Legal status · Canada
Is NNC0480-0389 legal in Canada?
Written by Aaron CuhaReviewed Sep 2026
Direct answer
No. NNC0480-0389 is not approved for any medical use in Canada; its classification is "Investigational, not approved". Lawful access is limited to registered clinical trials. "Research use only" labeling on vials sold online does not make human use lawful. On the evidence, 3 human studies are cited on its profile.
NNC0480-0389 in Canada at a glance
| Classification | Investigational, not approved |
|---|---|
| Health Canada approval status | Not approved by Health Canada; investigational |
| Human studies cited | 3 of 3 citations on the profile |
| Reviewed | Sep 2026 |
Classification and note come from the NNC0480-0389 profile, checked against Health Canada, Health Products and Food Branch (Health Canada) listings at the reviewed date.
What this means
- 01
NNC0480-0389 is being studied in registered clinical trials but has not received Health Canada marketing approval in Canada.
- 02
Lawful human access is limited to trial participation or a formal early-access scheme where one exists; there is no pharmacy product to prescribe.
- 03
Vials sold online "for research use only" are not trial material, and that label does not make human use lawful.
What NNC0480-0389 is
A GIP receptor agonist being added to semaglutide in phase 2, with 500 participants. Its mirror image, a GIP antagonist added to semaglutide, is in phase 2 at the same time.
This is the agonist half of the GIP paradox, tested as an add-on rather than as a single molecule. Novo Nordisk makes semaglutide, so pairing it with a separate long-acting GIP receptor agonist is a route to a tirzepatide-like dual mechanism using two drugs instead of one.
Mechanism: A long-acting agonist at the GIP receptor, a class B1 G protein-coupled receptor that raises cyclic AMP. In the pancreatic beta cell that potentiates glucose-stimulated insulin secretion in a glucose-dependent way.
Regulatory history: Investigational. Not approved anywhere. Phase 2 dose finding completed with no published results.
How Health Canada treats this kind of product
Authorises drugs for sale through a Notice of Compliance and Drug Identification Number. A compound that is not authorised for sale cannot lawfully be sold for human use, and personal importation of prescription drugs is limited.
The classification above is the The Longevity Archive reading of Health Canada, Health Products and Food Branch listings for NNC0480-0389 at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.
NNC0480-0389 in other countries
Frequently asked questions
Is NNC0480-0389 legal in Canada?
No. NNC0480-0389 is not approved for any medical use in Canada; its classification is "Investigational, not approved". Lawful access is limited to registered clinical trials. "Research use only" labeling on vials sold online does not make human use lawful. On the evidence, 3 human studies are cited on its profile.
Can I buy NNC0480-0389 in Canada?
No approved product exists to buy. In Canada NNC0480-0389 is classified as "Investigational, not approved", so there is no licensed pharmacy product. Vendors selling it "for research use only" are not selling it for human use, and that label does not change its legal status. This site does not list or recommend vendors.
Is NNC0480-0389 Health Canada approved?
No. In Canada NNC0480-0389 is classified as "Investigational, not approved", which is not a Health Canada marketing approval. For comparison, the US FDA status is: Investigational. Not approved anywhere. Phase 2 dose finding completed with no published results.. On the evidence, 3 human studies are cited on its profile.
Related compounds in Canada
Full research profile
Mechanism, cited studies, FDA status and the full legal summary for NNC0480-0389 live on its compound profile.
NNC0480-0389 profileThis page is general information about the regulatory status of NNC0480-0389 in Canada, current as of Sep 2026. It is not legal advice, and classifications change; check Health Canada, Health Products and Food Branch directly or consult a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships and does not recommend where to buy anything.