Legal status · United States
Is Apigenin legal in the United States?
Written by Aaron CuhaReviewed Sep 2026
Direct answer
Apigenin can be sold in the United States as a supplement or cosmetic ingredient. Its legal category is "Sold as a supplement". That is not approval as a drug. FDA has not checked any health claim made for it. Versions you inject, and "research use only" versions, fall outside supplement rules, so that label does not make them legal to use in people. On the evidence, no completed trial in people is cited on its profile (1 human record with no result or no dose given).
- People given it
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- Found nothing
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Legal category
Sold as a supplement
Sold as a supplement, and found in ordinary foods including parsley, celery and chamomile. No approved health claim about NAD or ageing.
Reviewed Sep 2026. This is a legal category, not legal advice.
A "research use only" label on a vial does not make it legal to use on people.
Apigenin in the United States at a glance
| Legal category | Sold as a supplement |
|---|---|
| Note | Sold as a supplement, and found in ordinary foods including parsley, celery and chamomile. No approved health claim about NAD or ageing. |
| FDA approval status | Found naturally in common foods, and sold over the counter as a supplement. Not an approved drug for any use, and no health claim about NAD, CD38 or ageing has been approved. |
| Studies in people | 1 of 4 sources on the profile |
| Reviewed | Sep 2026 |
The legal category and note come from the Apigenin profile. We checked them against U.S. Food and Drug Administration (FDA) listings on the reviewed date.
What this means
- 01
Apigenin can be sold in the United States as a supplement, food or cosmetic ingredient, under the legal category above. It has no approval as a drug.
- 02
Being sold as a supplement means FDA has not checked any health claim. The makers are responsible for safety and labels, and quality varies from product to product.
- 03
Versions you inject, and "research use only" versions, are not supplements. That label does not make them legal to use in people, and anything you inject falls under the rules for medicines.
What Apigenin is
Sold as a way to protect your NAD by blocking CD38, an enzyme that uses NAD up. That rests on one 2013 paper in cells and obese mice. No study in people has ever checked whether apigenin changes CD38 or NAD. After a big serving of parsley, blood levels in people only reach a tiny amount.
Apigenin has a growing spot in NAD marketing. The pitch is that instead of pouring more NAD boosters in, you plug the leak.
How it works: CD38 is an enzyme on the surface of cells, and one of the main users of NAD in the body. It gets more active with age.
Approval history: Found naturally in common foods, and sold over the counter as a supplement. Not an approved drug for any use, and no health claim about NAD, CD38 or ageing has been approved.
How FDA treats this kind of product
Approves prescription drugs, each for a named use. It also acts against unapproved products, including peptides sold online. Compounding pharmacies, which mix drugs to order, may make some compounds with a prescription. That only applies when the FDA puts the compound in a category of bulk ingredients it allows.
The legal category above is how The Longevity Archive reads U.S. Food and Drug Administration listings for Apigenin on the reviewed date. It is not a legal opinion. Rules change. Bringing a compound into the country, prescribing it and owning it can each be treated differently. Check with the agency before you act on anything here.
Apigenin in sport and the military
Whether Apigenin is banned in sport is set by the World Anti-Doping Code and by military rules, not by its legal status in the United States. Before you compete or get tested, look up Apigenin by name on the Prohibited List, or look up a named product in Global DRO. Under the World Anti-Doping Code, category S0 bans, at all times, any drug-like substance that meets two tests. No other section of the List covers it. And no government health regulator anywhere has a current approval for it as a treatment in people. Many substances that are approved somewhere are banned by name in another section. So approval does not mean a substance is allowed in sport.
- WADA Prohibited List
- Global DRO (check a named product)
- USADA (US athletes)
- Operation Supplement Safety (US service members)
The rules you compete or serve under decide this, not this page.
Apigenin in other countries
Frequently asked questions
Is Apigenin legal in the United States?
Apigenin can be sold in the United States as a supplement or cosmetic ingredient. Its legal category is "Sold as a supplement". That is not approval as a drug. FDA has not checked any health claim made for it. Versions you inject, and "research use only" versions, fall outside supplement rules, so that label does not make them legal to use in people. On the evidence, no completed trial in people is cited on its profile (1 human record with no result or no dose given). Note: Sold as a supplement, and found in ordinary foods including parsley, celery and chamomile. No approved health claim about NAD or ageing.
Can I buy Apigenin in the United States?
Yes, as a supplement or cosmetic. In the United States, Apigenin has the legal category "Sold as a supplement". So products you swallow, put on your skin or use as a cosmetic can be sold under supplement rules. Versions you inject, and products labeled "research use only", are not supplements. They are not approved for use in people. Note: Sold as a supplement, and found in ordinary foods including parsley, celery and chamomile. No approved health claim about NAD or ageing.
Is Apigenin FDA approved?
No. FDA status: Found naturally in common foods, and sold over the counter as a supplement. Not an approved drug for any use, and no health claim about NAD, CD38 or ageing has been approved.. Current US legal category: "Sold as a supplement". On the evidence, no completed trial in people is cited on its profile (1 human record with no result or no dose given).
Related compounds in the United States
Full research profile
How Apigenin works, the studies we cite, FDA status and the full legal summary are all on its compound profile.
Apigenin profileThis page is general information about the legal status of Apigenin in the United States, current as of Sep 2026. It is not legal advice. Legal status changes. For your own situation, check with U.S. Food and Drug Administration or ask a lawyer. Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use. Sellers named on the price pages are ranked by certificate tier, then price, and any affiliate income is disclosed there. Naming a seller is not a recommendation to buy or use anything.