Legal status by country
Is Apelin legal?
Written by Aaron CuhaReviewed Sep 2026
How Apelin is classified in the United States, United Kingdom, Australia and Canada, side by side. Each country has its own page with a direct answer, the regulator's approval status and what the classification means in practice.
All four countries, side by side
| Attribute | United States · FDA | United Kingdom · MHRA | Australia · TGA | Canada · Health Canada |
|---|---|---|---|---|
| Status | Not approved | Not approved | Not approved | Not approved |
| Classification | Not approved; research use only | Not licensed | Not approved | Not approved |
| Note | Apelin-13 is an endogenous peptide sold in synthetic form by research suppliers. No approved product exists; recombinant material sold "for research" is an unapproved drug if used in a person. | No licensed product. | No TGA-registered product. | No Health Canada approved product. |
US FDA status: Not FDA-approved. No apelin peptide or APJ receptor agonist is approved anywhere. Novartis's APJ agonist CLR325 completed a 26-patient phase 2 safety study in heart failure in 2019; native apelin has been given to people only in acute physiology studies.. Reviewed Sep 2026.
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General information current as of Sep 2026, not legal advice. Classifications change; confirm with the regulator or a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships.