Is Enalapril legal in the United Kingdom?

Did not extend mouse lifespan by the Interventions Testing Program's protocol test; a 2024 reanalysis found a 7 percent male median gain by the Gehan test, which weights early deaths. In people it is a blood pressure and heart failure drug with one of the deepest mortality records in cardiology, none of it about ageing.

Enalapril is an ACE inhibitor approved in the 1980s for hypertension and heart failure and still prescribed by the tens of millions as a generic. It is on this site because the NIA Interventions Testing Program tested it, and because the longevity community cites that test as a positive.

Mechanism: Enalapril is a prodrug hydrolysed in the liver to enalaprilat, which inhibits angiotensin-converting enzyme, lowering angiotensin II and aldosterone and raising bradykinin. In people this lowers blood pressure, reduces afterload, and in heart failure slows the progressive dilatation of the left ventricle, which is the mechanism the SOLVD investigators credited for the mortality benefit.

Regulatory history: FDA-approved (Vasotec, 1985) for hypertension and heart failure; generic enalapril maleate tablets and oral solution are marketed. The lifespan signal is a Gehan-only reanalysis result in male mice.

Licenses medicines for the UK market. A compound without a marketing authorisation is an unlicensed medicine, which can only lawfully be supplied for human use through a prescriber under the specials scheme, not sold as a research product.

The classification above is the The Longevity Archive reading of Medicines and Healthcare products Regulatory Agency listings for Enalapril at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.