Is Clusterin legal in the United States?

A blood protein that goes up with exercise. In old mice and in mice with an Alzheimer-like illness, it calmed brain inflammation. It is higher in people who exercise. The only trials in people that changed it on purpose pushed it down, for cancer, and one stopped early.

Nobody has been given clusterin as a treatment. The record in people runs the opposite way to the exercise idea, and should never be quoted as supporting it.

How it works: In mice, clusterin injected into a vein sticks to the cells lining blood vessels in the brain and quietens inflammation genes there, both in a fast brain inflammation model and in an Alzheimer model. In the same paper, exercising animals show a coordinated rise in a set of brakes on the complement system, part of the immune system.

Approval history: Clusterin has never been given to a person as a treatment, and it is not approved anywhere. The only drug aimed at clusterin to reach human studies is custirsen. It lowers clusterin, was developed for cancer, and is not approved.

Approves prescription drugs, each for a named use. It also acts against unapproved products, including peptides sold online. Compounding pharmacies, which mix drugs to order, may make some compounds with a prescription. That only applies when the FDA puts the compound in a category of bulk ingredients it allows.

The legal category above is how The Longevity Archive reads U.S. Food and Drug Administration listings for Clusterin on the reviewed date. It is not a legal opinion. Rules change. Bringing a compound into the country, prescribing it and owning it can each be treated differently. Check with the agency before you act on anything here.

Check FDA directly

Whether Clusterin is banned in sport is set by the World Anti-Doping Code and by military rules, not by its legal status in the United States. Before you compete or get tested, look up Clusterin by name on the Prohibited List, or look up a named product in Global DRO. Under the World Anti-Doping Code, category S0 bans, at all times, any drug-like substance that meets two tests. No other section of the List covers it. And no government health regulator anywhere has a current approval for it as a treatment in people. Many substances that are approved somewhere are banned by name in another section. So approval does not mean a substance is allowed in sport.

• WADA Prohibited List
• Global DRO (check a named product)
• USADA (US athletes)
• Operation Supplement Safety (US service members)

The rules you compete or serve under decide this, not this page.