Head to head
Young Plasma Infusion against Plasma Dilution
The experiment that asked whether the young part of young blood is doing anything. Replacing half the plasma with saline plus albumin, adding nothing young, matched the effects attributed to young blood in mice.
Column A
Young Plasma InfusionYoung donor plasma infusion (transfusion of plasma from young adult donors)
Plasma from donors aged 18 to 30 infused into older people. The one randomised trial enrolled 18 patients with Alzheimer disease and was powered for safety, not effect. FDA published a consumer warning about clinics selling it in February 2019.
Column B
Plasma DilutionPlasma dilution (neutral blood exchange with saline and albumin)
The mouse experiment that asked whether young blood is necessary at all. Replacing half the plasma with saline plus albumin, adding nothing young, matched the effects attributed to young blood.
Side by side, on the facts we can check
| Attribute | Young Plasma Infusion | Plasma Dilution |
|---|---|---|
| Category | Longevity | Longevity |
| FDA status | Plasma is a licensed blood component with defined clinical indications in coagulation and plasma exchange. Infusion for ageing, memory loss or neurodegeneration is not an approved use. FDA published a consumer warning about clinics selling it on 19 February 2019. | Not approved anywhere as an ageing intervention, and not registered as a human trial under this name. The closely related human procedure, therapeutic plasma exchange, is an established medical treatment with its own indications. |
| Half-life | Not reported | Not reported |
| Molecular weight | Not reported | Not reported |
| Mechanism | Not established in humans. In mice, plasma from young animals carries factors including TIMP2, platelet factor 4, Gpld1 and clusterin that improve hippocampal plasticity, neurogenesis and cognition, while old plasma carries factors including CCL11 and beta-2 microglobulin that impair them. No human study has identified which component of young plasma, if any, does anything, and the PLASMA trial did not attempt to. Plasma is a complex biological mixture containing clotting factors, antibodies and hundreds of proteins, which is a reason the intervention is difficult to interpret even when it is given. | Established in mice only. The proposal is that plasma contains autoregulatory proteins whose concentrations feed back on their own production and on multiple signalling pathways, so that diluting them resets those pathways and produces durable transcriptional changes rather than a transient concentration drop. Albumin was added to the exchange fluid to replace what saline alone would have diluted, and the authors state that ectopically added albumin does not appear to be the sole determinant of the effect, noting that albumin levels do not fall with age and do not rise after exchange. The mechanism has not been demonstrated in a person. |
| Human studies cited | 3 | 2 |
| Legal status, US | Licensed blood component; infusion for ageing is an unapproved use | Investigational, not approved |
Frequently asked questions
What is the difference between Young Plasma Infusion and Plasma Dilution?
Young Plasma Infusion: Plasma from donors aged 18 to 30 infused into older people. The one randomised trial enrolled 18 patients with Alzheimer disease and was powered for safety, not effect. FDA published a consumer warning about clinics selling it in February 2019. Plasma Dilution: The mouse experiment that asked whether young blood is necessary at all. Replacing half the plasma with saline plus albumin, adding nothing young, matched the effects attributed to young blood.
Which has stronger research evidence, Young Plasma Infusion or Plasma Dilution?
This database does not grade compounds. It counts what was run in people: 3 of the 6 studies cited on the Young Plasma Infusion profile were human work, against 2 of 4 for Plasma Dilution. Those counts are of our own citation lists and understate any larger literature, and neither is a recommendation.
Are Young Plasma Infusion and Plasma Dilution FDA-approved?
Young Plasma Infusion: Plasma is a licensed blood component with defined clinical indications in coagulation and plasma exchange. Infusion for ageing, memory loss or neurodegeneration is not an approved use. FDA published a consumer warning about clinics selling it on 19 February 2019.. Plasma Dilution: Not approved anywhere as an ageing intervention, and not registered as a human trial under this name. The closely related human procedure, therapeutic plasma exchange, is an established medical treatment with its own indications..
Reviewed Sep 2026. This page sets two published records side by side. It is educational, it is not medical advice, and it contains no dosing protocols or recommendations for personal use.