Legal status by country
Is Metformin plus rapamycin legal?
Written by Aaron CuhaReviewed Sep 2026
How Metformin plus rapamycin is classified in the United States, United Kingdom, Australia and Canada, side by side. Each country has its own page with a direct answer, the regulator's approval status and what the classification means in practice.
All four countries, side by side
| Attribute | United States · FDA | United Kingdom · MHRA | Australia · TGA | Canada · Health Canada |
|---|---|---|---|---|
| Status | Approved | Approved | Approved | Approved |
| Classification | FDA-approved, prescription only | Licensed, prescription only (MHRA) | TGA-registered, prescription only | Health Canada approved, prescription only |
| Note | Each drug separately; the combination for ageing is off-label. | Each drug separately; combination off-label. | Each drug separately; combination off-label. | Each drug separately; combination off-label. |
US FDA status: Both drugs are FDA-approved for other indications (metformin for type 2 diabetes, rapamycin as sirolimus for transplant rejection and other uses). The combination is not approved for anything. The lifespan result is in mice and lacks a contemporaneous rapamycin-alone comparison.. Reviewed Sep 2026.
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General information current as of Sep 2026, not legal advice. Classifications change; confirm with the regulator or a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships.