Legal status · Canada
Is NNC0165-1875 legal in Canada?
Written by Aaron CuhaReviewed Sep 2026
Direct answer
No. NNC0165-1875 is not approved for any medical use in Canada; its classification is "Investigational, not approved". Lawful access is limited to registered clinical trials. "Research use only" labeling on vials sold online does not make human use lawful. On the evidence, 3 human studies are cited on its profile.
NNC0165-1875 in Canada at a glance
| Classification | Investigational, not approved |
|---|---|
| Health Canada approval status | Not approved by Health Canada; investigational |
| Human studies cited | 3 of 3 citations on the profile |
| Reviewed | Sep 2026 |
Classification and note come from the NNC0165-1875 profile, checked against Health Canada, Health Products and Food Branch (Health Canada) listings at the reviewed date.
What this means
- 01
NNC0165-1875 is being studied in registered clinical trials but has not received Health Canada marketing approval in Canada.
- 02
Lawful human access is limited to trial participation or a formal early-access scheme where one exists; there is no pharmacy product to prescribe.
- 03
Vials sold online "for research use only" are not trial material, and that label does not make human use lawful.
What NNC0165-1875 is
The clearest test of stacking a second appetite hormone onto semaglutide, and it failed on both counts. The authors call the added effect modest and not clinically meaningful, and the higher dose was not tolerated.
Peptide YY is the gut hormone that tells your brain the meal is over, acting through a different receptor from GLP-1. On paper it is the obvious partner: two independent satiety pathways should add up.
Mechanism: A long-acting analogue of PYY(3-36), the truncated form of peptide YY released from L cells in the distal gut after eating. PYY(3-36) is selective for the Y2 receptor, which is presynaptic and inhibitory on hypothalamic neuropeptide Y neurons, reducing the orexigenic drive.
Regulatory history: Investigational. Not approved. Phase 2 completed with a result its own authors describe as not clinically meaningful.
How Health Canada treats this kind of product
Authorises drugs for sale through a Notice of Compliance and Drug Identification Number. A compound that is not authorised for sale cannot lawfully be sold for human use, and personal importation of prescription drugs is limited.
The classification above is the The Longevity Archive reading of Health Canada, Health Products and Food Branch listings for NNC0165-1875 at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.
NNC0165-1875 in other countries
Frequently asked questions
Is NNC0165-1875 legal in Canada?
No. NNC0165-1875 is not approved for any medical use in Canada; its classification is "Investigational, not approved". Lawful access is limited to registered clinical trials. "Research use only" labeling on vials sold online does not make human use lawful. On the evidence, 3 human studies are cited on its profile.
Can I buy NNC0165-1875 in Canada?
No approved product exists to buy. In Canada NNC0165-1875 is classified as "Investigational, not approved", so there is no licensed pharmacy product. Vendors selling it "for research use only" are not selling it for human use, and that label does not change its legal status. This site does not list or recommend vendors.
Is NNC0165-1875 Health Canada approved?
No. In Canada NNC0165-1875 is classified as "Investigational, not approved", which is not a Health Canada marketing approval. For comparison, the US FDA status is: Investigational. Not approved. Phase 2 completed with a result its own authors describe as not clinically meaningful.. On the evidence, 3 human studies are cited on its profile.
Related compounds in Canada
Full research profile
Mechanism, cited studies, FDA status and the full legal summary for NNC0165-1875 live on its compound profile.
NNC0165-1875 profileThis page is general information about the regulatory status of NNC0165-1875 in Canada, current as of Sep 2026. It is not legal advice, and classifications change; check Health Canada, Health Products and Food Branch directly or consult a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships and does not recommend where to buy anything.