Semax vs Bromantane
Written by Aaron CuhaReviewed Sep 2026
The short answer
A peptide and a small molecule from the same research tradition, sold for overlapping uses. The clinical studies for both are in Russian, small, and mostly come from single research groups.
- Semax people
- 354
- Semax nulls
- 0
- Bromantane people
- 728
- Bromantane nulls
- 1
Dose
No human dose established
Amounts that circulate in forums and on vendor pages are not a human dose. Amounts that were given in studies sit in Human evidence on this page.
Commonly reported injected amounts, in mcg. The Russian approved product is an intranasal solution, so it gives no injectable amount.
Amounts commonly reported for injected Semax, recorded for this archive's reconstitution calculator, are 200, 300 and 600 mcg. They are self-reports rather than trial doses, and this archive does not recommend any of them. No US approval sets a dose for injected Semax, and Semax is approved in Russia and Ukraine, where its label carries one. These reported amounts are not that label's dose.
| Reported amount | Where the number comes from |
|---|---|
| 200 mcg | Commonly reported, no published human dosing trial |
| 300 mcg | Commonly reported, no published human dosing trial |
| 600 mcg | Commonly reported, no published human dosing trial |
Dose
No human dose established
Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose.
3 completed trials, 728 people given it
First-hand reports are counted on each profile and never added together. This page sets two published records side by side. It does not pick a winner.
Column A
SemaxSemax (synthetic ACTH 4-10 analogue)
A lab-made peptide nose spray approved in Russia for stroke and memory problems. It is studied for raising BDNF, a protein that helps brain cells grow.
Column B
BromantaneN-(2-adamantyl)-N-(para-bromophenyl)amine
Bromantane is a Russian drug sold in the West as a focus pill. It does have human studies that compared it with a dummy pill. But every one of them scored tiredness and anxiety in people with long-term exhaustion, not thinking. Almost all of the work is small, in Russian, and from one Moscow research group. Tested athletes are banned from using it in competition under the 2026 World Anti-Doping Agency (WADA) list.
Side by side, on the facts we can check
| What we compare | Semax | Bromantane |
|---|---|---|
| Category | Nootropic & CNS | Nootropic & CNS |
| FDA status | Not FDA-approved (approved in Russia and Ukraine). In July 2026 the FDA's Pharmacy Compounding Advisory Committee voted in favor of letting pharmacies make it. The FDA has not written the rule yet | Not approved by the FDA for any use, and no FDA label exists. It is registered and sold in Russia under the name Ladasten, for asthenia, a condition of lasting weakness and tiredness. In the United States and elsewhere it is sold as a research chemical or as an unapproved brain-boosting supplement. |
| Half-life | Short (minutes); intranasal use | No published human pharmacokinetic study was located in this pass. Claims of a long duration of action circulate widely and none of them traces to a measured human plasma curve. |
| Molecular weight | 813.9 Da | 306.2 Da (C16H20BrN). An adamantane derivative, not a peptide. |
| How it works | It raises BDNF and NGF, two proteins that help brain cells grow and connect. It also works on the brain's melanocortin and dopamine systems. The idea is that this protects brain cells and helps them adapt. | Shown in rats, only guessed at in people. Bromantane is not a peptide. It is built on adamantane, a small cage-shaped molecule. Russian doctors class it as an 'actoprotector', a drug meant to help you cope with strain, not as a stimulant. In rats, one dose by mouth changed how much dopamine, the brain's drive and reward chemical, several brain areas were set up to make. In slices of rat brain, it made a short boost in the links between nerve cells last much longer. Blocking protein building, or blocking two dopamine receptors, stopped or weakened that. The idea that it raises your ability to make dopamine, instead of forcing it out the way amphetamine does, rests only on that rat work. Nobody has measured dopamine in a person taking bromantane. |
| Studies in people | 4 | 3 |
| Evidence | Moderate: 4 completed trials, 354 people given it | Moderate: 3 completed trials, 728 people given it |
| Legal status, US | Not approved; research use only | Not approved; research use only |
Frequently asked questions
What is the difference between Semax and Bromantane?
Semax: A lab-made peptide nose spray approved in Russia for stroke and memory problems. It is studied for raising BDNF, a protein that helps brain cells grow. Bromantane: Bromantane is a Russian drug sold in the West as a focus pill. It does have human studies that compared it with a dummy pill. But every one of them scored tiredness and anxiety in people with long-term exhaustion, not thinking. Almost all of the work is small, in Russian, and from one Moscow research group. Tested athletes are banned from using it in competition under the 2026 World Anti-Doping Agency (WADA) list.
Which has stronger research evidence, Semax or Bromantane?
Each compound gets a band worked out from facts we counted, with the math shown. Semax is Moderate (4 completed trials, 354 people given it). Bromantane is Moderate (3 completed trials, 728 people given it). That counts how much has been done in people. It does not rate whether either one works, and neither one is called the winner.
Are Semax and Bromantane FDA-approved?
Semax: Not FDA-approved (approved in Russia and Ukraine). In July 2026 the FDA's Pharmacy Compounding Advisory Committee voted in favor of letting pharmacies make it. The FDA has not written the rule yet. Bromantane: Not approved by the FDA for any use, and no FDA label exists. It is registered and sold in Russia under the name Ladasten, for asthenia, a condition of lasting weakness and tiredness. In the United States and elsewhere it is sold as a research chemical or as an unapproved brain-boosting supplement..
Related posts
Blog articles that cover Semax or Bromantane, newest first.
- Research / Sep 27, 2026 / 9 minPeptides for Sleep: DSIP, Epitalon and Pinealon Against the Evidence
- Safety / Sep 27, 2026 / 9 minPeptide Side Effects by Class: What Is Documented, What Is Anecdotal
- Regulation / Sep 27, 2026 / 9 minFDA Peptide Status in 2026: The Category 2 Removals, the July Votes, and What Actually Changed
Reviewed Sep 2026. This page puts two published records side by side. It is for learning, and it is not medical advice. When this site shows a dose, it is the dose a trial or a clinic actually used, or what people say they did, with the source attached. None of it tells you what to take.