Head to head
E5 Plasma Fraction against Young Plasma Infusion
A purified plasma fraction from young pigs that more than halved epigenetic age in blood, heart and liver in old rats, next to whole plasma from young human donors. No human has received the fraction, and the one randomised trial of the infusion enrolled 18 Alzheimer patients and was powered for safety.
Column A
E5 Plasma FractionE5 (purified plasma fraction from young pigs)
A purified fraction of plasma from young pigs, given to old rats, which more than halved epigenetic age in blood, heart and liver. No human has received it.
Column B
Young Plasma InfusionYoung donor plasma infusion (transfusion of plasma from young adult donors)
Plasma from donors aged 18 to 30 infused into older people. The one randomised trial enrolled 18 patients with Alzheimer disease and was powered for safety, not effect. FDA published a consumer warning about clinics selling it in February 2019.
Side by side, on the facts we can check
| Attribute | E5 Plasma Fraction | Young Plasma Infusion |
|---|---|---|
| Category | Longevity | Longevity |
| FDA status | Not approved anywhere. No registered human trial of a porcine plasma fraction for an ageing indication exists on ClinicalTrials.gov. This is a research preparation. | Plasma is a licensed blood component with defined clinical indications in coagulation and plasma exchange. Infusion for ageing, memory loss or neurodegeneration is not an approved use. FDA published a consumer warning about clinics selling it on 19 February 2019. |
| Half-life | Not reported | Not reported |
| Molecular weight | Not reported | Not reported |
| Mechanism | Not established, in any species. The paper measures outcomes, chiefly epigenetic clock readings and organ function markers, rather than identifying which component of the fraction acts on what. The active constituent has not been named. That is the ordinary position for whole-plasma and plasma-fraction interventions, and it is why the field's serious drug work is on individual identified factors such as TIMP2, platelet factor 4 and Gpld1 rather than on mixtures. | Not established in humans. In mice, plasma from young animals carries factors including TIMP2, platelet factor 4, Gpld1 and clusterin that improve hippocampal plasticity, neurogenesis and cognition, while old plasma carries factors including CCL11 and beta-2 microglobulin that impair them. No human study has identified which component of young plasma, if any, does anything, and the PLASMA trial did not attempt to. Plasma is a complex biological mixture containing clotting factors, antibodies and hundreds of proteins, which is a reason the intervention is difficult to interpret even when it is given. |
| Human studies cited | 0 | 3 |
| Legal status, US | Research use only; not approved | Licensed blood component; infusion for ageing is an unapproved use |
Frequently asked questions
What is the difference between E5 Plasma Fraction and Young Plasma Infusion?
E5 Plasma Fraction: A purified fraction of plasma from young pigs, given to old rats, which more than halved epigenetic age in blood, heart and liver. No human has received it. Young Plasma Infusion: Plasma from donors aged 18 to 30 infused into older people. The one randomised trial enrolled 18 patients with Alzheimer disease and was powered for safety, not effect. FDA published a consumer warning about clinics selling it in February 2019.
Which has stronger research evidence, E5 Plasma Fraction or Young Plasma Infusion?
This database does not grade compounds. It counts what was run in people: 0 of the 4 studies cited on the E5 Plasma Fraction profile were human work, against 3 of 6 for Young Plasma Infusion. Those counts are of our own citation lists and understate any larger literature, and neither is a recommendation.
Are E5 Plasma Fraction and Young Plasma Infusion FDA-approved?
E5 Plasma Fraction: Not approved anywhere. No registered human trial of a porcine plasma fraction for an ageing indication exists on ClinicalTrials.gov. This is a research preparation.. Young Plasma Infusion: Plasma is a licensed blood component with defined clinical indications in coagulation and plasma exchange. Infusion for ageing, memory loss or neurodegeneration is not an approved use. FDA published a consumer warning about clinics selling it on 19 February 2019..
Reviewed Sep 2026. This page sets two published records side by side. It is educational, it is not medical advice, and it contains no dosing protocols or recommendations for personal use.