving it by drip for ageing, memory loss or diseases that kill brain cells is not an approved use. The FDA warned the public about clinics selling it on 19 February 2019. |
| Half-life | Not reported | Not reported |
| Molecular weight | Not reported | Not reported |
| How it works | Not worked out, in any species. The paper measures outcomes, mainly tissue-age clock readings and organ function markers. It does not say which part of the fraction does what. Nobody has named the active ingredient. That is the usual position for whole plasma and plasma fractions. It is also why the serious drug work in this field is on single named factors like TIMP2, platelet factor 4 and Gpld1, rather than on mixtures. | Not worked out in people. In mice, plasma from young animals carries factors including TIMP2, platelet factor 4, Gpld1 and clusterin. Those improve how the memory centre of the brain adapts, how new brain cells form and how the animals learn. Old plasma carries factors including CCL11 and beta-2 microglobulin, which do the opposite. No study in people has found which part of young plasma, if any, does anything. The Stanford trial did not try to. Plasma is a complex mixture with clotting factors, antibodies and hundreds of proteins. That alone makes it hard to read, even when it is given. |
| Studies in people | 0 | 3 |
| Evidence | Animal or lab only: 4 animal studies, no human study | Limited: 1 completed trial, 18 people given it |
| Legal status, US | Research use only; not approved | Licensed blood product; giving it by drip for ageing is an unapproved use |
Frequently asked questions
What is the difference between E5 Plasma Fraction and Young Plasma Infusion?
E5 Plasma Fraction: A cleaned-up part of the blood plasma of young pigs, given to old rats. It more than halved the tissue age of their blood, heart and liver. No person has ever received it. Young Plasma Infusion: Plasma from donors aged 18 to 30, dripped into older people. The one proper trial took 18 people with Alzheimer disease and was built to check safety, not benefit. The FDA published a public warning about clinics selling it in February 2019.
Which has stronger research evidence, E5 Plasma Fraction or Young Plasma Infusion?
Each compound gets a band worked out from facts we counted, with the math shown. E5 Plasma Fraction is Animal or lab only (4 animal studies, no human study). Young Plasma Infusion is Limited (1 completed trial, 18 people given it). That counts how much has been done in people. It does not rate whether either one works, and neither one is called the winner.
Are E5 Plasma Fraction and Young Plasma Infusion FDA-approved?
E5 Plasma Fraction: Not approved anywhere. ClinicalTrials.gov lists no human study of a plasma extract from pigs for any ageing use. This is a research product only.. Young Plasma Infusion: Plasma, the liquid part of blood, is a licensed blood product. Doctors use it for set medical reasons, such as blood clotting problems and plasma exchange. Giving it by drip for ageing, memory loss or diseases that kill brain cells is not an approved use. The FDA warned the public about clinics selling it on 19 February 2019..
Reviewed Sep 2026. This page puts two published records side by side. It is for learning, and it is not medical advice. When this site shows a dose, it is the dose a trial or a clinic actually used, or what people say they did, with the source attached. None of it tells you what to take.