Young Plasma Infusion vs Plasma Dilution
Written by Aaron CuhaReviewed Sep 2026
The short answer
The experiment that asked whether the young part of young blood does anything. In mice, replacing half the plasma with salt water plus albumin, adding nothing young, matched the effects credited to young blood.
- Young Plasma Infusion people
- 18
- Young Plasma Infusion nulls
- 0
- Plasma Dilution people
- 42
- Plasma Dilution nulls
- 0
Dose
Approved medicine. No human dose established for unlabelled uses
Labeled amounts sit on the prescribing information. This page records what trials measured, not a personal dose.
Plasma, the liquid part of blood, is a licensed blood product. Doctors use it for set medical reasons, such as blood clotting problems and plasma exchange. Giving it by drip for ageing, memory loss or diseases that kill brain cells is not an approved use. The FDA warned the public about clinics selling it on 19 February 2019.
Dose
No human dose established
Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose.
2 completed trials, 42 people given it
First-hand reports are counted on each profile and never added together. This page sets two published records side by side. It does not pick a winner.
Column A
Young Plasma InfusionYoung donor plasma infusion (transfusion of plasma from young adult donors)
Plasma from donors aged 18 to 30, dripped into older people. The one proper trial took 18 people with Alzheimer disease and was built to check safety, not benefit. The FDA published a public warning about clinics selling it in February 2019.
Column B
Plasma DilutionPlasma dilution (neutral blood exchange with saline and albumin)
The mouse experiment that asked whether young blood is needed at all. Swapping half the plasma for salt water plus albumin, adding nothing young, matched what people credit to young blood.
Side by side, on the facts we can check
| What we compare | Young Plasma Infusion | Plasma Dilution |
|---|---|---|
| Category | Longevity | Longevity |
| FDA status | Plasma, the liquid part of blood, is a licensed blood product. Doctors use it for set medical reasons, such as blood clotting problems and plasma exchange. Giving it by drip for ageing, memory loss or diseases that kill brain cells is not an approved use. The FDA warned the public about clinics selling it on 19 February 2019. | Not approved anywhere as an ageing treatment, and no human study is registered under this name. A closely related procedure in people, therapeutic plasma exchange, is an established medical treatment used for its own set of conditions. |
| Half-life | Not reported | Not reported |
| Molecular weight | Not reported | Not reported |
| How it works | Not worked out in people. In mice, plasma from young animals carries factors including TIMP2, platelet factor 4, Gpld1 and clusterin. Those improve how the memory centre of the brain adapts, how new brain cells form and how the animals learn. Old plasma carries factors including CCL11 and beta-2 microglobulin, which do the opposite. No study in people has found which part of young plasma, if any, does anything. The Stanford trial did not try to. Plasma is a complex mixture with clotting factors, antibodies and hundreds of proteins. That alone makes it hard to read, even when it is given. | Shown in mice only. The idea is that plasma carries proteins that feed back on their own production and on many signal routes. Watering them down resets those routes, and the change to gene activity lasts rather than fading as the levels come back. Albumin was added to the fluid to put back what salt water alone would have washed out. The authors say the added albumin does not look like the whole story. They point out that albumin levels do not fall with age and do not rise after the swap. None of this has been shown in a person. |
| Studies in people | 3 | 2 |
| Evidence | Limited: 1 completed trial, 18 people given it | Limited: 2 completed trials, 42 people given it |
| Legal status, US | Licensed blood product; giving it by drip for ageing is an unapproved use | Investigational, not approved |
Frequently asked questions
What is the difference between Young Plasma Infusion and Plasma Dilution?
Young Plasma Infusion: Plasma from donors aged 18 to 30, dripped into older people. The one proper trial took 18 people with Alzheimer disease and was built to check safety, not benefit. The FDA published a public warning about clinics selling it in February 2019. Plasma Dilution: The mouse experiment that asked whether young blood is needed at all. Swapping half the plasma for salt water plus albumin, adding nothing young, matched what people credit to young blood.
Which has stronger research evidence, Young Plasma Infusion or Plasma Dilution?
Each compound gets a band worked out from facts we counted, with the math shown. Young Plasma Infusion is Limited (1 completed trial, 18 people given it). Plasma Dilution is Limited (2 completed trials, 42 people given it). That counts how much has been done in people. It does not rate whether either one works, and neither one is called the winner.
Are Young Plasma Infusion and Plasma Dilution FDA-approved?
Young Plasma Infusion: Plasma, the liquid part of blood, is a licensed blood product. Doctors use it for set medical reasons, such as blood clotting problems and plasma exchange. Giving it by drip for ageing, memory loss or diseases that kill brain cells is not an approved use. The FDA warned the public about clinics selling it on 19 February 2019.. Plasma Dilution: Not approved anywhere as an ageing treatment, and no human study is registered under this name. A closely related procedure in people, therapeutic plasma exchange, is an established medical treatment used for its own set of conditions..
Reviewed Sep 2026. This page puts two published records side by side. It is for learning, and it is not medical advice. When this site shows a dose, it is the dose a trial or a clinic actually used, or what people say they did, with the source attached. None of it tells you what to take.