Is Metreleptin legal?
Written by Aaron CuhaReviewed Sep 2026
- US: FDA-approved, prescription only
- UK: Licensed, prescription only (MHRA)
- AU: TGA-registered, prescription only
- CA: Health Canada approved, prescription only
The US comes first because most people ask about it. Each country has its own page. It names the agency, the law or rule, and what the legal category means in real life.
All four countries, side by side
| What we list | United States · FDA | United Kingdom · MHRA | Australia · TGA | Canada · Health Canada |
|---|---|---|---|---|
| Status | Approved | Approved | Approved | Approved |
| Legal category | FDA-approved, prescription only | Licensed, prescription only (MHRA) | TGA-registered, prescription only | Health Canada approved, prescription only |
| Note | Approved only for generalised lipodystrophy. Boxed warning for antibodies that block the drug and for T-cell lymphoma, a blood cancer. Only supplied through a restricted program. Clearly not approved for ordinary obesity. | None recorded | None recorded | None recorded |
| Agency | Check FDA directly | Check MHRA directly | Check TGA directly | Check Health Canada directly |
US FDA status: FDA-approved as Myalept for problems caused by too little leptin in generalised lipodystrophy, a rare condition where the body has almost no fat. It carries a boxed warning, the FDA's strongest, for two risks. The body can make antibodies that block the drug, and it can raise the risk of T-cell lymphoma, a blood cancer. It is only supplied through a restricted program. Not approved for obesity or partial lipodystrophy.. Reviewed Sep 2026.
Country by country
Is Metreleptin legal in the United States?
Yes. Metreleptin is an approved medicine in the United States. Its legal category is "FDA-approved, prescription only". The approval covers the use on its label. It is given out on prescription, not sold over the counter. Products labeled "research use only" are not covered by that approval, and that label does not make them legal to use in people. On the evidence, no completed trial in people is cited on its profile (1 human record with no result or no dose given).
The full United States answerIs Metreleptin legal in the United Kingdom?
Yes. Metreleptin is an approved medicine in the United Kingdom. Its legal category is "Licensed, prescription only (MHRA)". The approval covers the use on its label. It is given out on prescription, not sold over the counter. Products labeled "research use only" are not covered by that approval, and that label does not make them legal to use in people. On the evidence, no completed trial in people is cited on its profile (1 human record with no result or no dose given).
The full United Kingdom answerIs Metreleptin legal in Australia?
Yes. Metreleptin is an approved medicine in Australia. Its legal category is "TGA-registered, prescription only". The approval covers the use on its label. It is given out on prescription, not sold over the counter. Products labeled "research use only" are not covered by that approval, and that label does not make them legal to use in people. On the evidence, no completed trial in people is cited on its profile (1 human record with no result or no dose given).
The full Australia answerIs Metreleptin legal in Canada?
Yes. Metreleptin is an approved medicine in Canada. Its legal category is "Health Canada approved, prescription only". The approval covers the use on its label. It is given out on prescription, not sold over the counter. Products labeled "research use only" are not covered by that approval, and that label does not make them legal to use in people. On the evidence, no completed trial in people is cited on its profile (1 human record with no result or no dose given).
The full Canada answerMetreleptin in sport and the military
Whether Metreleptin is banned in sport is set by the World Anti-Doping Code and by military rules, not by its legal status. Before you compete or get tested, look up Metreleptin by name on the Prohibited List, or look up a named product in Global DRO. Under the World Anti-Doping Code, category S0 bans, at all times, any drug-like substance that meets two tests. No other section of the List covers it. And no government health regulator anywhere has a current approval for it as a treatment in people. Many substances that are approved somewhere are banned by name in another section. So approval does not mean a substance is allowed in sport.
- WADA Prohibited List
- Global DRO (check a named product)
- USADA (US athletes)
- Operation Supplement Safety (US service members)
The rules you compete or serve under decide this, not this page.
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General information, current as of Sep 2026. Not legal advice. Legal status changes. For your own situation, check with the agency or a lawyer. Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use. Sellers named on the price pages are ranked by certificate tier, then price, and any affiliate income is disclosed there. Naming a seller is not a recommendation to buy or use anything.