Teduglutide vs Apraglutide
Written by Aaron CuhaReviewed Sep 2026
The short answer
The approved daily GLP-2 copy for short bowel syndrome, against a once weekly one still in development. For a patient injecting every day, the time between doses is the point of the comparison. The trials behind each are not the same size.
- Teduglutide people
- 83
- Teduglutide nulls
- 0
- Apraglutide people
- 0
- Apraglutide nulls
- 0
Dose
Approved medicine. No human dose established for unlabelled uses
Labeled amounts sit on the prescribing information. This page records what trials measured, not a personal dose.
FDA-approved (Gattex) for short bowel syndrome
Dose
No human dose established
Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose.
2 completed trials, 0 people given it
First-hand reports are counted on each profile and never added together. This page sets two published records side by side. It does not pick a winner.
Column A
TeduglutideTeduglutide (GLP-2 analogue)
An FDA-approved shot that helps the gut grow in short bowel syndrome, so people need less feeding through a vein.
Column B
ApraglutideApraglutide (FE 203799), once-weekly GLP-2 analogue
A once a week version of GLP-2 for short bowel syndrome, where the approved drug, teduglutide, needs a daily shot. In small studies it helped the gut absorb more fluid.
Side by side, on the facts we can check
| What we compare | Teduglutide | Apraglutide |
|---|---|---|
| Category | Metabolic | Healing & Recovery |
| FDA status | FDA-approved (Gattex) for short bowel syndrome | Investigational for short bowel syndrome. Not approved at the time of this review. |
| Half-life | ~2 hours | Long-acting, engineered for once-weekly subcutaneous dosing. No specific figure resolved in the sources loaded. |
| Molecular weight | 3,752.1 Da | Modified GLP-2 analogue peptide. No mass asserted; no source loaded states one. |
| How it works | It switches on GLP-2 receptors in the gut. That makes the gut lining grow and absorb food better. | It is a long acting copy of glucagon-like peptide-2, a 33 amino acid hormone released by cells in the gut. GLP-2 makes the gut lining grow. The finger-like folds that absorb food get taller, and the pits between them get deeper. It also slows the stomach and gut, and boosts blood flow to the gut. Together these let the gut absorb more. Changes to its structure make it last long enough for a weekly shot, where teduglutide needs a daily one. |
| Studies in people | 3 | 2 |
| Evidence | Limited: 2 completed trials, 83 people given it | Limited: 2 completed trials, none stating how many people |
| Legal status, US | FDA-approved, prescription only | Investigational, not approved |
Frequently asked questions
What is the difference between Teduglutide and Apraglutide?
Teduglutide: An FDA-approved shot that helps the gut grow in short bowel syndrome, so people need less feeding through a vein. Apraglutide: A once a week version of GLP-2 for short bowel syndrome, where the approved drug, teduglutide, needs a daily shot. In small studies it helped the gut absorb more fluid.
Which has stronger research evidence, Teduglutide or Apraglutide?
Each compound gets a band worked out from facts we counted, with the math shown. Teduglutide is Limited (2 completed trials, 83 people given it). Apraglutide is Limited (2 completed trials, none stating how many people). That counts how much has been done in people. It does not rate whether either one works, and neither one is called the winner.
Are Teduglutide and Apraglutide FDA-approved?
Teduglutide: FDA-approved (Gattex) for short bowel syndrome. Apraglutide: Investigational for short bowel syndrome. Not approved at the time of this review..
Related posts
Blog articles that cover Teduglutide or Apraglutide, newest first.
Reviewed Sep 2026. This page puts two published records side by side. It is for learning, and it is not medical advice. When this site shows a dose, it is the dose a trial or a clinic actually used, or what people say they did, with the source attached. None of it tells you what to take.