Legal status · Canada
Is MIB-626 legal in Canada?
Written by Aaron CuhaReviewed Sep 2026
Direct answer
No. MIB-626 is not approved for any medical use in Canada; its classification is "Investigational, not approved". Lawful access is limited to registered clinical trials. "Research use only" labeling on vials sold online does not make human use lawful. On the evidence, 4 human studies are cited on its profile.
MIB-626 in Canada at a glance
| Classification | Investigational, not approved |
|---|---|
| Note | Investigational. No Health Canada authorisation. |
| Health Canada approval status | Not approved by Health Canada; investigational |
| Human studies cited | 4 of 4 citations on the profile |
| Reviewed | Sep 2026 |
Classification and note come from the MIB-626 profile, checked against Health Canada, Health Products and Food Branch (Health Canada) listings at the reviewed date.
What this means
- 01
MIB-626 is being studied in registered clinical trials but has not received Health Canada marketing approval in Canada.
- 02
Lawful human access is limited to trial participation or a formal early-access scheme where one exists; there is no pharmacy product to prescribe.
- 03
Vials sold online "for research use only" are not trial material, and that label does not make human use lawful.
What MIB-626 is
The only NMN product with a real randomised trial programme: three placebo-controlled trials totalling about 104 participants, all of which measured blood NAD and safety. It raised blood NAD substantially every time. It did not change muscle strength, aerobic capacity, insulin sensitivity, liver fat, or any marker of kidney injury or inflammation in hospitalised patients.
MIB-626 is beta-nicotinamide mononucleotide. The molecule is the same one sold in supplement capsules.
Mechanism: The active molecule is beta-nicotinamide mononucleotide, which enters NAD synthesis one step below nicotinamide riboside: NMN is adenylylated by NMNAT enzymes directly to NAD, bypassing the NAMPT step that limits nicotinamide. The proprietary element is formulation rather than pharmacology, a defined microcrystalline polymorph intended to give reproducible, pharmaceutical-grade exposure, which is what allows dose-ranging and regulatory filing in a way a variable supplement powder does not.
Regulatory history: An investigational drug in the United States, developed under an IND by Metro International Biotech. It is not approved for any indication and is not the same regulatory object as NMN sold as a dietary supplement, although the molecule is identical. The existence of that IND is what triggered FDA's 2022 determination excluding NMN from the dietary supplement definition, a determination FDA reversed in September 2025.
How Health Canada treats this kind of product
Authorises drugs for sale through a Notice of Compliance and Drug Identification Number. A compound that is not authorised for sale cannot lawfully be sold for human use, and personal importation of prescription drugs is limited.
The classification above is the The Longevity Archive reading of Health Canada, Health Products and Food Branch listings for MIB-626 at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.
MIB-626 in other countries
Frequently asked questions
Is MIB-626 legal in Canada?
No. MIB-626 is not approved for any medical use in Canada; its classification is "Investigational, not approved". Lawful access is limited to registered clinical trials. "Research use only" labeling on vials sold online does not make human use lawful. On the evidence, 4 human studies are cited on its profile. Note: Investigational. No Health Canada authorisation.
Can I buy MIB-626 in Canada?
No approved product exists to buy. In Canada MIB-626 is classified as "Investigational, not approved", so there is no licensed pharmacy product. Vendors selling it "for research use only" are not selling it for human use, and that label does not change its legal status. This site does not list or recommend vendors. Note: Investigational. No Health Canada authorisation.
Is MIB-626 Health Canada approved?
No. In Canada MIB-626 is classified as "Investigational, not approved", which is not a Health Canada marketing approval. For comparison, the US FDA status is: An investigational drug in the United States, developed under an IND by Metro International Biotech. It is not approved for any indication and is not the same regulatory object as NMN sold as a dietary supplement, although the molecule is identical. The existence of that IND is what triggered FDA's 2022 determination excluding NMN from the dietary supplement definition, a determination FDA reversed in September 2025.. On the evidence, 4 human studies are cited on its profile.
Related compounds in Canada
Full research profile
Mechanism, cited studies, FDA status and the full legal summary for MIB-626 live on its compound profile.
MIB-626 profileThis page is general information about the regulatory status of MIB-626 in Canada, current as of Sep 2026. It is not legal advice, and classifications change; check Health Canada, Health Products and Food Branch directly or consult a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships and does not recommend where to buy anything.