CJC-1295 vs Modified GRF 1-29
Written by Aaron CuhaReviewed Sep 2026
The short answer
These are sold as two versions of one product, with and without DAC. They are not two versions of one product, and the trial data everyone quotes belongs to only one of them.
- CJC-1295 people
- 0
- CJC-1295 nulls
- 1
- Modified GRF 1-29 people
- 0
- Modified GRF 1-29 nulls
- 0
Dose
No human dose established
Amounts that circulate in forums and on vendor pages are not a human dose. Amounts that were given in studies sit in Human evidence on this page.
Commonly reported amounts for the no-DAC form, in mcg. The DAC form is usually reported in mg per week: enter that and switch the unit to mg.
Amounts commonly reported for the no-DAC form of CJC-1295, recorded for this archive's reconstitution calculator, are 100, 200 and 300 mcg. They are self-reports rather than trial doses, and this archive does not recommend any of them. No human dose has been established for CJC-1295.
| Reported amount | Where the number comes from |
|---|---|
| 100 mcg | Commonly reported, no published human dosing trial |
| 200 mcg | Commonly reported, no published human dosing trial |
| 300 mcg | Commonly reported, no published human dosing trial |
Dose
No human dose established
Amounts that were given in studies sit in Human evidence on this page. None of them is a personal dose.
1 completed trial, 0 people given it
First-hand reports are counted on each profile and never added together. This page sets two published records side by side. It does not pick a winner.
Column A
CJC-1295CJC-1295 (GHRH analogue)
A lab-made copy of the body's growth hormone releasing signal, built to last longer. It keeps growth hormone and IGF-1 raised for days.
Column B
Modified GRF 1-29Modified GRF 1-29, tetrasubstituted human growth hormone releasing factor 1-29
Sold as "CJC-1295 without DAC", which makes no sense. The DAC is the part that makes a molecule CJC-1295. The human study everyone quotes found growth hormone 2 to 10 fold higher for 6 days or more, with half a dose cleared in 5.8 to 8.1 days. That study used the DAC form. No human study of the version without DAC has been found.
The mistake this page exists to correct
Modified GRF 1-29 is routinely labelled CJC-1295 without DAC, and that makes no sense. DAC is the add on that makes a molecule CJC-1295 in the first place. The human result quoted for both, growth hormone raised two to ten fold for six days or more with a half life of 5.8 to 8.1 days, came from the DAC form. No human trial of the version without DAC has been found. A half life measured in days and one measured in minutes do not fit the same dosing schedule, and they are not the same molecule.
Side by side, on the facts we can check
| What we compare | CJC-1295 | Modified GRF 1-29 |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| FDA status | Not FDA-approved | Not approved for any use, and not reviewed. Sermorelin, the unchanged form of GRF 1-29, was an approved medicine in the United States. It is no longer sold in its original form. Tesamorelin, a different copy of the brain's growth hormone release signal (GHRH), is approved for the shifted body fat some people with HIV get. |
| Half-life | ~6-8 days (DAC version) | Not measured in humans for this compound. For scale, native GRF 1-29 is cleared within minutes, while the albumin-bound DAC version was measured at about 6 days in healthy adults. |
| Molecular weight | 3,647.2 Da | About 3,368 Da for the tetrasubstituted 29 amino acid peptide without the DAC maleimide. |
| How it works | It switches on the GHRH receptor on the pituitary gland, which makes the gland release more growth hormone. The DAC version sticks to albumin in the blood, so it keeps working longer. | It copies growth hormone releasing hormone (GHRH). It presses the GHRH switch in the pituitary, the small gland under the brain. That tells the gland to release growth hormone, which then raises IGF-1, a growth signal made mostly in the liver. The four amino acid swaps protect it from DPP-4, the enzyme that breaks down the natural hormone. So it lasts somewhat longer in the blood than a few minutes. It does not stick to albumin. Growth hormone still comes out in bursts. How much comes out depends on your own pituitary, and on somatostatin, the body's brake on growth hormone. That is the real-life difference between a peptide that nudges your gland and a shot of growth hormone itself. |
| Studies in people | 4 | 2 |
| Evidence | Limited: 2 completed trials, none stating how many people | Limited: 1 completed trial, none stating how many people |
| Legal status, US | Not approved; research use only | Not approved; research use only |
Frequently asked questions
What is the difference between CJC-1295 and Modified GRF 1-29?
CJC-1295: A lab-made copy of the body's growth hormone releasing signal, built to last longer. It keeps growth hormone and IGF-1 raised for days. Modified GRF 1-29: Sold as "CJC-1295 without DAC", which makes no sense. The DAC is the part that makes a molecule CJC-1295. The human study everyone quotes found growth hormone 2 to 10 fold higher for 6 days or more, with half a dose cleared in 5.8 to 8.1 days. That study used the DAC form. No human study of the version without DAC has been found.
Which has stronger research evidence, CJC-1295 or Modified GRF 1-29?
Each compound gets a band worked out from facts we counted, with the math shown. CJC-1295 is Limited (2 completed trials, none stating how many people). Modified GRF 1-29 is Limited (1 completed trial, none stating how many people). That counts how much has been done in people. It does not rate whether either one works, and neither one is called the winner.
Are CJC-1295 and Modified GRF 1-29 FDA-approved?
CJC-1295: Not FDA-approved. Modified GRF 1-29: Not approved for any use, and not reviewed. Sermorelin, the unchanged form of GRF 1-29, was an approved medicine in the United States. It is no longer sold in its original form. Tesamorelin, a different copy of the brain's growth hormone release signal (GHRH), is approved for the shifted body fat some people with HIV get..
Related posts
Blog articles that cover CJC-1295 or Modified GRF 1-29, newest first.
Reviewed Sep 2026. This page puts two published records side by side. It is for learning, and it is not medical advice. When this site shows a dose, it is the dose a trial or a clinic actually used, or what people say they did, with the source attached. None of it tells you what to take.