Sermorelin / GHRP vs CJC-1295 / Ipamorelin
Written by Aaron CuhaReviewed Sep 2026
The short answer
The two standard growth hormone blends. One has something the other does not. A GHRH paired with a GHRP has real short term human data: adding a GHRH to GHRP-6 roughly doubled the growth hormone peak in 20 patients. That was a single diagnostic test given into a vein, not a nightly routine, and neither specific vial has ever been studied.
- Sermorelin / GHRP people
- 56
- Sermorelin / GHRP nulls
- 1
- CJC-1295 / Ipamorelin people
- 20
- CJC-1295 / Ipamorelin nulls
- 0
Dose
No human dose established
Amounts that circulate in forums and on vendor pages are not a human dose. Amounts that were given in studies sit in Human evidence on this page.
Amounts for the sermorelin in the blend, in mcg, commonly reported. The GHRP moves with it in the label ratio.
Amounts commonly reported for the sermorelin in this blend, recorded for this archive's reconstitution calculator, are 100, 200 and 300 mcg. They are self-reports rather than trial doses, and this archive does not recommend any of them. No human dose has been established for Sermorelin / GHRP.
| Reported amount | Where the number comes from |
|---|---|
| 100 mcg | Commonly reported, no published human dosing trial |
| 200 mcg | Commonly reported, no published human dosing trial |
| 300 mcg | Commonly reported, no published human dosing trial |
Dose
No human dose established for this blend
No published study has tested CJC-1295 with ipamorelin together. Each component has its own profile. Commonly reported chips track the CJC-1295 half of the vial and are not a human dose.
Amounts for the CJC-1295 in the blend, in mcg, commonly reported. The ipamorelin moves with it in the label ratio.
Amounts commonly reported for the CJC-1295 in this blend, recorded for this archive's reconstitution calculator, are 100, 200 and 300 mcg. They are self-reports rather than trial doses, and this archive does not recommend any of them. No human dose has been established for CJC-1295 / Ipamorelin.
| Reported amount | Where the number comes from |
|---|---|
| 100 mcg | Commonly reported, no published human dosing trial |
| 200 mcg | Commonly reported, no published human dosing trial |
| 300 mcg | Commonly reported, no published human dosing trial |
First-hand reports are counted on each profile and never added together. This page sets two published records side by side. It does not pick a winner.
Column A
Sermorelin / GHRPSermorelin combined with GHRP-2 or GHRP-6 (compounding pharmacy growth hormone blend)
The standard growth hormone blend from compounding pharmacies, usually 5 mg sermorelin with 5 mg GHRP-2 in one 10 mg vial. It is the only blend on this site where this kind of pairing has real human data. In 20 patients, adding GHRH to GHRP-6 roughly doubled the growth hormone peak, 54.7 against 25.7 micrograms per litre. But that was one dose into a vein, as a hospital test, not a nightly shot under the skin. The vial itself has never been studied.
Column B
CJC-1295 / IpamorelinCJC-1295 and Ipamorelin blend (GHRH analogue plus ghrelin mimetic)
The most popular peptide pair on the market. It is sold as 5 mg plus 5 mg, or 10 mg plus 10 mg, in one vial, so each peptide is half the powder by weight. No published study has tested CJC-1295 with ipamorelin in people or in animals. And the two peptides clear from the body at speeds roughly a hundredfold apart, so no single shot schedule is right for both.
Side by side, on the facts we can check
| What we compare | Sermorelin / GHRP | CJC-1295 / Ipamorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| FDA status | Not approved as a blend. Sermorelin was once FDA-approved as Geref, and now comes from mixing (compounding) pharmacies. GHRP-2 is approved in Japan only for use in a diagnostic test. GHRP-6 is not approved anywhere. | Not approved. Neither part is an approved drug, and the mix has never been sent to a regulator or studied. |
| Half-life | Not one number. Both components clear within roughly an hour, the secretagogue somewhat more slowly than the GHRH fragment, and neither has been measured in the presence of the other. | Not one number. The two components clear on completely different timescales, one within a few hours and the other over about a week. |
| Molecular weight | Mixture; sermorelin 3,357.9 Da, GHRP-2 817.0 Da, GHRP-6 873.0 Da | Mixture; CJC-1295 with DAC about 3,647.2 Da, ipamorelin 711.85 Da |
| How it works | Sermorelin presses the GHRH switch in the pituitary. That makes each growth hormone burst bigger, while the brain's feedback checks stay in place. GHRP-2 and GHRP-6 press a different switch, GHS-R1a, the ghrelin receptor, first found in 1996. That releases growth hormone and also eases off somatostatin, the body's brake on growth hormone. Because the switches are different, and easing the brake boosts the GHRH signal, the pair gives a bigger burst than either alone. In human tests it was roughly double. GHRP-6 in particular also raises appetite, cortisol (a stress hormone) and prolactin. That is why later, more targeted peptides were developed. | Two switches on the same pituitary cell. CJC-1295 presses the GHRH switch, which makes each growth hormone burst bigger. In the DAC version, a hook that grabs albumin, a blood protein, stretches that signal out for days. Ipamorelin presses the ghrelin switch, called GHS-R1a. That releases growth hormone and also eases off somatostatin, the body's brake on growth hormone. In human tests, pressing both kinds of switch gave a bigger burst than either alone. But those tests used the body's own GHRH with GHRP-6, not this pair. |
| Studies in people | 5 | 3 |
| Evidence | Limited: 4 completed trials, 56 people given it | Limited: 2 completed trials, 20 people given it |
| Legal status, US | No approved blend; sermorelin is available compounded | Not approved; research use only |
Frequently asked questions
What is the difference between Sermorelin / GHRP and CJC-1295 / Ipamorelin?
Sermorelin / GHRP: The standard growth hormone blend from compounding pharmacies, usually 5 mg sermorelin with 5 mg GHRP-2 in one 10 mg vial. It is the only blend on this site where this kind of pairing has real human data. In 20 patients, adding GHRH to GHRP-6 roughly doubled the growth hormone peak, 54.7 against 25.7 micrograms per litre. But that was one dose into a vein, as a hospital test, not a nightly shot under the skin. The vial itself has never been studied. CJC-1295 / Ipamorelin: The most popular peptide pair on the market. It is sold as 5 mg plus 5 mg, or 10 mg plus 10 mg, in one vial, so each peptide is half the powder by weight. No published study has tested CJC-1295 with ipamorelin in people or in animals. And the two peptides clear from the body at speeds roughly a hundredfold apart, so no single shot schedule is right for both.
Which has stronger research evidence, Sermorelin / GHRP or CJC-1295 / Ipamorelin?
Each compound gets a band worked out from facts we counted, with the math shown. Sermorelin / GHRP is Limited (4 completed trials, 56 people given it). CJC-1295 / Ipamorelin is Limited (2 completed trials, 20 people given it). That counts how much has been done in people. It does not rate whether either one works, and neither one is called the winner.
Are Sermorelin / GHRP and CJC-1295 / Ipamorelin FDA-approved?
Sermorelin / GHRP: Not approved as a blend. Sermorelin was once FDA-approved as Geref, and now comes from mixing (compounding) pharmacies. GHRP-2 is approved in Japan only for use in a diagnostic test. GHRP-6 is not approved anywhere.. CJC-1295 / Ipamorelin: Not approved. Neither part is an approved drug, and the mix has never been sent to a regulator or studied..
Reviewed Sep 2026. This page puts two published records side by side. It is for learning, and it is not medical advice. When this site shows a dose, it is the dose a trial or a clinic actually used, or what people say they did, with the source attached. None of it tells you what to take.