Legal status by country
Is Caffeic acid phenethyl ester legal?
Written by Aaron CuhaReviewed Sep 2026
How Caffeic acid phenethyl ester is classified in the United States, United Kingdom, Australia and Canada, side by side. Each country has its own page with a direct answer, the regulator's approval status and what the classification means in practice.
All four countries, side by side
| Attribute | United States · FDA | United Kingdom · MHRA | Australia · TGA | Canada · Health Canada |
|---|---|---|---|---|
| Status | Not approved | Not approved | Not approved | Not approved |
| Classification | Sold as a dietary supplement | Sold as a supplement | Available as a supplement / complementary medicine | Sold as a supplement |
| Note | Mostly as a propolis constituent; purified CAPE is sold as a research chemical. | None recorded | None recorded | None recorded |
US FDA status: Not an approved drug. Sold as a supplement ingredient and as a constituent of propolis. No human clinical trial has been published. The lifespan signal is a Gehan-only reanalysis result in female mice.. Reviewed Sep 2026.
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General information current as of Sep 2026, not legal advice. Classifications change; confirm with the regulator or a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships.