Is E5 Plasma Fraction legal in Canada?

A purified fraction of plasma from young pigs, given to old rats, which more than halved epigenetic age in blood, heart and liver. No human has received it.

E5 is a purified fraction of plasma taken from young adult pigs. The single study behind it, published in GeroScience in 2024, first developed and validated six epigenetic clocks for rat tissues using 613 tissue samples, including two clocks that work across both human and rat tissues, then used those clocks to measure what the porcine plasma fraction did to old rats.

Mechanism: Not established, in any species. The paper measures outcomes, chiefly epigenetic clock readings and organ function markers, rather than identifying which component of the fraction acts on what.

Regulatory history: Not approved anywhere. No registered human trial of a porcine plasma fraction for an ageing indication exists on ClinicalTrials.gov. This is a research preparation.

Authorises drugs for sale through a Notice of Compliance and Drug Identification Number. A compound that is not authorised for sale cannot lawfully be sold for human use, and personal importation of prescription drugs is limited.

The classification above is the The Longevity Archive reading of Health Canada, Health Products and Food Branch listings for E5 Plasma Fraction at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.