Legal status by country
Is Alpha-ketobutyrate legal?
Written by Aaron CuhaReviewed Sep 2026
How Alpha-ketobutyrate is classified in the United States, United Kingdom, Australia and Canada, side by side. Each country has its own page with a direct answer, the regulator's approval status and what the classification means in practice.
All four countries, side by side
| Attribute | United States · FDA | United Kingdom · MHRA | Australia · TGA | Canada · Health Canada |
|---|---|---|---|---|
| Status | Not approved | Not approved | Not approved | Not approved |
| Classification | Sold as a supplement | Sold as a supplement | Available as a supplement / complementary medicine | Sold as a supplement |
| Note | Sold in a small number of longevity products. No approved indication and no human supplementation trial located. Do not confuse it with alpha-ketoglutarate, a different molecule with its own separate evidence base. | No licensed medicinal indication; availability as a food supplement is limited. | None recorded | None recorded |
US FDA status: Not an approved drug and not an established dietary ingredient with a defined intake. Sold in a small number of longevity supplement products, generally as a salt.. Reviewed Sep 2026.
Related compounds
General information current as of Sep 2026, not legal advice. Classifications change; confirm with the regulator or a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships.